دورية أكاديمية
Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium ; ENEngelskEnglishLarge-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium
| العنوان: | Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium ; ENEngelskEnglishLarge-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium |
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| المؤلفون: | Schijven, Dick, Postema, Merel C., Fukunaga, Masaki, Matsumoto, Junya, Miura, Kenichiro, de Zwarte, Sonja M.C., van Haren, Neeltje E.M., Cahn, Wiepke, Hulshoff Pol, Hilleke E., Kahn, René S., Ayesa-Arriola, Rosa, de la Foz, Víctor Ortiz-García, Tordesillas-Gutierrez, Diana, Vázquez-Bourgon, Javier, Crespo-Facorro, Benedicto, Alnæs, Dag, Dahl, Andreas, Westlye, Lars Tjelta, Agartz, Ingrid, Andreassen, Ole, Jönsson, Erik Gunnar, Kochunov, Peter, Bruggemann, Jason M., Catts, Stanley V., Michie, Patricia T., Mowry, Bryan J., Quidé, Yann, Rasser, Paul E., Schall, Ulrich, Scott, Rodney J., Carr, Vaughan J., Green, Melissa J., Henskens, Frans A., Loughland, Carmel M., Pantelis, Christos, Weickert, Cynthia Shannon, Weickert, Thomas W., de Haan, Lieuwe, Brosch, Katharina, Pfarr, Julia-Katharina, Ringwald, Kai G., Stein, Frederike, Jansen, Andreas, Kircher, Tilo T.J., Nenadić, Igor, Krämer, Bernd, Gruber, Oliver, Satterthwaite, Theodore D., Bustillo, Juan, Mathalon, Daniel H., Preda, Adrian, Calhoun, Vince D., Ford, Judith M., Potkin, Steven G., Chen, Jingxu, Tan, Yunlong, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan, Fuentes-Claramonte, Paola, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond, Sarró, Salvador, Pomarol-Clotet, Edith, Ciullo, Valentina, Piras, Fabrizio, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W., Voineskos, Aristotle N., Sim, Kang, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M., Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André, Borgwardt, Stefan, McIntosh, Andrew M., Whalley, Heather C., Lawrie, Stephen M., du Plessis, Stefan, Luckhoff, Hilmar K., Scheffler, Freda, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo, Edmond, Jesse T., Rootes-Murdy, Kelly, Stephen, Julia M., Mayer, Andrew R., Antonucci, Linda A., Fazio, Leonardo, Pergola, Giulio, Bertolino, Alessandro, Díaz-Caneja, Covadonga M., Janssen, Joost, Lois, Noemi G., Arango, Celso, Tomyshev, Alexander S., Lebedeva, Irina, Cervenka, Simon, Sellgren, Carl M., Georgiadis, Foivos, Kirschner, Matthias, Kaiser, Stefan, Hajek, Tomas, Skoch, Antonin, Spaniel, Filip, Kim, Minah, Kwak, Yoo Bin, Oh, Sanghoon, Kwon, Jun Soo, James, Anthony, Bakker, Geor, Knöchel, Christian, Stäblein, Michael, Oertel, Viola, Uhlmann, Anne, Howells, Fleur M., Stein, Dan J., Temmingh, Henk S., Diaz-Zuluaga, Ana M., Pineda-Zapata, Julian A., López-Jaramillo, Carlos, Homan, Stephanie, Ji, Ellen, Surbeck, Werner, Homan, Philipp, Fisher, Simon E., Franke, Barbara, Gur, Ruben C., Glahn, David C., Hashimoto, Ryota, Jahanshad, Neda, Luders, Eileen, Thompson, Paul M., Medland, Sarah E., Turner, Jessica A., van Erp, Theo G.M., Francks, Clyde |
| المصدر: | 0027-8424. |
| بيانات النشر: | The National Academy of Sciences |
| سنة النشر: | 2023 |
| المجموعة: | Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
