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1دورية أكاديمية
المؤلفون: Leijten-van de Gevel, Iris A., van Herk, Kim H.N., de Vries, Rens M.J.M., Ottenheym, Nicolaas J., Ottmann, Christian, Brunsveld, Luc
المصدر: Leijten-van de Gevel , I A , van Herk , K H N , de Vries , R M J M , Ottenheym , N J , Ottmann , C & Brunsveld , L 2022 , ' Indazole MRL-871 interacts with PPARγ via a binding mode that induces partial agonism ' , Bioorganic and Medicinal Chemistry , vol. 68 , 116877 . https://doi.org/10.1016/j.bmc.2022.116877Test
مصطلحات موضوعية: Co-crystal structure, Nuclear Receptors, Partial Agonism, PPARγ, RORγt, Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism, Protein Structure, Secondary, PPAR gamma/agonists, Indazoles/pharmacology, Ligands
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1016/j.bmc.2022.116877Test
https://research.tue.nl/en/publications/a3a998b0-c575-433d-a230-7f4bc2b62470Test
https://pure.tue.nl/ws/files/211567189/1_s2.0_S0968089622002693_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85131964889&partnerID=8YFLogxKTest -
2دورية أكاديمية
المؤلفون: Leijten-van de Gevel, Iris A., van Herk, Kim H.N., de Vries, Rens M.J.M., Ottenheym, Nicolaas J., Ottmann, Christian, Brunsveld, Luc
المصدر: Leijten-van de Gevel , I A , van Herk , K H N , de Vries , R M J M , Ottenheym , N J , Ottmann , C & Brunsveld , L 2022 , ' Indazole MRL-871 interacts with PPARγ via a binding mode that induces partial agonism ' , Bioorganic and Medicinal Chemistry , vol. 68 , 116877 . https://doi.org/10.1016/j.bmc.2022.116877Test
مصطلحات موضوعية: Co-crystal structure, Nuclear Receptors, Partial Agonism, PPARγ, RORγt, Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism, Protein Structure, Secondary, PPAR gamma/agonists, Indazoles/pharmacology, Ligands
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1016/j.bmc.2022.116877Test
https://research.tue.nl/en/publications/a3a998b0-c575-433d-a230-7f4bc2b62470Test
https://pure.tue.nl/ws/files/211567189/1_s2.0_S0968089622002693_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85131964889&partnerID=8YFLogxKTest -
3دورية أكاديمية
المؤلفون: Meijer, Femke A., van den Oetelaar, M.C.M., Doveston, R.G., Sampers, E.N.R., Brunsveld, Lucas
المصدر: Meijer , F A , van den Oetelaar , M C M , Doveston , R G , Sampers , E N R & Brunsveld , L 2021 , ' Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site ' , ACS Medicinal Chemistry Letters , vol. 12 , no. 4 , pp. 631-639 . https://doi.org/10.1021/acsmedchemlett.1c00029Test
مصطلحات موضوعية: Nuclear receptors, RORγt, allosteric modulators, covalent probes
الإتاحة: https://doi.org/10.1021/acsmedchemlett.1c00029Test
https://research.tue.nl/en/publications/f2123ce0-8a26-4073-92e2-dd92e65e640aTest
http://www.scopus.com/inward/record.url?scp=85103476297&partnerID=8YFLogxKTest -
4دورية أكاديمية
المؤلفون: Meijer, Femke A., van den Oetelaar, M.C.M., Doveston, R.G., Sampers, E.N.R., Brunsveld, Lucas
المصدر: Meijer , F A , van den Oetelaar , M C M , Doveston , R G , Sampers , E N R & Brunsveld , L 2021 , ' Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site ' , ACS Medicinal Chemistry Letters , vol. 12 , no. 4 , pp. 631-639 . https://doi.org/10.1021/acsmedchemlett.1c00029Test
مصطلحات موضوعية: Nuclear receptors, RORγt, allosteric modulators, covalent probes
الإتاحة: https://doi.org/10.1021/acsmedchemlett.1c00029Test
