المؤلفون: Messier, Stephen P., Callahan, Leigh F., Losina, Elena, Mihalko, Shannon L., Guermazi, Ali, Ip, Edward, Miller, Gary D., Katz, Jeffrey N., Loeser, Richard F., Pietrosimone, Brian G., Soto, Sandra, Cook, James L., Newman, Jovita J., DeVita, Paul, Spindler, Kurt P., Runhaar, Jos, Armitano-Lago, Cortney, Duong, Vicky, Selzer, Faith, Hill, Ryan, Love, Monica, Beavers, Daniel P., Saldana, Santiago, Stoker, Aaron M., Rice, Paige E., Hunter, David J.

المصدر: Messier , S P , Callahan , L F , Losina , E , Mihalko , S L , Guermazi , A , Ip , E , Miller , G D , Katz , J N , Loeser , R F , Pietrosimone , B G , Soto , S , Cook , J L , Newman , J J , DeVita , P , Spindler , K P , Runhaar , J , Armitano-Lago , C , Duong , V , Selzer , F , Hill , R , Love , M , Beavers , D P , ....

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الوصف: Background: Osteoarthritis (OA), the leading cause of disability among adults, has no cure and is associated with significant comorbidities. The premise of this randomized clinical trial is that, in a population at risk, a 48-month program of dietary weight loss and exercise will result in less incident structural knee OA compared to control. Methods/design: The Osteoarthritis Prevention Study (TOPS) is a Phase III, assessor-blinded, 48-month, parallel 2 arm, multicenter randomized clinical trial designed to reduce the incidence of structural knee OA. The study objective is to assess the effects of a dietary weight loss, exercise, and weight-loss maintenance program in preventing the development of structural knee OA in females at risk for the disease. TOPS will recruit 1230 ambulatory, community dwelling females with obesity (Body Mass Index (BMI) ≥ 30 kg/m 2 ) and aged ≥50 years with no radiographic (Kellgren-Lawrence grade ≤1) and no magnetic resonance imaging (MRI) evidence of OA in the eligible knee, with no or infrequent knee pain. Incident structural knee OA (defined as tibiofemoral and/or patellofemoral OA on MRI) assessed at 48-months from intervention initiation using the MRI Osteoarthritis Knee Score (MOAKS) is the primary outcome. Secondary outcomes include knee pain, 6-min walk distance, health-related quality of life, knee joint loading during gait, inflammatory biomarkers, and self-efficacy. Cost effectiveness and budgetary impact analyses will determine the value and affordability of this intervention. Discussion: This study will assess the efficacy and cost effectiveness of a dietary weight loss, exercise, and weight-loss maintenance program designed to reduce incident knee OA. Trial registration: ClinicalTrials.gov Identifier: NCT05946044.

وصف الملف: application/pdf

العلاقة: https://pure.eur.nl/en/publications/4f47dedb-a38f-4ef4-8b6f-9146d78ba487Test

الإتاحة: https://doi.org/10.1016/j.ocarto.2023.100418Test
https://pure.eur.nl/en/publications/4f47dedb-a38f-4ef4-8b6f-9146d78ba487Test
https://pure.eur.nl/ws/files/124162103/The_osteoarthritis_prevention_study_TOPS_-_A_randomized_controlled_trial_of_diet_and_exercise_to_prevent_Knee_Osteoarthritis.pdfTest
http://www.scopus.com/inward/record.url?scp=85179044965&partnerID=8YFLogxKTest

المؤلفون: McDermott, Gregory C., Monshadizeh, Armaan, Selzer, Faith, Zhao, Sizheng S., Ermann, Joerg, Katz, Jeffrey N.

