دورية أكاديمية
Effectiveness of third-class biologic treatment in crohn’s disease:A multi-center retrospective cohort study
| العنوان: | Effectiveness of third-class biologic treatment in crohn’s disease:A multi-center retrospective cohort study |
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| المؤلفون: | Albshesh, Ahmad, Taylor, Joshua, Savarino, Edoardo V., Truyens, Marie, Armuzzi, Alessandro, Ribaldone, Davide G., Shitrit, Ariella Bar Gil, Fibelman, Morine, Molander, Pauliina, Liefferinckx, Claire, Nancey, Stephane, Korani, Mohamed, Rutka, Mariann, Acosta, Manuel Barreiro De, Domislovic, Viktor, Suris, Gerard, Eriksson, Carl, Alves, Catarina, Mpitouli, Afroditi, Di Jiang, Caroline, Tepeš, Katja, Coletta, Marina, Foteinogiannopoulou, Kalliopi, Gisbert, Javier P., Amir-Barak, Hadar, Attauabi, Mohamed, Seidelin, Jakob, Afif, Waqqas, Marinelli, Carla, Lobaton, Triana, Pugliese, Daniela, Maharshak, Nitsan, Cremer, Anneline, Limdi, Jimmy K., Molnár, Tamás, Otero-Alvarin, Borja, Krznaric, Zeljko, Magro, Fernando, Karmiris, Konstantinos, Raine, Tim, Drobne, David, Koutroubakis, Ioannis, Chaparro, Maria, Yanai, Henit, Burisch, Johan, Kopylov, Uri |
| المصدر: | Albshesh , A , Taylor , J , Savarino , E V , Truyens , M , Armuzzi , A , Ribaldone , D G , Shitrit , A B G , Fibelman , M , Molander , P , Liefferinckx , C , Nancey , S , Korani , M , Rutka , M , Acosta , M B D , Domislovic , V , Suris , G , Eriksson , C , Alves , C , Mpitouli , A , Di Jiang , C , Tepeš , K , Coletta , M , Foteinogiannopoulou , K , .... |
| سنة النشر: | 2021 |
| المجموعة: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| مصطلحات موضوعية: | Anti-TNF failure, Crohn’s disease, Treatment failure, Treatment response, Ustekinumab, Vedolizumab |
| الوصف: | Background: Multiple studies have described the effectiveness of ustekinumab (UST) and vedolizumab (VDZ) in patients with Crohn’s disease (CD) failing anti-Tumor necrosis factors (TNFs); however, the effectiveness of VDZ or UST as a third-class biologic has not yet been described. Aims and Methods: In this retrospective multicenter cohort study, we aimed to investigate the effectiveness of VDZ and UST as a third-class biologic in patients with CD. Results: Two-hundred and four patients were included; 156/204 (76%) patients received VDZ as a second-and UST as a third-class therapy (group A); the remaining 48/204 (24%) patients received UST as a second-and VDZ as a third-class therapy (group B). At week 16–22, 87/156 (55.5%) patients and 27/48 (56.2%) in groups A and B, respectively, responded to treatment (p = 0.9); 41/156 (26.2%) and 15/48 (31.2%) were in clinical remission (p = 0.5). At week 52; 89/103 (86%) patients and 25/29 (86.2%) of the patients with available data had responded to third-class treatment in groups A and B, respectively (p = 0.9); 31/103 (30%) and 47/29 (24.1%) were in clinical remission (p = 0.5). Conclusion: Third-class biological therapy was effective in more than half of the patients with CD. No differences in effectiveness were detected between the use of VDZ and UST as a third-class agent. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.3390/jcm10132914 |
| الإتاحة: | https://doi.org/10.3390/jcm10132914Test https://curis.ku.dk/portal/da/publications/effectiveness-of-thirdclass-biologic-treatment-in-crohns-diseaseTest(a13a154b-1102-4bcd-9962-fdc450599d05).html https://curis.ku.dk/ws/files/280568181/jcm_10_02914_v3.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D2D05251 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/jcm10132914 |
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