دورية أكاديمية
Associations between urinary paraben levels and obesity of 10-year-old children
| العنوان: | Associations between urinary paraben levels and obesity of 10-year-old children |
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| المؤلفون: | Sinan XU, Jiming ZHANG, Yiming DAI, Zheng WANG, Lei ZHANG, Jianqiu GUO, Xiaojuan QI, Xiuli CHANG, Dasheng LU, Chunhua WU, Zhijun ZHOU |
| المصدر: | 环境与职业医学, Vol 40, Iss 7, Pp 782-787 (2023) |
| بيانات النشر: | Editorial Committee of Journal of Environmental and Occupational Medicine, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) LCC:Toxicology. Poisons |
| مصطلحات موضوعية: | parabens, benzyl-paraben, exposure level, bayesian kernel machine regression, childhood obesity, Medicine (General), R5-920, Toxicology. Poisons, RA1190-1270 |
| الوصف: | BackgroundParabens, a widely used class of preservatives, are suspected to be potential obesogens as emerging endocrine disrupting chemicals with reproductive and developmental toxicity. ObjectiveTo analyze five urinary parabens (PBs) and estimate the associations of exposure to PBs with adiposity measures in 10-year-old school-age children. MethodsA total of 471 school-age children aged 10 years from the Sheyang Mini Birth Cohort were enrolled in this study. A questionnaire survey was conducted to collect socio-demographic information, physical activity, and dietary intake. Weight, height, and waist circumference of children were measured, and age- and sex-adjusted body mass index (BMI-Z score) was calculated. Spot urine samples were collected during the follow-up visits. Urinary concentrations of five PBs including methyl-paraben (MeP), ethyl-paraben (EtP), propyl-paraben (PrP), butyl-paraben (BuP), and benzyl-paraben (BzP) were detected by gas chromatography-tandem mass spectrometry (GC-MS/MS). Generalized linear models (GLMs) and Bayesian kernel machine regression (BKMR) models were applied to estimate associations of individual/overall urinary PBs concentrations with BMI Z-score and waist circumference. ResultsThe positive rates of selected five urinary PBs were in the range from 78.98% to 98.94%. The urinary PBs concentrations (geometric mean) were in the range of 0.31-5.43 μg·L−1. The children's BMI Z-score and waist circumference (mean ± standard deviation) were (0.56±1.40) and (67.62±10.07) cm respectively. The GLMs results showed that the urinary BzP concentration was negatively associated with waist circumference (b=−0.08, 95%CI: −0.14, −0.02; P=0.01). In sex-stratified analysis, the urinary concentration of BzP was negatively associated with BMI-Z score (b=−0.59, 95%CI: −0.88, −0.30; P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Chinese |
| تدمد: | 2095-9982 |
| العلاقة: | http://www.jeom.org/article/cn/10.11836/JEOM23132Test; https://doaj.org/toc/2095-9982Test |
| DOI: | 10.11836/JEOM23132 |
| الوصول الحر: | https://doaj.org/article/5ade0ad9181c45f3aecc3e2664ff8f95Test |
| رقم الانضمام: | edsdoj.5ade0ad9181c45f3aecc3e2664ff8f95 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 20959982 |
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| DOI: | 10.11836/JEOM23132 |