دورية أكاديمية
Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT
| العنوان: | Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT |
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| المؤلفون: | Mallucci, C.L., Jenkinson, Michael, Conroy, Elizabeth J., Hartley, John C., Brown, Michaela, Moitt, Tracey, Dalton, Joanne, Kearns, Tom, Griffiths, Michael J., Culeddu, Giovanna, Solomon, Tom, Hughes, Dyfrig, Gamble, Carrol |
| المصدر: | Mallucci , C L , Jenkinson , M , Conroy , E J , Hartley , J C , Brown , M , Moitt , T , Dalton , J , Kearns , T , Griffiths , M J , Culeddu , G , Solomon , T , Hughes , D & Gamble , C 2020 , ' Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT ' , Health Technology Assessment , vol. 24 , no. 17 . https://doi.org/10.3310/hta24170Test |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | socio, edu |
| الوصف: | BACKGROUND: Insertion of a ventriculoperitoneal shunt to treat hydrocephalus is one of the most common neurosurgical procedures worldwide. Shunt infection affects up to 15% of patients, resulting in long hospital stays, multiple surgeries and reduced cognition and quality of life. OBJECTIVES: The aim of this trial was to determine whether or not antibiotic-impregnated ventriculoperitoneal shunts (hereafter referred to as antibiotic shunts) (e.g. impregnated with rifampicin and clindamycin) or silver-impregnated ventriculoperitoneal shunts (hereafter referred to as silver shunts) reduce infection compared with standard ventriculoperitoneal shunts (hereafter referred to as standard shunts). DESIGN: This was a three-arm, superiority, multicentre, parallel-group randomised controlled trial. Patients and a central primary outcome review panel, but not surgeons or operating staff, were blinded to the type of ventriculoperitoneal shunt inserted. SETTING: The trial was set in 21 neurosurgical wards across the UK and the Republic of Ireland. PARTICIPANTS: Participants were patients with hydrocephalus of any aetiology who were undergoing insertion of their first ventriculoperitoneal shunt. INTERVENTIONS: Participants were allocated 1 : 1 : 1 by pressure-sealed envelope to receive a standard non-impregnated, silver-impregnated or antibiotic-impregnated ventriculoperitoneal shunt at the time of insertion. Ventriculoperitoneal shunts are medical devices, and were used in accordance with the manufacturer's instructions for their intended purpose. MAIN OUTCOME MEASURES: The primary outcome was time to ventriculoperitoneal shunt failure due to infection. Secondary outcomes were time to failure for any cause, reason for failure (infection, mechanical), types of ventriculoperitoneal shunt infection, rate of infection after first clean (non-infected) revision and health economics. Outcomes were analysed by intention to treat. RESULTS: Between 26 June 2013 and 9 October 2017, 1605 patients from neonate to 91 years of age were ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.bangor.ac.uk/ws/files/28648389/2020_Silver_impregnated.pdfTest; https://research.bangor.ac.uk/portal/en/researchoutputs/silverimpregnated-antibioticimpregnated-or-nonimpregnated-ventriculoperitoneal-shunts-to-prevent-shunt-infection-the-basics-threearm-rctTest(89716c95-dea5-4bcd-bee0-651f72c84126).html |
| الإتاحة: | https://doi.org/10.3310/hta24170Test https://research.bangor.ac.uk/ws/files/28648389/2020_Silver_impregnated.pdfTest https://research.bangor.ac.uk/portal/en/researchoutputs/silverimpregnated-antibioticimpregnated-or-nonimpregnated-ventriculoperitoneal-shunts-to-prevent-shunt-infection-the-basics-threearm-rctTest(89716c95-dea5-4bcd-bee0-651f72c84126).html |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.AC6A1921 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |