دورية أكاديمية
Ribonuclease-mediated control of body fat
| العنوان: | Ribonuclease-mediated control of body fat |
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| المؤلفون: | Habacher, Cornelia, Guo, Yanwu, Venz, Richard, Kumari, Pooja, Neagu, Anca, Gaidatzis, Dimos, Harvald, Eva B, Færgeman, Nils J, Gut, Heinz, Ciosk, Rafal |
| المصدر: | Habacher , C , Guo , Y , Venz , R , Kumari , P , Neagu , A , Gaidatzis , D , Harvald , E B , Færgeman , N J , Gut , H & Ciosk , R 2016 , ' Ribonuclease-mediated control of body fat ' , Developmental Cell , vol. 39 , no. 3 , pp. 359-369 . https://doi.org/10.1016/j.devcel.2016.09.018Test |
| سنة النشر: | 2016 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| الوصف: | Obesity is a global health issue, arousing interest in molecular mechanisms controlling fat. Transcriptional regulation of fat has received much attention, and key transcription factors involved in lipid metabolism, such as SBP-1/SREBP, LPD-2/C/EBP, and MDT-15, are conserved from nematodes to mammals. However, there is a growing awareness that lipid metabolism can also be controlled by post-transcriptional mechanisms. Here, we show that the Caenorhabditis elegans RNase, REGE-1, related to MCPIP1/Zc3h12a/Regnase-1, a key regulator of mammalian innate immunity, promotes accumulation of body fat. Using exon-intron split analysis, we find that REGE-1 promotes fat by degrading the mRNA encoding ETS-4, a fat-loss-promoting transcription factor. Because ETS-4, in turn, induces rege-1 transcription, REGE-1 and ETS-4 appear to form an auto-regulatory module. We propose that this type of fat regulation may be of key importance when, if faced with an environmental change, an animal must rapidly but precisely remodel its metabolism. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://portal.findresearcher.sdu.dk/da/publications/5aa36603-b315-42b4-a620-22d3e16ffc44Test |
| DOI: | 10.1016/j.devcel.2016.09.018 |
| الإتاحة: | https://doi.org/10.1016/j.devcel.2016.09.018Test https://portal.findresearcher.sdu.dk/da/publications/5aa36603-b315-42b4-a620-22d3e16ffc44Test https://findresearcher.sdu.dk/ws/files/129523306/Ribonuclease_mediated_control_of_body_fat.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1541599D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.devcel.2016.09.018 |
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