دورية أكاديمية
A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response
| العنوان: | A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response |
|---|---|
| المؤلفون: | Macare, C, Ducci, F, Zhang, Y, Ruggeri, B, Jia, T, Kaakinen, M, Kalsi, G, Charoen, P, Casoni, F, Peters, J, Bromberg, U, Hil, M, Buxton, J, Blakemore, A, Veijola, J, Buchel, C, Banaschewski, T, Bokde, ALW, Conrod, P, Flor, H, Frouin, V, Gallinat, J, Garavan, H, Gowland, PA, Heinz, A, Itternnann, B, Lathrop, M, Martinot, J-L, Paus, T, Desrivieres, S, Munafo, M, Jarvelin, M-R, Schumanna, G |
| المصدر: | 1114 ; 1103 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2018 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Pharmacology & Pharmacy, Psychiatry, Neurosciences & Neurology, fMRI, Genetics, IMAGEN-ALSPAC-NFBC, Meta-analysis, Risk taking, Smoking, NICOTINE DEPENDENCE, SERUM COTININE, CIGARETTE-SMOKING, BIRTH COHORT, HUMAN BRAIN, ASSOCIATION, DOPAMINE, VULNERABILITY, ADDICTION, ANKK1, Adolescent, Adolescent Behavior, Anticipation, Psychological, Behavior, Addictive, Brain |
| الوصف: | The TTC12-ANKK1-DRD2 gene-cluster has been implicated in adult smoking. Here, we investigated the contribution of individual genes in the TTC12-ANKK1-DRD2 cluster in smoking and their association with smoking-associated reward processing in adolescence. A meta-analysis of TTC12-ANKK1-DRD2 variants and self-reported smoking behaviours was performed in four European adolescent cohorts (N = 14,084). The minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking (p = 5.0 × 10−4) and higher plasma cotinine levels (p = 7.0 × 10−5). This risk allele was linked to an increased ventral-striatal blood-oxygen level-dependent (BOLD) response during reward anticipation (n = 1,263) and with higher DRD2 gene expression in the striatum (p = 0.013), but not with TTC12 or ANKK gene expression. These data suggest a role for the TTC12-ANKK1-DRD2 gene-cluster in adolescent smoking behaviours, provide evidence for the involvement of DRD2 in the early stages of addiction and support the notion that genetically-driven inter-individual differences in dopaminergic transmission mediate reward sensitivity and risk to smoking. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0924-977X |
| العلاقة: | European Neuropsychopharmacology; http://hdl.handle.net/10044/1/85449Test |
| DOI: | 10.1016/j.euroneuro.2018.07.101 |
| الإتاحة: | https://doi.org/10.1016/j.euroneuro.2018.07.101Test http://hdl.handle.net/10044/1/85449Test |
| حقوق: | ©2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0Test/ ) ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.48728F9 |
| قاعدة البيانات: | BASE |
| تدمد: | 0924977X |
|---|---|
| DOI: | 10.1016/j.euroneuro.2018.07.101 |