المؤلفون: Abd-Elaziz, Khalid, Voors-Pette, Christine, Wang, Kang Ling, Pan, Sandy, Lee, Yisheng, Mao, John, Li, Yuhua, Chien, Benjamin, Lau, David, Diamant, Zuzana

المصدر: Abd-Elaziz , K , Voors-Pette , C , Wang , K L , Pan , S , Lee , Y , Mao , J , Li , Y , Chien , B , Lau , D & Diamant , Z 2021 , ' First-in-Man Safety, Tolerability, and Pharmacokinetics of a Novel and Highly Selective Inhibitor of Matrix Metalloproteinase-12, FP-025 : Results from Two Randomized Studies in Healthy Subjects ' , Clinical Drug investigation , vol. 41 , pp. 65-76 . https://doi.org/10.1007/s40261-020-00981-9Test

مصطلحات موضوعية: Adult, Area Under Curve, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Matrix Metalloproteinase 12/drug effects, Matrix Metalloproteinase Inhibitors/administration & dosage, Young Adult

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/cd450430-dfe3-4226-bdea-e797b8b23e84Test

الإتاحة: https://doi.org/10.1007/s40261-020-00981-9Test
https://hdl.handle.net/11370/cd450430-dfe3-4226-bdea-e797b8b23e84Test
https://research.rug.nl/en/publications/cd450430-dfe3-4226-bdea-e797b8b23e84Test
https://pure.rug.nl/ws/files/632784246/s40261_020_00981_9.pdfTest
http://www.scopus.com/inward/record.url?scp=85097679660&partnerID=8YFLogxKTest

المؤلفون: Abd-Elaziz, Khalid, Jesenak, Milos, Vasakova, Martina, Diamant, Zuzana

المصدر: Abd-Elaziz , K , Jesenak , M , Vasakova , M & Diamant , Z 2021 , ' Revisiting matrix metalloproteinase 12 : its role in pathophysiology of asthma and related pulmonary diseases ' , Current Opinion in Pulmonary Medicine , vol. 27 , no. 1 , pp. 54-60 . https://doi.org/10.1097/MCP.0000000000000743Test

مصطلحات موضوعية: Animals, Asthma/drug therapy, Biomarkers/metabolism, COVID-19/enzymology, Humans, Idiopathic Pulmonary Fibrosis/drug therapy, Matrix Metalloproteinase 12/metabolism, Matrix Metalloproteinase Inhibitors/therapeutic use, Pulmonary Disease, Chronic Obstructive/drug therapy, COVID-19 Drug Treatment

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/239194cb-0935-4860-a9b5-cfe7b24c9a4aTest

الإتاحة: https://doi.org/10.1097/MCP.0000000000000743Test
https://hdl.handle.net/11370/239194cb-0935-4860-a9b5-cfe7b24c9a4aTest
https://research.rug.nl/en/publications/239194cb-0935-4860-a9b5-cfe7b24c9a4aTest
https://pure.rug.nl/ws/files/192308869/Revisiting_matrix_metalloproteinase_12_its_role.10.pdfTest

المؤلفون: Harwood, Seandean Lykke, Nielsen, Nadia Sukusu, Diep, Khang, Jensen, Kathrine Tejlgård, Nielsen, Peter Kresten, Yamamoto, Kazuhiro, Enghild, Jan J.

المصدر: Harwood , S L , Nielsen , N S , Diep , K , Jensen , K T , Nielsen , P K , Yamamoto , K & Enghild , J J 2021 , ' Development of selective protease inhibitors via engineering of the bait region of human α2-macroglobulin ' , The Journal of Biological Chemistry , vol. 297 , no. 1 , 100879 . https://doi.org/10.1016/j.jbc.2021.100879Test

مصطلحات موضوعية: CLEAVAGE SITES, COMPONENT C4, CRYSTAL-STRUCTURE, FAST FORMS, HUMAN ALPHA-2-MACROGLOBULIN, HUMAN PLASMA, MATRIX-METALLOPROTEINASE INHIBITORS, PROTEOLYTIC ACTIVITIES, STRUCTURAL BASIS, SUBSTRATE RECOGNITION

الإتاحة: https://doi.org/10.1016/j.jbc.2021.100879Test
https://pure.au.dk/portal/da/publications/development-of-selective-proteaseTest-inhibitors-via-engineering-of-the-bait-region-of-human-2macroglobulin(641a705c-e15b-4647-9d9a-045bea830fd7).html
http://www.scopus.com/inward/record.url?scp=85109442842&partnerID=8YFLogxKTest

المؤلفون: Gibson, Rachel J, van Sebille, Ysabella Z A, Wardill, Hannah R, Wignall, Anthony, Shirren, Joseph, Ball, Imogen A, Williams, Nicole, Wanner, Kiara, Bowen, Joanne M

المصدر: Gibson , R J , van Sebille , Y Z A , Wardill , H R , Wignall , A , Shirren , J , Ball , I A , Williams , N , Wanner , K & Bowen , J M 2018 , ' Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat Model ' , Chemotherapy , vol. 63 , no. 5 , pp. 284-292 . https://doi.org/10.1159/000495470Test