| الوصف: | Left–right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case–control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case–control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case–control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case–control status. Subtle case–control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Schijven, Dick Postema, Merel C. Fukunaga, Masaki Matsumoto, Junya Miura, Kenichiro de Zwarte, Sonja M.C. van Haren, Neeltje E.M. Cahn, Wiepke Hulshoff Pol, Hilleke E. Kahn, René S. Ayesa-Arriola, Rosa de la Foz, Víctor Ortiz-García Tordesillas-Gutierrez, Diana Vázquez-Bourgon, Javier Crespo-Facorro, Benedicto Alnæs, Dag Dahl, Andreas Westlye, Lars Tjelta Agartz, Ingrid Andreassen, Ole Jönsson, Erik Gunnar Kochunov, Peter Bruggemann, Jason M. Catts, Stanley V. Michie, Patricia T. Mowry, Bryan J. Quidé, Yann Rasser, Paul E. Schall, Ulrich Scott, Rodney J. Carr, Vaughan J. Green, Melissa J. Henskens, Frans A. Loughland, Carmel M. Pantelis, Christos Weickert, Cynthia Shannon Weickert, Thomas W. de Haan, Lieuwe Brosch, Katharina Pfarr, Julia-Katharina Ringwald, Kai G. Stein, Frederike Jansen, Andreas Kircher, Tilo T.J. Nenadić, Igor Krämer, Bernd Gruber, Oliver Satterthwaite, Theodore D. Bustillo, Juan Mathalon, Daniel H. Preda, Adrian Calhoun, Vince D. Ford, Judith M. Potkin, Steven G. Chen, Jingxu Tan, Yunlong Wang, Zhiren Xiang, Hong Fan, Fengmei Bernardoni, Fabio Ehrlich, Stefan Fuentes-Claramonte, Paola Garcia-Leon, Maria Angeles Guerrero-Pedraza, Amalia Salvador, Raymond Sarró, Salvador Pomarol-Clotet, Edith Ciullo, Valentina Piras, Fabrizio Vecchio, Daniela Banaj, Nerisa Spalletta, Gianfranco Michielse, Stijn van Amelsvoort, Therese Dickie, Erin W. Voineskos, Aristotle N. Sim, Kang Ciufolini, Simone Dazzan, Paola Murray, Robin M. Kim, Woo-Sung Chung, Young-Chul Andreou, Christina Schmidt, André Borgwardt, Stefan McIntosh, Andrew M. Whalley, Heather C. Lawrie, Stephen M. du Plessis, Stefan Luckhoff, Hilmar K. Scheffler, Freda Emsley, Robin Grotegerd, Dominik Lencer, Rebekka Dannlowski, Udo Edmond, Jesse T. Rootes-Murdy, Kelly Stephen, Julia M. Mayer, Andrew R. Antonucci, Linda A. Fazio, Leonardo Pergola, Giulio Bertolino, Alessandro Díaz-Caneja, Covadonga M. Janssen, Joost Lois, Noemi G. Arango, Celso Tomyshev, Alexander S. Lebedeva, Irina Cervenka, Simon Sellgren, Carl M. Georgiadis, Foivos Kirschner, Matthias Kaiser, Stefan Hajek, Tomas Skoch, Antonin Spaniel, Filip Kim, Minah Kwak, Yoo Bin Oh, Sanghoon Kwon, Jun Soo James, Anthony Bakker, Geor Knöchel, Christian Stäblein, Michael Oertel, Viola Uhlmann, Anne Howells, Fleur M. Stein, Dan J. Temmingh, Henk S. Diaz-Zuluaga, Ana M. Pineda-Zapata, Julian A. López-Jaramillo, Carlos Homan, Stephanie Ji, Ellen Surbeck, Werner Homan, Philipp Fisher, Simon E. Franke, Barbara Gur, Ruben C. Glahn, David C. Hashimoto, Ryota Jahanshad, Neda Luders, Eileen Thompson, Paul M. Medland, Sarah E. Turner, Jessica A. van Erp, Theo G.M. Francks, Clyde . Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium. Proceedings of the National Academy of Sciences of the United States of America. 2023, 120(14); http://hdl.handle.net/10852/106737Test; 2150697; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Proceedings of the National Academy of Sciences of the United States of America&rft.volume=120&rft.spage=&rft.date=2023; Proceedings of the National Academy of Sciences of the United States of America; 120; 14; https://doi.org/10.1073/pnas.2213880120Test |
| DOI: | 10.1073/pnas.2213880120 |
| الإتاحة: | https://doi.org/10.1073/pnas.2213880120Test http://hdl.handle.net/10852/106737Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.783AB292 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1073/pnas.2213880120 |
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