المصدر: McDermott , G C , Monshadizeh , A , Selzer , F , Zhao , S S , Ermann , J & Katz , J N 2024 , ' Factors associated with diagnostic delay in axial spondyloarthritis: impact of clinical factors and social vulnerability ' , Arthritis Care & Research , vol. 76 , no. 4 , pp. 541-549 . https://doi.org/10.1002/acr.25264Test

مصطلحات موضوعية: axial spondyloarthritis, diagnostic delay, uveitis

الوصف: Objective: Axial spondyloarthritis (axSpA) patients often experience significant delay between symptom onset and diagnosis. Determinants of delay are incompletely understood. We investigated associations between demographic, medical, and socioeconomic factors and axSpA diagnostic delay. Methods: We identified axSpA patients diagnosed by rheumatologists in the Mass General Brigham health care system between December 1990 and October 2021. All patients met modified New York criteria for ankylosing spondylitis (AS) or 2009 Assessment of SpondloArthritis international Society (ASAS) criteria for axSpA. We determined the duration of diagnostic delay, defined as the duration of back pain symptoms reported at diagnosis, as well as extra-articular disease manifestations and specialty care received prior to diagnosis from the electronic health record. We obtained each patient’s social vulnerability index (SVI) by mapping their address to the US Centers for Disease Control SVI Atlas. We examined associations between disease manifestations, SVI, and diagnostic delay using ordinal logistic regression. Results: We identified 554 axSpA patients with mean diagnostic delay 6.8 (SD 8.5) years. In multivariable ordinal logistic regression analyses, peripheral arthritis (OR 0.65, 95%CI 0.45-0.93) and older age at symptom onset (OR 0.83, 95%CI 0.78-0.88 per 5 years) were associated with shorter delay. AS at diagnosis (OR 1.85, 95%CI 1.30-2.63), having a history of uveitis prior to diagnosis (OR 2.77, 95%CI 1.73-4.52), and higher social vulnerability (defined as being in the 80-99th percentile of SVI – OR 1.99, 95%CI 1.06-3.84) were associated with longer diagnostic delay. Conclusion: Older age at back pain onset and peripheral arthritis were associated with shorter delay while uveitis was associated with longer diagnostic delay. Patients with higher socioeconomic vulnerability had longer diagnostic delay independent of clinical factors.

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

العلاقة: https://research.manchester.ac.uk/en/publications/d0a4aea8-b9f2-4f29-99de-350c9741d068Test

الإتاحة: https://doi.org/10.1002/acr.25264Test
https://research.manchester.ac.uk/en/publications/d0a4aea8-b9f2-4f29-99de-350c9741d068Test
https://pure.manchester.ac.uk/ws/files/278740331/axspa_diagnostic_delay.docxTest

المؤلفون: Kwon, Youngho, Rösner, Heike, Zhao, Weixing, Selemenakis, Platon, He, Zhuoling, Kawale, Ajinkya S, Katz, Jeffrey N, Rogers, Cody M, Neal, Francisco E, Badamchi Shabestari, Aida, Petrosius, Valdemaras, Singh, Akhilesh K, Joel, Marina Z, Lu, Lucy, Holloway, Stephen P, Burma, Sandeep, Mukherjee, Bipasha, Hromas, Robert, Mazin, Alexander, Wiese, Claudia, Sørensen, Claus S., Sung, Patrick

المصدر: Kwon , Y , Rösner , H , Zhao , W , Selemenakis , P , He , Z , Kawale , A S , Katz , J N , Rogers , C M , Neal , F E , Badamchi Shabestari , A , Petrosius , V , Singh , A K , Joel , M Z , Lu , L , Holloway , S P , Burma , S , Mukherjee , B , Hromas , R , Mazin , A , Wiese , C , Sørensen , C S & Sung , P 2023 , ' ....

