دورية أكاديمية
Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age ; ENEngelskEnglishFunctional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age
| العنوان: | Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age ; ENEngelskEnglishFunctional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age |
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| المؤلفون: | Humbert, Marion, Olofsson, Anna, Wullimann, David, Niessl, Julia, Hodcroft, Emma B., Cai, Curtis, Gao, Yu, Sohlberg, Ebba, Dyrdak, Robert, Mikaeloff, Flora, Neogi, Ujjwal, Albert, Jan, Malmberg, Karl-Johan, Lund-Johansen, Fridtjof, Aleman, Soo, Björkhem-Bergman, Linda, Jenmalm, Maria C., Ljunggren, Hans-Gustaf, Buggert, Marcus, Karlsson, Annika C. |
| المصدر: | 0027-8424. |
| بيانات النشر: | The National Academy of Sciences |
| سنة النشر: | 2023 |
| المجموعة: | Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
| الوصف: | Significance Our results provide evidence that functional pre-existing SARS-CoV-2-reactive memory CD4+ T cells are elicited in early childhood and linked to seroconversion with the seasonal coronavirus OC43 but not many other viral infections. Compared to other viruses, the high OC43 seroprevalence at age two indicates that memory responses to coronaviruses develop at a young age. The distinct age-dependent profiles of the responding T cells suggest that cross-reactive T cells can contribute to the different clinical outcomes of COVID-19 in children and the elderly. The present results provide important advances regarding antigen-specific memory CD4+ T cell development and maturation, which can help guide future vaccine and therapeutic interventions relating to specificity, function, and phenotype of memory T cell responses throughout the human life span. Abstract Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide evidence that functional cross-reactive memory CD4+ T cell immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is established in early childhood, mirroring early seroconversion with seasonal human coronavirus OC43. Humoral and cellular immune responses against OC43 and SARS-CoV-2 were assessed in SARS-CoV-2-unexposed children (paired samples at age two and six) and adults (age 26 to 83). Pre-existing SARS-CoV-2-reactive CD4+ T cell responses targeting spike, nucleocapsid, and membrane were closely linked to the frequency of OC43-specific memory CD4+ T cells in childhood. The functional quality of the cross-reactive memory CD4+ T cell responses targeting SARS-CoV-2 spike, but not nucleocapsid, paralleled OC43-specific T cell responses. OC43-specific antibodies were prevalent already at age two. However, they did not increase further with age, contrasting with the antibody magnitudes against HKU1 (β-coronavirus), 229E and NL63 (α-coronaviruses), rhinovirus, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Humbert, Marion Olofsson, Anna Wullimann, David Niessl, Julia Hodcroft, Emma B. Cai, Curtis Gao, Yu Sohlberg, Ebba Dyrdak, Robert Mikaeloff, Flora Neogi, Ujjwal Albert, Jan Malmberg, Karl-Johan Lund-Johansen, Fridtjof Aleman, Soo Björkhem-Bergman, Linda Jenmalm, Maria C. Ljunggren, Hans-Gustaf Buggert, Marcus Karlsson, Annika C. . Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age. Proceedings of the National Academy of Sciences of the United States of America. 2023, 120(12); http://hdl.handle.net/10852/106114Test; 2149422; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Proceedings of the National Academy of Sciences of the United States of America&rft.volume=120&rft.spage=&rft.date=2023; Proceedings of the National Academy of Sciences of the United States of America; 120; 12; https://doi.org/10.1073/pnas.2220320120Test |
| DOI: | 10.1073/pnas.2220320120 |
| الإتاحة: | https://doi.org/10.1073/pnas.2220320120Test http://hdl.handle.net/10852/106114Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 International ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.D788FD18 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1073/pnas.2220320120 |
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