مصطلحات موضوعية: Animals, Antimetabolites, Antineoplastic/adverse effects, Cell Line, Tumor, Diarrhea/etiology, Female, Humans, Intestinal Mucosa/pathology, Matrix Metalloproteinase Inhibitors/adverse effects, Matrix Metalloproteinases/chemistry, Methotrexate/adverse effects, Neoplasms/drug therapy, Organic Chemicals/adverse effects, Random Allocation, Rats, Transplantation, Heterologous

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/2567f6ab-4835-45b2-a3de-1ffd83e4bdbdTest

الإتاحة: https://doi.org/10.1159/000495470Test
https://hdl.handle.net/11370/2567f6ab-4835-45b2-a3de-1ffd83e4bdbdTest
https://research.rug.nl/en/publications/2567f6ab-4835-45b2-a3de-1ffd83e4bdbdTest
https://pure.rug.nl/ws/files/79452813/Selective_MMP_Inhibition_Using_AZD3342_to_Reduce_Gastrointestinal_Toxicity_and_Enhance_Chemoefficacy_in_a_Rat_Model.pdfTest

المؤلفون: Nienhuis, H. H., Gaykema, S. B. M., Timmer-Bosscha, H., Jalving, M., Brouwers, A. H., Lub-de Hooge, M. N., van der Vegt, B., Overmoyer, B., de Vries, E. G. E., Schröder, C. P.

المصدر: Nienhuis , H H , Gaykema , S B M , Timmer-Bosscha , H , Jalving , M , Brouwers , A H , Lub-de Hooge , M N , van der Vegt , B , Overmoyer , B , de Vries , E G E & Schröder , C P 2015 , ' Targeting breast cancer through its microenvironment : Current status of preclinical and clinical research in finding relevant targets ' , Pharmacology & Therapeutics , vol. 147 , pp. 63-79 . https://doi.org/10.1016/j.pharmthera.2014.11.004Test

مصطلحات موضوعية: Microenvironment, Breast cancer, Targeted therapy, Biomarkers, Metastasis, Metabolism, ENDOTHELIAL GROWTH-FACTOR, BODY-MASS INDEX, TYROSINE KINASE INHIBITOR, MATRIX-METALLOPROTEINASE INHIBITORS, POSITRON-EMISSION-TOMOGRAPHY, TUMOR-ASSOCIATED MACROPHAGES, MAMMARY-GLAND DEVELOPMENT, EPITHELIAL-MESENCHYMAL TRANSITION, BEVACIZUMAB-CONTAINING THERAPY, ADJUVANT ENDOCRINE THERAPY

العلاقة: https://research.rug.nl/en/publications/36cb99c4-4bfc-49a2-a660-25a264d443e4Test

الإتاحة: https://doi.org/10.1016/j.pharmthera.2014.11.004Test
https://hdl.handle.net/11370/36cb99c4-4bfc-49a2-a660-25a264d443e4Test
https://research.rug.nl/en/publications/36cb99c4-4bfc-49a2-a660-25a264d443e4Test

المؤلفون: Hu, Jie Hong, Touch, Phanith, Zhang, Jingwan, Wei, Hao, Liu, Shihui, Lund, Ida K, Høyer-Hansen, Gunilla, Dichek, David A

المصدر: Hu , J H , Touch , P , Zhang , J , Wei , H , Liu , S , Lund , I K , Høyer-Hansen , G & Dichek , D A 2015 , ' Reduction of mouse atherosclerosis by urokinase inhibition or with a limited-spectrum matrix metalloproteinase inhibitor ' , Cardiovascular Research , vol. 105 , no. 3 , pp. 372-82 . https://doi.org/10.1093/cvr/cvv007Test

مصطلحات موضوعية: Animals, Aorta, Aortic Diseases, Apolipoproteins E, Atherosclerosis, Dilatation, Pathologic, Disease Models, Animal, Lipids, Macrophages, Male, Matrix Metalloproteinase 13, Matrix Metalloproteinase Inhibitors, Mice, Inbred C57BL, Knockout, Transgenic, Serine Proteinase Inhibitors, Urokinase-Type Plasminogen Activator, Journal Article, Research Support, N.I.H., Extramural, Non-U.S. Gov't

الإتاحة: https://doi.org/10.1093/cvr/cvv007Test
https://curis.ku.dk/portal/da/publications/reduction-of-mouse-atherosclerosis-by-urokinase-inhibition-or-with-a-limitedspectrumTest-matrix-metalloproteinase-inhibitor(6bc01a9c-a04b-43d9-a9cc-ef6d857c9606).html

المؤلفون: Newby, Andrew C

المصدر: Newby , A C 2014 , ' Proteinases and plaque rupture : unblocking the road to translation ' , Current Opinion in Lipidology , vol. 25 , no. 5 , pp. 358-66 . https://doi.org/10.1097/MOL.0000000000000111Test

مصطلحات موضوعية: ADAM Proteins, Amyloid Precursor Protein Secretases, Atherosclerosis, Cathepsin K, Genome-Wide Association Study, Humans, Macrophages, Matrix Metalloproteinase Inhibitors, Matrix Metalloproteinases, Membrane Proteins, Molecular Targeted Therapy, Myocardial Infarction, Plaque, Atherosclerotic

العلاقة: https://research-information.bris.ac.uk/en/publications/c7764c0c-a88b-4861-80c7-4df3f63c7b3fTest

الإتاحة: https://doi.org/10.1097/MOL.0000000000000111Test
https://hdl.handle.net/1983/c7764c0c-a88b-4861-80c7-4df3f63c7b3fTest
https://research-information.bris.ac.uk/en/publications/c7764c0c-a88b-4861-80c7-4df3f63c7b3fTest

المؤلفون: Gaublomme, Djoere, Buyens, Tom, De Groef, Lies, Stakenborg, Michelle, Janssens, Els, Ingvarsen, Signe, Porse, Astrid, Behrendt, Niels, Moons, Lieve

المصدر: Gaublomme , D , Buyens , T , De Groef , L , Stakenborg , M , Janssens , E , Ingvarsen , S , Porse , A , Behrendt , N & Moons , L 2014 , ' Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells ' , Journal of Neurochemistry , vol. 129 , no. 6 , pp. 966-979 . https://doi.org/10.1111/jnc.12703Test

مصطلحات موضوعية: Animals, Antibodies, Blocking, Antigens, CD29, Axons, Gelatinases, Image Processing, Computer-Assisted, Immunohistochemistry, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Matrix Metalloproteinase Inhibitors, Matrix Metalloproteinases, Membrane-Associated, Mice, Inbred C57BL, Knockout, Organ Culture Techniques, Retinal Ganglion Cells, Signal Transduction

الإتاحة: https://doi.org/10.1111/jnc.12703Test
https://curis.ku.dk/portal/da/publicationsTest/matrix-metalloproteinase-2-and-membrane-type-1-matrix-metalloproteinase-coregulate-axonal-outgrowth-of-mouse-retinal-ganglion-cells(3581f41f-a4e3-4777-88d0-b8344415c0dd).html

المؤلفون: Krarup, Peter-Martin, Eld, Mikkel, Heinemeier, Katja Maria, Jorgensen, Lars Nannestad, Hansen, Mark Berner, Ågren, Magnus

المصدر: Krarup , P-M , Eld , M , Heinemeier , K M , Jorgensen , L N , Hansen , M B & Ågren , M 2013 , ' Expression and inhibition of matrix metalloproteinase (MMP)-8, MMP-9 and MMP-12 in early colonic anastomotic repair ' , International Journal of Colorectal Disease , vol. 28 , no. 8 , pp. 1151-1159 . https://doi.org/10.1007/s00384-013-1697-6Test

مصطلحات موضوعية: Anastomosis, Surgical, Animals, Collagen, Colon, Gene Expression Regulation, Enzymologic, Male, Matrix Metalloproteinase 12, Matrix Metalloproteinase 8, Matrix Metalloproteinase 9, Matrix Metalloproteinase Inhibitors, Rats, Sprague-Dawley, Wound Healing

العلاقة: https://vbn.aau.dk/da/publications/45db1d6c-cb13-4fdc-bb41-ef08e4edecf1Test

الإتاحة: https://doi.org/10.1007/s00384-013-1697-6Test
https://vbn.aau.dk/da/publications/45db1d6c-cb13-4fdc-bb41-ef08e4edecf1Test
http://www.scopus.com/inward/record.url?scp=84883551523&partnerID=8YFLogxKTest

المؤلفون: Almahdy, A, Koller, G, Sauro, S, Bartsch, J W, Sherriff, M, Watson, T F, Banerjee, A

المصدر: Almahdy , A , Koller , G , Sauro , S , Bartsch , J W , Sherriff , M , Watson , T F & Banerjee , A 2012 , ' Effects of MMP inhibitors incorporated within dental adhesives ' , Journal of Dental Research , vol. 91 , no. 6 , pp. 605-11 . https://doi.org/10.1177/0022034512446339Test

مصطلحات موضوعية: Adolescent, Adult, Dental Bonding, Dental Leakage, Dental Stress Analysis, Dentin, Dentin-Bonding Agents, Dipeptides, Humans, Logistic Models, Materials Testing, Matrix Metalloproteinase Inhibitors, Methacrylates, Molar, Phenylalanine, Polymethacrylic Acids, Resin Cements, Tensile Strength, Thiophenes, Young Adult

العلاقة: https://research-information.bris.ac.uk/en/publications/565d5f6d-b423-4523-8c14-696033501dd0Test

الإتاحة: https://doi.org/10.1177/0022034512446339Test
https://hdl.handle.net/1983/565d5f6d-b423-4523-8c14-696033501dd0Test
https://research-information.bris.ac.uk/en/publications/565d5f6d-b423-4523-8c14-696033501dd0Test