مصطلحات موضوعية: DNA Replication, Rad51 Recombinase/genetics, DNA Repair, BRCA2 Protein/metabolism, DNA, Homologous Recombination

الوصف: The tumor suppressor BRCA2 participates in DNA double-strand break repair by RAD51-dependent homologous recombination and protects stressed DNA replication forks from nucleolytic attack. We demonstrate that the C-terminal Recombinase Binding (CTRB) region of BRCA2, encoded by gene exon 27, harbors a DNA binding activity. CTRB alone stimulates the DNA strand exchange activity of RAD51 and permits the utilization of RPA-coated ssDNA by RAD51 for strand exchange. Moreover, CTRB functionally synergizes with the Oligonucleotide Binding fold containing DNA binding domain and BRC4 repeat of BRCA2 in RPA-RAD51 exchange on ssDNA. Importantly, we show that the DNA binding and RAD51 interaction attributes of the CTRB are crucial for homologous recombination and protection of replication forks against MRE11-mediated attrition. Our findings shed light on the role of the CTRB region in genome repair, reveal remarkable functional plasticity of BRCA2, and help explain why deletion of Brca2 exon 27 impacts upon embryonic lethality.

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1038/s41467-023-36211-xTest
https://curis.ku.dk/portal/da/publications/dna-binding-and-rad51-engagement-by-the-brca2-cterminus-orchestrate-dna-repair-and-replication-fork-preservationTest(95674b82-f17e-4821-8f1d-29a05bec874a).html
https://curis.ku.dk/ws/files/336597181/s41467_023_36211_x.pdfTest

المؤلفون: Hunter, David J, Deveza, Leticia A, Collins, Jamie E, Losina, Elena, Nevitt, Michael C, Roemer, Frank W, Guermazi, Ali, Bowes, Michael A, Dam, Erik B, Eckstein, Felix, Lynch, John A, Katz, Jeffrey N, Kwoh, C Kent, Hoffmann, Steve, Kraus, Virginia B

المصدر: Hunter , D J , Deveza , L A , Collins , J E , Losina , E , Nevitt , M C , Roemer , F W , Guermazi , A , Bowes , M A , Dam , E B , Eckstein , F , Lynch , J A , Katz , J N , Kwoh , C K , Hoffmann , S & Kraus , V B 2022 , ' Multivariable modeling of biomarker data from the phase 1 Foundation for the NIH Osteoarthritis Biomarkers Consortium ' , Arthritis Care & Research , vol. 74 , ....

مصطلحات موضوعية: envir, psy

الوصف: OBJECTIVE: To determine the optimal combination of imaging and biochemical biomarkers to predict knee osteoarthritis (OA) progression. METHODS: Nested case-control study from the FNIH OA Biomarkers Consortium of participants with Kellgren-Lawrence grade 1-3 and complete biomarker data (n=539 to 550). Cases were knees with radiographic and pain progression between 24-48 months from baseline. Radiographic progression only was assessed in secondary analyses. Biomarkers (baseline and 24-month changes) with p<0.10 in univariate analysis were selected, including MRI (quantitative (Q) cartilage thickness and volume; semi-quantitative (SQ) MRI markers; bone shape and area; Q meniscal volume), radiographic (trabecular bone texture (TBT)), and serum and/or urine biochemical markers. Multivariable logistic regression models were built using three different step-wise selection methods (complex vs. parsimonious models). RESULTS: Among baseline biomarkers, the number of locations affected by osteophytes (SQ), Q central medial femoral and central lateral femoral cartilage thickness, patellar bone shape, and SQ Hoffa-synovitis predicted progression in most models (C-statistics 0.641-0.671). 24-month changes in SQ MRI markers (effusion-synovitis, meniscal morphology, and cartilage damage), Q central medial femoral cartilage thickness, Q medial tibial cartilage volume, Q lateral patellofemoral bone area, horizontal TBT (intercept term), and urine NTX-I predicted progression in most models (C-statistics 0.680-0.724). A different combination of imaging and biochemical biomarkers (baseline and 24-month change) predicted radiographic progression only, with higher C-statistics (0.716-0.832). CONCLUSION: This study highlights the combination of biomarkers with potential prognostic utility in OA disease-modifying trials. Properly qualified, these biomarkers could be used to enrich future trials with participants likely to progress.

العلاقة: https://curis.ku.dk/portal/da/publications/multivariable-modeling-of-biomarker-data-from-the-phase-1-foundation-for-the-nih-osteoarthritis-biomarkers-consortiumTest(f355b1de-ba46-4a63-971c-1eb257fde3e6).html

الإتاحة: https://doi.org/10.1002/acr.24557Test
https://curis.ku.dk/portal/da/publications/multivariable-modeling-of-biomarker-data-from-the-phase-1-foundation-for-the-nih-osteoarthritis-biomarkers-consortiumTest(f355b1de-ba46-4a63-971c-1eb257fde3e6).html

المؤلفون: Hunter, David J, Deveza, Leticia A, Collins, Jamie E, Losina, Elena, Nevitt, Michael C, Roemer, Frank W, Guermazi, Ali, Bowes, Michael A, Dam, Erik B, Eckstein, Felix, Lynch, John A, Katz, Jeffrey N, Kwoh, C Kent, Hoffmann, Steve, Kraus, Virginia B

المصدر: Hunter , D J , Deveza , L A , Collins , J E , Losina , E , Nevitt , M C , Roemer , F W , Guermazi , A , Bowes , M A , Dam , E B , Eckstein , F , Lynch , J A , Katz , J N , Kwoh , C K , Hoffmann , S & Kraus , V B 2022 , ' Multivariable modeling of biomarker data from the phase 1 Foundation for the NIH Osteoarthritis Biomarkers Consortium ' , Arthritis Care & Research , vol. 74 , ....

الوصف: OBJECTIVE: To determine the optimal combination of imaging and biochemical biomarkers to predict knee osteoarthritis (OA) progression. METHODS: Nested case-control study from the FNIH OA Biomarkers Consortium of participants with Kellgren-Lawrence grade 1-3 and complete biomarker data (n=539 to 550). Cases were knees with radiographic and pain progression between 24-48 months from baseline. Radiographic progression only was assessed in secondary analyses. Biomarkers (baseline and 24-month changes) with p<0.10 in univariate analysis were selected, including MRI (quantitative (Q) cartilage thickness and volume; semi-quantitative (SQ) MRI markers; bone shape and area; Q meniscal volume), radiographic (trabecular bone texture (TBT)), and serum and/or urine biochemical markers. Multivariable logistic regression models were built using three different step-wise selection methods (complex vs. parsimonious models). RESULTS: Among baseline biomarkers, the number of locations affected by osteophytes (SQ), Q central medial femoral and central lateral femoral cartilage thickness, patellar bone shape, and SQ Hoffa-synovitis predicted progression in most models (C-statistics 0.641-0.671). 24-month changes in SQ MRI markers (effusion-synovitis, meniscal morphology, and cartilage damage), Q central medial femoral cartilage thickness, Q medial tibial cartilage volume, Q lateral patellofemoral bone area, horizontal TBT (intercept term), and urine NTX-I predicted progression in most models (C-statistics 0.680-0.724). A different combination of imaging and biochemical biomarkers (baseline and 24-month change) predicted radiographic progression only, with higher C-statistics (0.716-0.832). CONCLUSION: This study highlights the combination of biomarkers with potential prognostic utility in OA disease-modifying trials. Properly qualified, these biomarkers could be used to enrich future trials with participants likely to progress.

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1002/acr.24557Test
https://curis.ku.dk/portal/da/publications/multivariable-modeling-of-biomarker-data-from-the-phase-1-foundation-for-the-nih-osteoarthritis-biomarkers-consortiumTest(f355b1de-ba46-4a63-971c-1eb257fde3e6).html
https://curis.ku.dk/ws/files/357275079/Multivar.pdfTest

المؤلفون: Price, Andrew J, Alvand, Abtin, Troelsen, Anders, Katz, Jeffrey N, Hooper, Gary, Gray, Alastair, Carr, Andrew, Beard, David

المصدر: Price , A J , Alvand , A , Troelsen , A , Katz , J N , Hooper , G , Gray , A , Carr , A & Beard , D 2018 , ' Knee replacement ' , Lancet Oncology , vol. 392 , no. 10158 , pp. 1672-1682 . https://doi.org/10.1016/S0140-6736Test(18)32344-4

مصطلحات موضوعية: Arthroplasty, Replacement, Knee/adverse effects, Biomedical Technology/legislation & jurisprudence, Cost-Benefit Analysis, Humans, Knee Prosthesis, Osteoarthritis, Knee/epidemiology, Patient Reported Outcome Measures, Postoperative Complications/prevention & control, Prosthesis Design, Quality of Life, Reoperation, United Kingdom/epidemiology, United States/epidemiology

الوصف: Knee replacement surgery is one of the most commonly done and cost-effective musculoskeletal surgical procedures. The numbers of cases done continue to grow worldwide, with substantial variation in utilisation rates across regions and countries. The main indication for surgery remains painful knee osteoarthritis with reduced function and quality of life. The threshold for intervention is not well defined, and is influenced by many factors including patient and surgeon preference. Most patients have a very good clinical outcome after knee replacement, but multiple studies have reported that 20% or more of patients do not. So despite excellent long-term survivorship, more work is required to enhance this procedure and development is rightly focused on increasing the proportion of patients who have successful pain relief after surgery. Changing implant design has historically been a target for improving outcome, but there is greater recognition that improvements can be achieved by better implantation methods, avoiding complications, and improving perioperative care for patients, such as enhanced recovery programmes. New technologies are likely to advance future knee replacement care further, but their introduction must be regulated and monitored with greater rigour to ensure patient safety.

الإتاحة: https://doi.org/10.1016/S0140-6736Test(18)32344-4
https://curis.ku.dk/portal/da/publications/knee-replacementTest(1ecbc955-04f4-4804-b44f-4669be06510c).html

المؤلفون: Amick, Benjamin C, Lee, Hyunmi, Hogg-Johnson, Sheilah, Katz, Jeffrey N, Brouwer, Sandra, Franche, Renée-Louise, Bültmann, Ute

المصدر: Amick , B C , Lee , H , Hogg-Johnson , S , Katz , J N , Brouwer , S , Franche , R-L & Bültmann , U 2017 , ' How Do Organizational Policies and Practices Affect Return to Work and Work Role Functioning Following a Musculoskeletal Injury? ' , Journal of Occupational Rehabilitation , vol. 27 , no. 3 , pp. 393-404 . https://doi.org/10.1007/s10926-016-9668-8Test

مصطلحات موضوعية: Organizational policies and practices, Return-to-work, Work role functioning, Self-efficacy, Work accommodation, LOW-BACK-PAIN, DISABILITY MANAGEMENT-PRACTICES, HEALTH-CARE WORKPLACES, PREDICTIVE-VALIDITY, IMPACT, LIMITATIONS, DISORDERS, SURGERY, QUESTIONNAIRE

الوصف: Purpose Organizational-level policies and practices that promote safety leadership and practices, disability management and ergonomic policies and practices are considered key contextual determinants of return to work. Our objective was to examine the role of worker-reported organizational policies and practices (OPPs) in return to work (RTW) and work role functioning (WRF) and the mediating role of pain self-efficacy and work accommodation. Methods A worker cohort (n = 577) in Ontario, Canada was followed at 1, 6 and 12 months post injury. Both RTW (yes/no) and WRF (WLQ-16) status (3 levels) were measured. OPPs were measured (high vs. low) at 1 month post-injury. Pain self-efficacy (PSE) and work accommodation (WA) were included in mediation analyses. Results OPPs predicted RTW at 6 months (adjusted OR 1.77; 95 % CI 1.07-2.93) and 12 months (adjusted OR 2.07; 95 % CI 1.18-3.62). OPPs predicted WRF at 6 months, but only the transition from working with limitations to working without limitations (adjusted OR 3.21; 95 % CI 1.92-5.39). At 12 months, OPPs predicted both the transition from not working to working with and without limitations and from not working or working with limitations to working without limitations (adjusted OR 2.13; 95 % CI 1.37-3.30). Offers of WA mediated the relationship between OPPs and both RTW and WRF at 6 months follow-up. PSE mediated the relationship between OPPs and RTW and WRF at 6 months. At 12 months neither mediated the relationship. Conclusions The findings support worker-reported OPPs as key determinants of both RTW and WRF. These results point to the importance of WA and PSE in both RTW and WRF at 6 months.

