1-Bromopropane (1-BP) is used in degreasing solvents and spray adhesives. The adverse effects of 1-BP have been reported in human cases and adult animal models, and its developmental toxicity has also been reported, but its effects on developmental neurotoxicity have not been investigated in detail. We evaluated the effects in rat pups of prenatal exposure to 1-BP on behaviors such as scratching and wet dog shakes (WDS), which were induced by injection of kainate (KA). Pregnant Wistar rats were exposed to vaporized 1-BP with 700 ppm from gestation day 1 to day 20 (6 h/day). KA at doses of 0.1, 0.5, and 2.0 mg/kg were intraperitoneally injected into a control group and a 1-BP-exposed group of pups on postnatal day 14. There was no significant difference in scratching between the control and the prenatally 1-BP-exposed groups, while suppression of the occurrence ratio of WDS was observed at the low dose of 0.1 mg/kg of KA in the prenatally 1-BP-exposed pups. Our results suggest that prenatal exposure to 1-BP affects neurobehavioral responses in the juvenile period. 1-ブロモプロパン（1-BP）は洗浄やスプレー接着剤の溶剤として用いられている．1-BPの有害性はヒトの事例や成獣を用いた動物で報告されてきた．発達毒性も報告されてはいるが，発達神経毒性についての詳細はわかっていない．我々は，1-BPの胎生期曝露が，発達期ラットへのカイニン酸投与により誘導される行動，すなわちscratching行動やwet dog shake様行動に及ぼす影響を調べた．ウィスター系妊娠ラットの妊娠1日目から20日目まで（6時間/日），濃度700 ppmの1-BP蒸気を曝露した．生後14日目の対照群と1-BP曝露群にカイニン酸を0.1，0.5，2.0 mg/kgで腹腔内投与した．Scratching行動に関しては対照群と1-BP曝露群に違いは見られなかったが，wet dog shake 様行動に関しては，低濃度である0.1 mg/kgにおいて発生率の低下が1-BP曝露群で見られた．1-BP胎生期曝露が発達期の神経行動に影響することが示唆された．
