دورية أكاديمية
The microbiological diagnosis of tuberculous meningitis:results of Haydarpasa-1 study
| العنوان: | The microbiological diagnosis of tuberculous meningitis:results of Haydarpasa-1 study |
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| المؤلفون: | Erdem, H, Ozturk-Engin, D, Elaldi, N, Gulsun, S, Sengoz, G, Crisan, A, Johansen, Isik Somuncu, Inan, A, Nechifor, M, Al-Mahdawi, A, Civljak, R, Ozguler, M, Savic, B, Ceran, N, Cacopardo, B, Inal, A S, Namiduru, M, Dayan, S, Kayabas, U, Parlak, E, Khalifa, A, Kursun, E, Sipahi, O R, Yemisen, M, Akbulut, A, Bitirgen, M, Dulovic, O, Kandemir, B, Luca, C, Parlak, M, Stahl, J P, Pehlivanoglu, F, Simeon, S, Ulu-Kilic, A, Yasar, K, Yilmaz, G, Yilmaz, E, Beovic, B, Catroux, M, Lakatos, B, Sunbul, M, Oncul, O, Alabay, S, Sahin-Horasan, E, Kose, S, Shehata, G, Andre, K, Alp, A, Cosić, G, Cem Gul, H, Karakas, A, Chadapaud, S, Hansmann, Y, Harxhi, A, Kirova, V, Masse-Chabredier, I, Oncu, S, Sener, A, Tekin, R, Deveci, O, Karabay, O, Agalar, C |
| المصدر: | Erdem , H , Ozturk-Engin , D , Elaldi , N , Gulsun , S , Sengoz , G , Crisan , A , Johansen , I S , Inan , A , Nechifor , M , Al-Mahdawi , A , Civljak , R , Ozguler , M , Savic , B , Ceran , N , Cacopardo , B , Inal , A S , Namiduru , M , Dayan , S , Kayabas , U , Parlak , E , Khalifa , A , Kursun , E , Sipahi , O R , Yemisen , M , .... |
| سنة النشر: | 2014 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | Culture, Diagnosis, Meningitis, PCR, Tuberculosis |
| الوصف: | We aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa-1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich-Ziehl-Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon-γ release assay (Quantiferon TB gold in tube) 90.2%, automated culture systems (ACS) 81.8%, Löwenstein Jensen medium (L-J) 72.7%, adenosine deaminase (ADA) 29.9% and EZNs 27.3%. CSF-ACS was superior to CSF L-J culture and CSF-PCR (p <0.05 for both). Accordingly, CSF L-J culture was superior to CSF-PCR (p <0.05). Combination of L-J and ACS was superior to using these tests alone (p <0.05). There were poor and inverse agreements between EZNs and L-J culture (κ = -0.189); ACS and L-J culture (κ = -0.172) (p <0.05 for both). Fair and inverse agreement was detected for CSF-ADA and CSF-PCR (κ = -0.299, p <0.05). Diagnostic accuracy of TBM was increased when both ACS and L-J cultures were used together. Non-culture tests contributed to TBM diagnosis to a degree. However, due to the delays in the diagnosis with any of the cultures, combined use of non-culture tests appears to contribute early diagnosis. Hence, the diagnostic approach to TBM should be individualized according to the technical capacities of medical institutions particularly in those with poor resources. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://portal.findresearcher.sdu.dk/da/publications/b757a475-1f16-4336-8a25-6ec569ba5c10Test |
| DOI: | 10.1111/1469-0691.12478 |
| الإتاحة: | https://doi.org/10.1111/1469-0691.12478Test https://portal.findresearcher.sdu.dk/da/publications/b757a475-1f16-4336-8a25-6ec569ba5c10Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.373D95EC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/1469-0691.12478 |
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