دورية أكاديمية
Maintenance avelumab versus continuation of first-line chemotherapy in gastric cancer:JAVELIN Gastric 100 study design
| العنوان: | Maintenance avelumab versus continuation of first-line chemotherapy in gastric cancer:JAVELIN Gastric 100 study design |
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| المؤلفون: | Moehler, Markus, Ryu, Min Hee, Dvorkin, Mikhail, Lee, Keun Wook, Coşkun, Hasan, Wong, Rachel, Chung, Hyun C., Poltoratsky, Artem, Tsuji, Akihito, Yen, Chia Jui, Muntean, Alina S., Le Sourd, Samuel, Vaccaro, Gina M., Overton, Lindsay, Boku, Narikazu, Wainberg, Zev A., Patel, Manish, Sharma, Maitreyi, Xiong, Huiling, Conti, Ilaria, Taieb, Julien, Bang, Yung Jue |
| المصدر: | Moehler , M , Ryu , M H , Dvorkin , M , Lee , K W , Coşkun , H , Wong , R , Chung , H C , Poltoratsky , A , Tsuji , A , Yen , C J , Muntean , A S , Le Sourd , S , Vaccaro , G M , Overton , L , Boku , N , Wainberg , Z A , Patel , M , Sharma , M , Xiong , H , Conti , I , Taieb , J & Bang , Y J 2019 , ' .... |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | avelumab, gastric cancer, PD-L1 |
| الوصف: | Avelumab is a human anti-PD-L1 IgG1 monoclonal antibody that has shown antitumor activity in early phase studies in advanced/metastatic gastric/gastroesophageal junction cancer, including as first-line maintenance therapy. Here, we describe the design of JAVELIN Gastric 100 (NCT02625610), an open-label, Phase III trial. A total of 499 patients with locally advanced/metastatic HER2- gastric/gastroesophageal junction cancer adenocarcinoma, who had achieved at least stable disease following 12 weeks of first-line oxaliplatin/fluoropyrimidine chemotherapy, have been randomized 1:1 to receive avelumab maintenance therapy or continue chemotherapy. The primary objective is to demonstrate superior overall survival in all randomized patients or in the PD-L1+ population. Secondary objectives are to demonstrate superiority for progression-free survival and objective response rate, compare quality of life measures, and determine safety. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.2217/fon-2018-0668 |
| الإتاحة: | https://doi.org/10.2217/fon-2018-0668Test https://research.monash.edu/en/publications/58b61b7c-f9fd-4091-a9b2-34b8951bbed3Test https://researchmgt.monash.edu/ws/files/288520579/261613500_oa.pdfTest http://www.scopus.com/inward/record.url?scp=85061250794&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6442B009 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2217/fon-2018-0668 |
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