دورية أكاديمية
Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite
| العنوان: | Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite |
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| المؤلفون: | Lyngstad, Anna, Nymo, Siren, Coutinho, Silvia R, Rehfeld, Jens F., Truby, Helen, Kulseng, Bård, Martins, Catia |
| المصدر: | Lyngstad , A , Nymo , S , Coutinho , S R , Rehfeld , J F , Truby , H , Kulseng , B & Martins , C 2019 , ' Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite ' , The American Journal of Clinical Nutrition , vol. 109 , no. 6 , pp. 1511-1518 . https://doi.org/10.1093/ajcn/nqz002Test |
| سنة النشر: | 2019 |
| المجموعة: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| مصطلحات موضوعية: | Adolescent, Adult, Aged, Appetite, Cholecystokinin/blood, Female, Ghrelin/blood, Glucagon-Like Peptide 1/blood, Humans, Insulin/blood, Ketosis/blood, Male, Middle Aged, Obesity/blood, Peptide YY/blood, Sex Factors, Weight Loss, Young Adult |
| الوصف: | BACKGROUND: Diet-induced weight loss (WL) is usually accompanied by increased appetite, a response that seems to be absent when ketogenic diets are used. It remains unknown if sex modulates the appetite suppressant effect of ketosis. OBJECTIVE: The aim of this study was to examine if sex modulates the impact of WL-induced changes in appetite and if ketosis alters these responses. METHODS: Ninety-five individuals (55 females) with obesity (BMI [kg/m 2]: 37 ± 4) underwent 8 wk of a very-low-energy diet, followed by 4 wk of refeeding and weight stabilization. Body composition, plasma concentration of β-hydroxybutyrate (β-HB) and appetite-related hormones (active ghrelin, active glucagon-like peptide 1 [GLP-1], total peptide YY [PYY], cholecystokinin and insulin), and subjective feelings of appetite were measured at baseline, week 9 in ketosis, and week 13 out of ketosis. RESULTS: The mean WL at week 9 was 17% for males and 15% for females, which was maintained at week 13. Weight, fat, and fat-free mass loss were greater in males (P < 0.001 for all) and the increase in β-HB at week 9 higher in females (1.174 ± 0.096 compared with 0.783 ± 0.112 mmol/L, P = 0.029). Basal and postprandial GLP-1 and postprandial PYY (all P < 0.05) were significantly different for males and females. There were no significant sex × time interactions for any other appetite-related hormones or subjective feelings of appetite. At week 9, basal GLP-1 was decreased only in males (P < 0.001), whereas postprandial GLP-1 was increased only in females (P < 0.001). No significant changes in postprandial PYY were observed over time for either sex. CONCLUSIONS: Ketosis appears to have a greater beneficial impact on GLP-1 in females. However, sex does not seem to modulate the changes in the secretion of other appetite-related hormones, or subjective feelings of appetite, seen with WL, regardless of the ketotic state. This trial was registered at clinicaltrials.gov as NCT01834859. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1093/ajcn/nqz002 |
| الإتاحة: | https://doi.org/10.1093/ajcn/nqz002Test https://curis.ku.dk/portal/da/publications/investigating-the-effect-of-sex-and-ketosis-on-weightlossinduced-changes-in-appetiteTest(8be3b97f-edc2-40e0-b529-eb88414a2bbe).html https://curis.ku.dk/ws/files/237192049/nqz002.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8AC03576 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ajcn/nqz002 |
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