مورد إلكتروني
An Immunohistological and in Situ Hybridization Study of Arsenical Keratosis
| العنوان: | An Immunohistological and in Situ Hybridization Study of Arsenical Keratosis |
|---|---|
| بيانات النشر: | Niigata University School of Medicine 1996-03 |
| تفاصيل مُضافة: | Fujiwara, Hiroshi Tazawa, Toshio Yamamoto, Ayako Ito, Masaaki |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Arsenical keratosis (AK) is a common early sign of chronic arsenicism. The association between arsenicism and Bowen's disease is well documented, but a definitive understanding of the relation between AK and Bowen's disease remains elusive. In this study, eight cases of AK were examined immunohistologically with antibodies for cytokeratins, epidermal growth factor receptor, erbB2 protein, c-myc protein, and ki-67. An in situ hybridization study for c-myc, v-erb-B, and erbB2 mRNA was also performed. Bowen's disease (16 cases) and normal skin (3 cases) of arsenic ingesters, and Bowen's disease (15 cases) and seborrheic keratosis (15 cases) without arsenic exposure served as controls. AK revealed a similar reaction to Bowen's disease, with characteristic positive cells for ki-67 antigen and c-myc mRNA in the suprabasal layers. These findings demonstrate a close relationship between AK and Bowen's disease. |
| مصطلحات الفهرس: | arsenic, arsenical keratosis, Bowen's disease, 論文(Article), Departmental Bulletin Paper, text |
| URL: | |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | 1890213 bytes application/pdf 論文(Article) English |
| أرقام أخرى: | YN$ oai:dspace.lib.niigata-u.ac.jp:10191/33156 0567-7734 AA00508361 Acta medica et biologica 44 1 37 42 1032319198 |
| المصدر المساهم: | NIIGATA UNIV From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1032319198 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |