دورية أكاديمية
Non-insulin pharmacological therapies for treating type 1 diabetes
| العنوان: | Non-insulin pharmacological therapies for treating type 1 diabetes |
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| المؤلفون: | Frandsen, Christian Seerup, Dejgaard, Thomas Fremming, Madsbad, Sten, Holst, Jens Juul |
| المصدر: | Frandsen , C S , Dejgaard , T F , Madsbad , S & Holst , J J 2018 , ' Non-insulin pharmacological therapies for treating type 1 diabetes ' , Expert Opinion on Pharmacotherapy , vol. 19 , no. 9 , pp. 947-960 . https://doi.org/10.1080/14656566.2018.1483339Test |
| سنة النشر: | 2018 |
| المجموعة: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| مصطلحات موضوعية: | Type 1 diabetes, T1DM, T1D, pramlintide, amylin, glucagon-like peptide-1, GLP-1RA, dipeptidyl peptidase-4 inhibitor, DPP-4, sodium-glucose cotransporters, SGLT-1, SGLT-2, metformin, sulfonylurea, SU, thiazolidinediones, TZD |
| الوصف: | Introduction: Despite intensified insulin treatment, many persons with type 1 diabetes (T1D) do not achieve glycemic and metabolic targets. Consequently, non-insulin chemical therapies that improve glycemic control and metabolic parameters without increasing the risk of adverse events (including hypoglycemia) are of interest as adjunct therapies to insulin.Areas covered: In this review, the authors discuss the efficacy and safety of non-insulin therapies, including pramlintide, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 inhibitors (DPP-4), sodium-glucose cotransporter (SGLT1 and SGLT2) inhibitors, metformin, sulfonylureas, and thiazolidinediones as add-on therapies to insulin in T1D.Expert opinion: The current evidence shows that the efficacy of non-insulin therapies as add-on therapies to insulin is minimal or modest with an average HbA1c reduction of 0.2-0.5% (2-6mmol/mol). Indeed, the current focus is on the development of SGLT inhibitors as adjuncts to insulin in type 1 diabetes. Studies of subgroups with obesity, residual beta-cell function (including newly diagnosed patients) and patients prone to hypoglycemia could be areas of future research. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1080/14656566.2018.1483339 |
| الإتاحة: | https://doi.org/10.1080/14656566.2018.1483339Test https://curis.ku.dk/portal/da/publications/noninsulin-pharmacological-therapies-for-treating-type-1-diabetesTest(18d0ea78-3d4a-4aad-9cbf-87dad6777cb8).html |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.AE8DABDC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/14656566.2018.1483339 |
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