دورية أكاديمية
Unusual severe case of hemolytic uremic syndrome due to Shiga toxin 2d-producing E. coli O80:H2
| العنوان: | Unusual severe case of hemolytic uremic syndrome due to Shiga toxin 2d-producing E. coli O80:H2 |
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| المؤلفون: | Wijnsma, Kioa L, Schijvens, Anne M, Rossen, John W A, Kooistra-Smid, A M D Mirjam, Schreuder, Michiel F, van de Kar, Nicole C A J |
| المصدر: | Wijnsma , K L , Schijvens , A M , Rossen , J W A , Kooistra-Smid , A M D M , Schreuder , M F & van de Kar , N C A J 2017 , ' Unusual severe case of hemolytic uremic syndrome due to Shiga toxin 2d-producing E. coli O80:H2 ' , Pediatric Nephrology , vol. 32 , no. 7 , pp. 1263-1268 . https://doi.org/10.1007/s00467-017-3642-3Test |
| سنة النشر: | 2017 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | Hemolytic uremic syndrome, STEC-HUS, Serotype O80:H2, NEUROLOGICAL INVOLVEMENT, ECULIZUMAB, HUS |
| الوصف: | Hemolytic uremic syndrome (HUS) is one of the most common causes of acute renal failure in children, with the majority of cases caused by an infection with Shiga toxin-producing Escherichia coli (STEC). Whereas O157 is still the predominant STEC serotype, non-O157 serotypes are increasingly associated with STEC-HUS. However, little is known about this emerging and highly diverse group of non-O157 serotypes. With supportive therapy, STEC-HUS is often self-limiting, with occurrence of chronic sequelae in just a small proportion of patients. In this case report, we describe a 16-month-old boy with a highly severe and atypical presentation of STEC-HUS. Despite the presentation with multi-organ failure and extensive involvement of central nervous system due to extensive thrombotic microangiopathy (suggestive of atypical HUS), fecal diagnostics revealed an infection with the rare serotype: shiga toxin 2d-producing STEC O80:H2. This report underlines the importance of STEC diagnostic tests in all children with HUS, including those with an atypical presentation, and emphasizes the importance of molecular and serotyping assays to estimate the virulence of an STEC strain. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/b6d3cda9-da34-4fb6-b3bc-3389af6f9016Test |
| DOI: | 10.1007/s00467-017-3642-3 |
| الإتاحة: | https://doi.org/10.1007/s00467-017-3642-3Test https://hdl.handle.net/11370/b6d3cda9-da34-4fb6-b3bc-3389af6f9016Test https://research.rug.nl/en/publications/b6d3cda9-da34-4fb6-b3bc-3389af6f9016Test https://pure.rug.nl/ws/files/42620506/Unusual_severe_case_of_hemolytic_uremic_syndrome_due_to_Shiga_toxin_2d_producing.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2065ED04 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00467-017-3642-3 |
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