المؤلفون: Cirillo, Nicola, Morgan, David J, Pedicillo, Maria Carmela, Celentano, Antonio, Lo Muzio, Lorenzo, McCullough, Michael J, Prime, Stephen S

المصدر: Cirillo , N , Morgan , D J , Pedicillo , M C , Celentano , A , Lo Muzio , L , McCullough , M J & Prime , S S 2017 , ' Characterisation of the cancer-associated glucocorticoid system : key role of 11β-hydroxysteroid dehydrogenase type 2 ' , British Journal of Cancer , vol. 117 , no. 7 , pp. 984-993 . https://doi.org/10.1038/bjc.2017.243Test

مصطلحات موضوعية: 11-beta-Hydroxysteroid Dehydrogenase Type 1, 11-beta-Hydroxysteroid Dehydrogenase Type 2, Adrenocorticotropic Hormone, CD8-Positive T-Lymphocytes, Carcinoma, Squamous Cell, Cell Adhesion, Cell Proliferation, Cortisone, Culture Media, Conditioned, Down-Regulation, Epithelial Cells, Gene Silencing, Glycyrrhetinic Acid, HT29 Cells, Humans, Hydrocortisone, Keratinocytes, MCF-7 Cells, Melanoma, Paracrine Communication, Receptors, Glucocorticoid, Skin Neoplasms, Journal Article

وصف الملف: application/pdf

العلاقة: https://research-information.bris.ac.uk/en/publications/68381e00-4bc4-4b46-955e-64c35ba40c62Test

الإتاحة: https://doi.org/10.1038/bjc.2017.243Test
https://hdl.handle.net/1983/68381e00-4bc4-4b46-955e-64c35ba40c62Test
https://research-information.bris.ac.uk/en/publications/68381e00-4bc4-4b46-955e-64c35ba40c62Test
https://research-information.bris.ac.uk/ws/files/135847643/BJC_REV1_final.pdfTest
https://research-information.bris.ac.uk/ws/files/135847642/bjc2017243.pdfTest

المؤلفون: Harno, Erika, Cottrell, Elizabeth C., Keevil, Brian G., DeSchoolmeester, Joanne, Bohlooly-Y, Mohammad, Andersén, Harriet, Turnbull, Andrew V., Leighton, Brendan, White, Anne

المصدر: Harno , E , Cottrell , E C , Keevil , B G , DeSchoolmeester , J , Bohlooly-Y , M , Andersén , H , Turnbull , A V , Leighton , B & White , A 2013 , ' 11-dehydrocorticosterone causes metabolic syndrome, which is prevented when 11β-HSD1 is knocked out in livers of male mice ' , Endocrinology , vol. 154 , no. 10 , pp. 3599-3609 . https://doi.org/10.1210/en.2013-1362Test

مصطلحات موضوعية: 11-beta-Hydroxysteroid Dehydrogenase Type 1, Adiposity, Animals, Biomarkers, Corticosterone, Down-Regulation, Glucocorticoids, Hyperinsulinism, Hyperphagia, Hypothalamo-Hypophyseal System, Insulin Resistance, Liver, Male, Metabolic Syndrome X, Mice, Inbred C57BL, Knockout, Pituitary-Adrenal System, Weight Gain

الإتاحة: https://doi.org/10.1210/en.2013-1362Test
https://research.manchester.ac.uk/en/publications/2f1c2af6-e439-4d80-827b-eeeb79b83b60Test
http://www.scopus.com/inward/record.url?eid=2-s2.0-84884693007&partnerID=MN8TOARSTest

المؤلفون: Yuen, Kevin C J, Roberts, Charles T, Frystyk, Jan, Rooney, William D, Pollaro, James R, Klopfenstein, Bethany J, Purnell, Jonathan Q

المصدر: Yuen , K C J , Roberts , C T , Frystyk , J , Rooney , W D , Pollaro , J R , Klopfenstein , B J & Purnell , J Q 2014 , ' Short-term, low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency ' , Journal of Clinical Endocrinology and Metabolism , vol. 99 , no. 10 , pp. E1862-9 . https://doi.org/10.1210/jc.2014-1532Test

مصطلحات موضوعية: 11-beta-Hydroxysteroid Dehydrogenase Type 1, Adipocytes, Adipose Tissue, Adult, Anthropometry, Blood Glucose, C-Peptide, Double-Blind Method, Female, Glucose Clamp Technique, Growth Disorders, Human Growth Hormone, Humans, Hydrocortisone, Insulin Resistance, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Male

الإتاحة: https://doi.org/10.1210/jc.2014-1532Test
https://pure.au.dk/portal/da/publications/shortterm-lowdose-gh-therapy-improves-insulin-sensitivity-without-modifying-cortisol-metabolism-and-ectopic-fat-accumulation-in-adults-with-gh-deficiencyTest(ac14be6f-bf08-4c2e-84d9-925afa056216).html

المؤلفون: Harno, E., Cottrell, E.C., Yu, A., DeSchoolmeester, J., Gutierrez, P.M., Denn, M., Swales, J.G., Goldberg, F.W., Bohlooly-Y, M., Andersén, H., Wild, M.J., Turnbull, A.V., Leighton, B., White, A.

المصدر: Harno , E , Cottrell , E C , Yu , A , DeSchoolmeester , J , Gutierrez , P M , Denn , M , Swales , J G , Goldberg , F W , Bohlooly-Y , M , Andersén , H , Wild , M J , Turnbull , A V , Leighton , B & White , A 2013 , ' 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors still improve metabolic phenotype in male 11β-HSD1 knockout mice suggesting off-target mechanisms ' , Endocrinology , vol. 154 , no. 12 , pp. 4580-4593 . https://doi.org/10.1210/en.2013-1613Test

مصطلحات موضوعية: 11-beta-Hydroxysteroid Dehydrogenase Type 1, Adipose Tissue, Animals, Blood Glucose, Body Weight, Brain, Dietary Fats, Dose-Response Relationship, Drug, Energy Metabolism, Female, Gene Expression Regulation, Enzymologic, Genotype, Glucose, Hypoglycemic Agents, Insulin, Liver, Male, Mice, Knockout, Molecular Structure, Pyrazoles, Pyrimidines, RNA, Messenger, Triazoles

الإتاحة: https://doi.org/10.1210/en.2013-1613Test
https://research.manchester.ac.uk/en/publications/477b10a0-ea81-433d-a5e9-163ebe03deb5Test
http://www.scopus.com/inward/record.url?eid=2-s2.0-84888262119&partnerID=MN8TOARSTest

المؤلفون: Harno, E., White, A.

المصدر: Harno , E & White , A 2010 , ' Will treating diabetes with 11β-HSD1 inhibitors affect the HPA axis? ' , Trends in Endocrinology and Metabolism , vol. 21 , no. 10 , pp. 619-627 . https://doi.org/10.1016/j.tem.2010.06.004Test

مصطلحات موضوعية: 11-beta-Hydroxysteroid Dehydrogenase Type 1, Aminopyridines, Animals, Diabetes Mellitus, Type 2, Hydrocortisone, Hypoglycemic Agents, Hypothalamo-Hypophyseal System, Mice, Knockout, Transgenic, Pituitary-Adrenal System, Sulfonamides

الإتاحة: https://doi.org/10.1016/j.tem.2010.06.004Test
https://research.manchester.ac.uk/en/publications/c548b517-9261-4fca-94ca-242fcd928008Test
http://www.scopus.com/inward/record.url?eid=2-s2.0-77957220210&partnerID=MN8TOARSTest

المؤلفون: Paulsen, Søren Kildeberg, Pedersen, Steen Bønløkke, Fisker, Sanne, Richelsen, Bjørn

المصدر: Paulsen , S K , Pedersen , S B , Fisker , S & Richelsen , B 2007 , ' 11Beta-HSD type 1 expression in human adipose tissue: impact of gender, obesity, and fat localization. ' , Obesity , vol. 15 , no. 8 , pp. 1954-60 .

مصطلحات موضوعية: 11-beta-Hydroxysteroid Dehydrogenase Type 1, Adult, Cross-Sectional Studies, F Factor, Female, Gene Expression Regulation, Enzymologic, Humans, Intra-Abdominal Fat, Male, Middle Aged, Obesity, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction, Subcutaneous Fat

الإتاحة: https://pure.au.dk/portal/da/publications/11betahsdTest-type-1-expression-in-human-adipose-tissue-impact-of-gender-obesity-and-fat-localization(f977fdd0-cfd0-11dc-abe4-000ea68e967b).html

المؤلفون: Koska, Juraj, de Courten, Barbora, Wake, Deborah J, Nair, Saraswathy, Walker, Brian R, Bunt, Joy C, Permana, Paska A, Lindsay, Robert S, Tataranni, P Antonio

المصدر: Koska , J , de Courten , B , Wake , D J , Nair , S , Walker , B R , Bunt , J C , Permana , P A , Lindsay , R S & Tataranni , P A 2006 , ' 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue and prospective changes in body weight and insulin resistance ' , Obesity , vol. 14 , no. 9 , pp. 1515-22 . https://doi.org/10.1038/oby.2006.175Test

مصطلحات موضوعية: 11-beta-Hydroxysteroid Dehydrogenase Type 1, Adipocytes, Adolescent, Adult, Body Weight, Female, Humans, Indians, North American, Insulin Resistance, Male, Middle Aged, Prospective Studies, RNA, Messenger, Subcutaneous Fat, Abdominal

الإتاحة: https://doi.org/10.1038/oby.2006.175Test
https://curis.ku.dk/portal/da/publications/11betahydroxysteroidTest-dehydrogenase-type-1-in-adipose-tissue-and-prospective-changes-in-body-weight-and-insulin-resistance(df23e57b-53cf-4f49-bf2a-5866d0a9fd04).html

المؤلفون: Justesen, Jeannette, Mosekilde, Lis, Holmes, Megan, Stenderup, Karin, Gasser, Jürg, Mullins, John J, Seckl, Jonathan R, Kassem, Moustapha

المصدر: Justesen , J , Mosekilde , L , Holmes , M , Stenderup , K , Gasser , J , Mullins , J J , Seckl , J R & Kassem , M 2004 , ' Mice deficient in 11beta-hydroxysteroid dehydrogenase type 1 lack bone marrow adipocytes, but maintain normal bone formation ' , Endocrinology , vol. 145 , no. 4 , pp. 1916-25 . https://doi.org/10.1210/en.2003-1427Test

مصطلحات موضوعية: 11-beta-Hydroxysteroid Dehydrogenase Type 1, Adipocytes, Aging, Animals, Body Constitution, Body Weight, Bone Density, Bone Marrow, Bone and Bones, Cell Differentiation, Cell Division, Cells, Cultured, Mice, Knockout, Organ Size, Osteoblasts, Osteogenesis, Phenotype, Sex Characteristics

الإتاحة: https://doi.org/10.1210/en.2003-1427Test
https://pure.au.dk/portal/da/publications/mice-deficient-in-11betahydroxysteroidTest-dehydrogenase-type-1-lack-bone-marrow-adipocytes-but-maintain-normal-bone-formation(01204cd6-6dc8-4ea3-b659-73e44fc075c0).html

المؤلفون: Justesen, Jeannette, Mosekilde, Lis, Holmes, Megan, Dokkedahl, Karin Stenderup, Gasser, Jürg, Mullins, John J, Seckl, Jonathan R, Kassem, Moustapha

المصدر: Justesen , J , Mosekilde , L , Holmes , M , Dokkedahl , K S , Gasser , J , Mullins , J J , Seckl , J R & Kassem , M 2004 , ' Mice deficient in 11beta-hydroxysteroid dehydrogenase type 1 lack bone marrow adipocytes, but maintain normal bone formation ' , Endocrinology , vol. 145 , no. 4 , pp. 1916-25 . https://doi.org/10.1210/en.2003-1427Test

مصطلحات موضوعية: 11-beta-Hydroxysteroid Dehydrogenase Type 1, Adipocytes, Aging, Animals, Body Constitution, Body Weight, Bone Density, Bone Marrow, Bone and Bones, Cell Differentiation, Cell Division, Cells, Cultured, Mice, Knockout, Organ Size, Osteoblasts, Osteogenesis, Phenotype, Sex Characteristics

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/f8ae0500-eced-11db-821c-000ea68e967bTest

الإتاحة: https://doi.org/10.1210/en.2003-1427Test
https://portal.findresearcher.sdu.dk/da/publications/f8ae0500-eced-11db-821c-000ea68e967bTest