العلاقة: https://research.rug.nl/en/publications/b72c22ed-2ac3-456d-ae67-6fc14dc4a422Test

الإتاحة: https://doi.org/10.1007/s10926-016-9668-8Test
https://hdl.handle.net/11370/b72c22ed-2ac3-456d-ae67-6fc14dc4a422Test
https://research.rug.nl/en/publications/b72c22ed-2ac3-456d-ae67-6fc14dc4a422Test

المؤلفون: Niu, Jingbo, Nevitt, Michael, McCulloch, Charles, Torner, James, Lewis, C. Elizabeth, Katz, Jeffrey N., Felson, David T.

المصدر: Niu , J , Nevitt , M , McCulloch , C , Torner , J , Lewis , C E , Katz , J N & Felson , D T 2014 , ' Comparing the functional impact of knee replacements in two cohorts ' , BMC Musculoskeletal Disorders , vol. 15 , no. 1 , 145 . https://doi.org/10.1186/1471-2474-15-145Test

مصطلحات موضوعية: Epidemiology, Function, Total knee replacement

الوصف: Background: To examine if different rates of total knee replacement (TKR) in two similar cohorts with symptomatic knee osteoarthritis (OA) were associated with different functional impact of disease. Methods. Subjects from the Multicenter Osteoarthritis Study (MOST) and the Osteoarthritis Initiative (OAI), persons with or at high risk of OA, had knee radiographs, completed Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) surveys and had TKRs confirmed at each visit. At each visit, subjects were defined as having symptomatic OA (SxOA) if ≥ one knee had pain and radiographic OA or if they had a TKR. WOMAC function scores at each visit were compared by analysis of covariance adjusting for age, sex, body mass index, race, site, depression, comorbidity, painful leg joints and knees affected. Post-TKR function scores were imputed to estimate scores that would have been present without TKR. Results: Subjects with SxOA (n > 750 in MOST and in OAI) had a mean age 66 to 67 years; most were women and were White. Subjects were followed 4-5 years. Among those with SxOA, more TKRs were done in MOST (35%) than OAI (19%). Adjusted mean WOMAC function (0-68, 68 = worst) improved from 26.9 to 21.9 in MOST and from 24.5 to 22.0 in OAI (difference between MOST and OAI in change in WOMAC function, p =.01). Estimates of function without TKRs showed function would not have changed in MOST (23.2 at baseline to 22.4). Conclusions: Functional status of subjects with knee OA in MOST improved more than in OAI, probably because of higher rates of TKRs. The decline suggests that TKR diminishes the functional impact of OA in the community. © 2014 Niu et al.; licensee BioMed Central Ltd.

الإتاحة: https://doi.org/10.1186/1471-2474-15-145Test
https://research.manchester.ac.uk/en/publications/7224b9b0-14f5-45bf-af96-d3c33d4c4c9cTest

المؤلفون: Gossec, Laure, Paternotte, Simon, Bingham, Clifton O, Clegg, Daniel O, Coste, Philippe, Conaghan, Philip G, Davis, Aileen M, Giacovelli, Giampaolo, Gunther, Klaus-Peter, Hawker, Gillian, Hochberg, Marc C, Jordan, Joanne M, Katz, Jeffrey N, Kloppenburg, Margreet, Lanzarotti, Arturo, Lim, Keith, Lohmander, L Stefan, Mahomed, Nizar N, Maillefert, Jean Francis, Manno, Rebecca L, March, Lyn M, Mazzuca, Steven A, Pavelka, Karel, Punzi, Leonardo, Roos, Ewa M., Rovati, Lucio C, Shi, Helen, Singh, Jasvinder A, Suarez-Almazor, Maria E, Tajana-Messi, Eleonora, Dougados, Maxime

