دورية أكاديمية
Modeling the effect of the cephalic phase of insulin secretion on glucose metabolism
| العنوان: | Modeling the effect of the cephalic phase of insulin secretion on glucose metabolism |
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| المؤلفون: | Guemes, A, Herrero, P, Bondia, J, Georgiou, P |
| المصدر: | 1186 ; 1173 |
| بيانات النشر: | Springer Verlag |
| سنة النشر: | 2019 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Technology, Life Sciences & Biomedicine, Computer Science, Interdisciplinary Applications, Engineering, Biomedical, Mathematical & Computational Biology, Medical Informatics, Cephalic phase, Neural modeling, Insulin secretion, Vagus nerve, Metabolic modeling, BETA-CELL FUNCTION, VAGAL-STIMULATION, NERVE-STIMULATION, ELECTRICAL-STIMULATION, NEURAL REGULATION, HEPATIC GLUCOSE, MINIMAL MODEL, HEART-RATE, C-PEPTIDE, GLUCAGON, Acetylcholine, Blood Glucose, Glucose, Humans, Insulin, Insulin Resistance |
| الوصف: | The nervous system has a significant impact in glucose homeostasis and endocrine pancreatic secretion in humans, especially during the cephalic phase of insulin release (CPIR); that is, before a meal is absorbed. However, the underlying mechanisms of this neural-pancreatic interaction are not well understood and therefore often neglected, despite their significance to achieving an optimal glucose control. As a result, the dynamics of insulin release from the pancreas are currently described by mathematical models that reproduce the behavior of the β cells using exclusively glucose levels and other hormones as inputs. To bridge this gap, we have combined, for the first time, metabolic and neural mathematical models in a unified system to reproduce to a great extent the ideal glucoregulation observed in healthy subjects. Our results satisfactorily replicate the CPIR and its impact during the post-absorptive phase. Furthermore, the proposed model gives insight into the physiological interaction between the brain and the pancreas in healthy people and suggests the potential of considering the neural information for restoring glucose control in people with diabetes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0140-0118 |
| العلاقة: | Medical and Biological Engineering and Computing; http://hdl.handle.net/10044/1/77906Test |
| DOI: | 10.1007/s11517-019-01950-x |
| الإتاحة: | https://doi.org/10.1007/s11517-019-01950-xTest http://hdl.handle.net/10044/1/77906Test |
| حقوق: | © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| رقم الانضمام: | edsbas.D0D53C65 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 01400118 |
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| DOI: | 10.1007/s11517-019-01950-x |