https://research.tue.nl/en/publications/f2123ce0-8a26-4073-92e2-dd92e65e640aTest
http://www.scopus.com/inward/record.url?scp=85103476297&partnerID=8YFLogxKTest -
5دورية أكاديمية
المصدر: de Vries , R M J M , Doveston , R G , Meijer , F A & Brunsveld , L 2020 , ' Elucidation of an allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist ' , ChemMedChem , vol. 15 , no. 7 , pp. 561-565 . https://doi.org/10.1002/cmdc.202000044Test
مصطلحات موضوعية: Nuclear Receptors, RORγt, Allosteric Modulators, Structure Elucidation, Drug Discovery, ROR gamma t
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1002/cmdc.202000044Test
https://research.tue.nl/en/publications/0bf721e3-eff7-43da-9dfb-10538bae9ae5Test
https://pure.tue.nl/ws/files/149174502/cmdc.202000044.pdfTest
http://www.scopus.com/inward/record.url?scp=85081956966&partnerID=8YFLogxKTest -
6دورية أكاديمية
المؤلفون: Leijten-van de Gevel, Iris A, Brunsveld, Luc
المصدر: Leijten-van de Gevel , I A & Brunsveld , L 2020 , ' Delineation of the molecular determinants of the unique allosteric binding site of the orphan nuclear receptor RORγt ' , Journal of Biological Chemistry , vol. 295 , no. 27 , pp. 9183-9191 . https://doi.org/10.1074/jbc.RA120.013581Test
مصطلحات موضوعية: allosteric regulation, autoimmune disease, drug action, inverse agonism, inverse agonist, ligand-binding domain (LBD), ligand-binding protein, molecular pharmacology, nuclear receptor, retinoic acid receptor-related orphan receptor-γt (RORγt), structure-function, transcriptional regulation
الإتاحة: https://doi.org/10.1074/jbc.RA120.013581Test
https://research.tue.nl/en/publications/216eb69c-6f2a-4d16-ac57-e8edd96f54d7Test
http://www.scopus.com/inward/record.url?scp=85087529860&partnerID=8YFLogxKTest -
7دورية أكاديمية
المؤلفون: Leijten-van de Gevel, Iris A, Brunsveld, Luc
المصدر: Leijten-van de Gevel , I A & Brunsveld , L 2020 , ' Delineation of the molecular determinants of the unique allosteric binding site of the orphan nuclear receptor RORγt ' , Journal of Biological Chemistry , vol. 295 , no. 27 , pp. 9183-9191 . https://doi.org/10.1074/jbc.RA120.013581Test
مصطلحات موضوعية: allosteric regulation, autoimmune disease, drug action, inverse agonism, inverse agonist, ligand-binding domain (LBD), ligand-binding protein, molecular pharmacology, nuclear receptor, retinoic acid receptor-related orphan receptor-γt (RORγt), structure-function, transcriptional regulation
الإتاحة: https://doi.org/10.1074/jbc.RA120.013581Test
https://research.tue.nl/en/publications/216eb69c-6f2a-4d16-ac57-e8edd96f54d7Test
http://www.scopus.com/inward/record.url?scp=85087529860&partnerID=8YFLogxKTest -
8دورية أكاديمية
المصدر: de Vries , R M J M , Doveston , R G , Meijer , F A & Brunsveld , L 2020 , ' Elucidation of an allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist ' , ChemMedChem , vol. 15 , no. 7 , pp. 561-565 . https://doi.org/10.1002/cmdc.202000044Test
مصطلحات موضوعية: Nuclear Receptors, RORγt, Allosteric Modulators, Structure Elucidation, Drug Discovery, ROR gamma t
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1002/cmdc.202000044Test
https://research.tue.nl/en/publications/0bf721e3-eff7-43da-9dfb-10538bae9ae5Test
https://pure.tue.nl/ws/files/149174502/cmdc.202000044.pdfTest
http://www.scopus.com/inward/record.url?scp=85081956966&partnerID=8YFLogxKTest