المصدر: Gossec , L , Paternotte , S , Bingham , C O , Clegg , D O , Coste , P , Conaghan , P G , Davis , A M , Giacovelli , G , Gunther , K-P , Hawker , G , Hochberg , M C , Jordan , J M , Katz , J N , Kloppenburg , M , Lanzarotti , A , Lim , K , Lohmander , L S , Mahomed , N N , Maillefert , J F , Manno , R L , March , L M , Mazzuca , S ....

الوصف: To define pain and physical function cutpoints that would, coupled with structural severity, define a surrogate measure of "need for joint replacement surgery," for use as an outcome measure for potential structure-modifying interventions for osteoarthritis (OA).

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/3403bd42-635a-4c23-a756-162f17961a7dTest

الإتاحة: https://doi.org/10.3899/jrheum.110403Test
https://portal.findresearcher.sdu.dk/da/publications/3403bd42-635a-4c23-a756-162f17961a7dTest

المؤلفون: Gossec, Laure, Hawker, Gillian, Davis, Aileen M, Maillefert, Jean Francis, Lohmander, L Stefan, Altman, Roy, Cibere, Jolanda, Conaghan, Philip G, Hochberg, Marc C, Jordan, Joanne M, Katz, Jeffrey N, March, Lyn, Mahomed, Nizar, Pavelka, Karel, Roos, Ewa, Suarez-Almazor, Maria E, Zanoli, Gustavo, Dougados, Maxime

المصدر: Gossec , L , Hawker , G , Davis , A M , Maillefert , J F , Lohmander , L S , Altman , R , Cibere , J , Conaghan , P G , Hochberg , M C , Jordan , J M , Katz , J N , March , L , Mahomed , N , Pavelka , K , Roos , E , Suarez-Almazor , M E , Zanoli , G & Dougados , M 2007 , ' OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis ....

مصطلحات موضوعية: Arthroplasty, Replacement, Hip, Knee, Disability Evaluation, Disease Progression, Focus Groups, Humans, International Cooperation, Interviews as Topic, Osteoarthritis, Outcome Assessment (Health Care), Pain Measurement, Reproducibility of Results, Severity of Illness Index

الوصف: Udgivelsesdato: 2007-Jun ; OBJECTIVE: Time to theoretical indication of joint replacement surgery has been proposed as a primary outcome for potential structure-modifying interventions for osteoarthritis (OA). The objectives of this OMERACT/OARSI Working Group were to identify pain, physical function, and structure states that represent the progression from early to late disease for individuals with OA of the hip and knee, and to create a composite measure of these 3 domains to define states of OA severity and a surrogate measure of "need for joint replacement surgery." METHODS: For pain, focus groups and one-on-one interviews were used. For function, Rasch analysis was performed on existing indices the Hip Dysfunction and Osteoarthritis Outcome Score (HOOS) and the Knee injury and Osteoarthritis Outcome Score (KOOS), each of which subsumes the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) questions. For structure, a comparison of existing indices (Kellgren-Lawrence, OARSI stages, and joint space width) was performed for the hip and the knee. RESULTS: For pain, key features of pain that are most distressing to people with OA from early to late disease were identified. For function, the reduction of the number of items based on the existing indices continues. For structure, the analysis is also ongoing. CONCLUSION: Preliminary results were presented at OMERACT 8; the final objective will be to combine the 3 domains (pain, function, and structure) and to create a composite index that could define states of severity and "need for total joint replacement," which could be used to evaluate treatment response to disease-modifying drugs in OA clinical trials.

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/97b144c0-e30d-11dd-990c-000ea68e967bTest

الإتاحة: https://portal.findresearcher.sdu.dk/da/publications/97b144c0-e30d-11dd-990c-000ea68e967bTest