دورية أكاديمية
Stress biology:Complexity and multifariousness in health and disease
| العنوان: | Stress biology:Complexity and multifariousness in health and disease |
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| المؤلفون: | Mayer, Matthias P., Blair, Laura, Blatch, Gregory L., Borges, Thiago J., Chadli, Ahmed, Chiosis, Gabriela, de Thonel, Aurélie, Dinkova-Kostova, Albena, Ecroyd, Heath, Edkins, Adrienne L., Eguchi, Takanori, Fleshner, Monika, Foley, Kevin P., Fragkostefanakis, Sotirios, Gestwicki, Jason, Goloubinoff, Pierre, Heritz, Jennifer A., Heske, Christine M., Hibshman, Jonathan D., Joutsen, Jenny, Li, Wei, Lynes, Michael, Mendillo, Marc L., Mivechi, Nahid, Mokoena, Fortunate, Okusha, Yuka, Prahlad, Veena, Repasky, Elizabeth, Sannino, Sara, Scalia, Federica, Shalgi, Reut, Sistonen, Lea, Sontag, Emily, van Oosten-Hawle, Patricija, Vihervaara, Anniina, Wickramaratne, Anushka, Wang, Shawn Xiang Yang, Zininga, Tawanda |
| المصدر: | Mayer , M P , Blair , L , Blatch , G L , Borges , T J , Chadli , A , Chiosis , G , de Thonel , A , Dinkova-Kostova , A , Ecroyd , H , Edkins , A L , Eguchi , T , Fleshner , M , Foley , K P , Fragkostefanakis , S , Gestwicki , J , Goloubinoff , P , Heritz , J A , Heske , C M , Hibshman , J D , Joutsen , J , Li , W , Lynes , M , Mendillo , .... |
| سنة النشر: | 2024 |
| المجموعة: | Discovery - University of Dundee Online Publications |
| مصطلحات موضوعية: | Heat shock proteins, Heat shock response, Heat shock transcription factors, Molecular chaperones, Protein folding diseases, Stress response, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1307, name=Cell Biology |
| الوصف: | Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://discovery.dundee.ac.uk/en/publications/573ec391-9d33-4b75-9c0a-91e7c58f5f62Test |
| DOI: | 10.1016/j.cstres.2024.01.006 |
| الإتاحة: | https://doi.org/10.1016/j.cstres.2024.01.006Test https://discovery.dundee.ac.uk/en/publications/573ec391-9d33-4b75-9c0a-91e7c58f5f62Test https://discovery.dundee.ac.uk/ws/files/120540180/1-s2.0-S1355814524000464-main.pdfTest http://www.scopus.com/inward/record.url?scp=85185460130&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FAD1CC46 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cstres.2024.01.006 |
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