دورية أكاديمية
The V16A polymorphism in SOD2 is associated with increased risk of diabetic nephropathy and cardiovascular disease in type 1 diabetes
| العنوان: | The V16A polymorphism in SOD2 is associated with increased risk of diabetic nephropathy and cardiovascular disease in type 1 diabetes |
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| المؤلفون: | Möllsten, A, Jorsal, Anders, Lajer, Maria Stenkil, Vionnet, N, Tarnow, L |
| المصدر: | Möllsten , A , Jorsal , A , Lajer , M S , Vionnet , N & Tarnow , L 2009 , ' The V16A polymorphism in SOD2 is associated with increased risk of diabetic nephropathy and cardiovascular disease in type 1 diabetes ' , Diabetologia , vol. 52 , no. 12 , pp. 2590-3 . https://doi.org/10.1007/s00125-009-1550-1Test |
| سنة النشر: | 2009 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | Adult, Albuminuria, Blood Pressure, Cardiovascular Diseases, Coronary Artery Bypass, Diabetes Complications, Diabetes Mellitus, Type 1, Diabetic Angiopathies, Diabetic Nephropathies, Follow-Up Studies, Hemoglobin A, Glycosylated, Humans, Kidney Failure, Chronic, Middle Aged, Myocardial Infarction, Polymorphism, Single Nucleotide, Risk Factors, Stroke, Superoxide Dismutase |
| الوصف: | Hyperglycaemia increases oxidative stress and may thereby increase the risk of diabetic complications, including diabetic nephropathy. Cells are protected from oxidative damage by, for example, the manganese superoxide dismutase enzyme (MnSOD), but the functional polymorphism V16A affects the localisation of MnSOD and therefore its ability to scavenge superoxide radicals. In a Danish cohort of type 1 diabetes patients, we sought to confirm previous findings of association between the V allele and the risk of diabetic nephropathy and to investigate the influence of this polymorphism on the development of cardiovascular disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://pure.au.dk/portal/da/publications/the-v16a-polymorphism-in-sod2-is-associated-with-increased-risk-of-diabetic-nephropathy-and-cardiovascular-disease-in-type-1-diabetesTest(ec816339-3492-4c38-bfd8-e8dc7a4645ca).html |
| DOI: | 10.1007/s00125-009-1550-1 |
| الإتاحة: | https://doi.org/10.1007/s00125-009-1550-1Test https://pure.au.dk/portal/da/publications/the-v16a-polymorphism-in-sod2-is-associated-with-increased-risk-of-diabetic-nephropathy-and-cardiovascular-disease-in-type-1-diabetesTest(ec816339-3492-4c38-bfd8-e8dc7a4645ca).html |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.84A9DBE8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00125-009-1550-1 |
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