دورية أكاديمية
Molecular Pathology of Tumors of the Central Nervous System
| العنوان: | Molecular Pathology of Tumors of the Central Nervous System |
|---|---|
| المؤلفون: | Kristensen, B W, Priesterbach-Ackley, L P, Petersen, J K, Wesseling, P |
| المصدر: | Kristensen , B W , Priesterbach-Ackley , L P , Petersen , J K & Wesseling , P 2019 , ' Molecular Pathology of Tumors of the Central Nervous System ' , Annals of Oncology , vol. 30 , no. 8 , pp. 1265-1278 . https://doi.org/10.1093/annonc/mdz164Test |
| سنة النشر: | 2019 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | CNS tumor, embryonal tumor, glioma, integrated diagnosis, medulloblastoma, molecular pathology, Immunohistochemistry, Prognosis, Humans, Survival Rate, Treatment Outcome, Gene Expression Regulation, Neoplastic/drug effects, Neoplasms, Germ Cell and Embryonal/diagnosis, Glioma/diagnosis, Antineoplastic Combined Chemotherapy Protocols/pharmacology, Brain/pathology, DNA Methylation, Biomarkers, Tumor/analysis, Drug Resistance, Neoplasm/genetics, Molecular Targeted Therapy/methods, Mutation, Brain Neoplasms/diagnosis |
| الوصف: | Since the update of the 4th edition of the WHO Classification of Central Nervous System (CNS) Tumors published in 2016, particular molecular characteristics are part of the definition of a subset of these neoplasms. This combined 'histo-molecular' approach allows for a much more precise diagnosis of especially diffuse gliomas and embryonal CNS tumors. This review provides an update of the most important diagnostic and prognostic markers for state-of-the-art diagnosis of primary CNS tumors. Defining molecular markers for diffuse gliomas are IDH1/IDH2 mutations, 1p/19q codeletion and mutations in histone H3 genes. Medulloblastomas, the most frequent embryonal CNS tumors, are divided into four molecularly defined groups according to the WHO 2016 Classification: wingless/integrated (WNT) signaling pathway activated, sonic hedgehog (SHH) signaling pathway activated and tumor protein p53 gene (TP53)-mutant, SHH-activated and TP53-wildtype, and non-WNT/non-SHH-activated. Molecular characteristics are also important for the diagnosis of several other CNS tumors, such as RELA fusion-positive subtype of ependymoma, atypical teratoid rhabdoid tumor (AT/RT), embryonal tumor with multilayered rosettes, and solitary fibrous tumor/hemangiopericytoma. Immunohistochemistry is a helpful alternative for further molecular characterization of several of these tumors. Additionally, genome-wide methylation profiling is a very promising new tool in CNS tumor diagnostics. Much progress has thus been made by translating the most relevant molecular knowledge into a more precise clinical diagnosis of CNS tumors. Hopefully, this will enable more specific and more effective therapeutic approaches for the patients suffering from these tumors. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://portal.findresearcher.sdu.dk/da/publications/21409ab1-f783-45ae-b636-e8b6b3d16687Test |
| DOI: | 10.1093/annonc/mdz164 |
| الإتاحة: | https://doi.org/10.1093/annonc/mdz164Test https://portal.findresearcher.sdu.dk/da/publications/21409ab1-f783-45ae-b636-e8b6b3d16687Test https://findresearcher.sdu.dk/ws/files/153576416/mdz164.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F8D33F26 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/annonc/mdz164 |
|---|