دورية أكاديمية
Medium chain acyl-CoA dehydrogenase deficiency and fatal valproate toxicity
| العنوان: | Medium chain acyl-CoA dehydrogenase deficiency and fatal valproate toxicity |
|---|---|
| المؤلفون: | Njolstad, PR, Skjeldal, OH, Agsteribbe, E, Huckriede, A, Wannag, E, Sovik, O, Waaler, PE |
| المصدر: | Njolstad , PR , Skjeldal , OH , Agsteribbe , E , Huckriede , A , Wannag , E , Sovik , O & Waaler , PE 1997 , ' Medium chain acyl-CoA dehydrogenase deficiency and fatal valproate toxicity ' , Pediatric neurology , vol. 16 , no. 2 , pp. 160-162 . |
| سنة النشر: | 1997 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | HEPATOTOXICITY, CHILDREN, THERAPY, FAILURE |
| الوصف: | A boy with delayed psychomotor development, attention deficit disorder, and therapy-resistant epilepsy was treated with valproate. The patient died of liver failure after 4 months of valproate treatment. Postmortem investigation of cultured fibroblasts suggested medium chain acyl-CoA dehydrogenase deficiency, an unexpected finding since the boy had not presented typical manifestations of this disease. Because medium chain acyl-CoA dehydrogenase is an important enzyme in the beta-oxidation of fatty acids, our patient probably had a genetically reduced tolerance to valproate. This drug should be omitted in the treatment of seizures in patients with possible medium chain acyl-CoA dehydrogenase deficiency. (C) 1997 by Elsevier Science Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/50d326b6-627e-4b0c-89b8-052e87af22fdTest |
| الإتاحة: | https://hdl.handle.net/11370/50d326b6-627e-4b0c-89b8-052e87af22fdTest https://research.rug.nl/en/publications/50d326b6-627e-4b0c-89b8-052e87af22fdTest |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.6E88A998 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |