المؤلفون: Yu, Zhifeng, Ku, Angela F, Anglin, Justin L, Sharma, Rajesh, Ucisik, Melek Nihan, Faver, John C, Li, Feng, Nyshadham, Pranavanand, Simmons, Nicholas, Sharma, Kiran L, Nagarajan, Sureshbabu, Riehle, Kevin, Kaur, Gundeep, Sankaran, Banumathi, Storl-Desmond, Marta, Palmer, Stephen S, Young, Damian W, Kim, Choel, Matzuk, Martin M

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 118(9)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Biological Sciences, Contraception/Reproduction, Genetics, Cancer, Animals, Azepines, Binding Sites, Cell Cycle Proteins, Cloning, Molecular, Contraceptive Agents, Male, Crystallography, X-Ray, Drug Discovery, Escherichia coli, Gene Expression, Genetic Vectors, High-Throughput Screening Assays, Humans, Ligands, Male, Mice, Molecular Docking Simulation, Nuclear Proteins, Protein Binding, Protein Conformation, alpha-Helical, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, Quantitative Structure-Activity Relationship, Recombinant Proteins, Testis, Transcription Factors, Triazoles, BET bromodomains, DNA-encoded chemistry, male contraceptive, small-molecule inhibitors

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9t49g9frTest

المؤلفون: Yu, Zhifeng, Ku, Angela F, Anglin, Justin L, Sharma, Rajesh, Ucisik, Melek Nihan, Faver, John C, Li, Feng, Nyshadham, Pranavanand, Simmons, Nicholas, Sharma, Kiran L, Nagarajan, Sureshbabu, Riehle, Kevin, Kaur, Gundeep, Sankaran, Banumathi, Storl-Desmond, Marta, Palmer, Stephen S, Young, Damian W, Kim, Choel, Matzuk, Martin M

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 118(9)

مصطلحات موضوعية: Testis, Animals, Humans, Mice, Escherichia coli, Azepines, Triazoles, Contraceptive Agents, Male, Cell Cycle Proteins, Nuclear Proteins, Recombinant Proteins, Transcription Factors, Ligands, Crystallography, X-Ray, Cloning, Molecular, Gene Expression, Binding Sites, Protein Binding, Quantitative Structure-Activity Relationship, Genetic Vectors, Male, Protein Interaction Domains and Motifs, Drug Discovery, High-Throughput Screening Assays, Molecular Docking Simulation, Protein Conformation, alpha-Helical, Protein Conformation, beta-Strand, BET bromodomains, DNA-encoded chemistry, male contraceptive, small-molecule inhibitors

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9t49g9frTest

المؤلفون: Lucki, Natasha C, Villa, Genaro R, Vergani, Naja, Bollong, Michael J, Beyer, Brittney A, Lee, Jae Wook, Anglin, Justin L, Spangenberg, Stephan H, Chin, Emily N, Sharma, Amandeep, Johnson, Kevin, Sander, Philipp N, Gordon, Perry, Skirboll, Stephen L, Wurdak, Heiko, Schultz, Peter G, Mischel, Paul S, Lairson, Luke L

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 116(13)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biological Sciences, Brain Disorders, Orphan Drug, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research, Cancer, Brain Cancer, Neurosciences, Biotechnology, Rare Diseases, Stem Cell Research - Nonembryonic - Human, 5.1 Pharmaceuticals, Aetiology, 2.1 Biological and endogenous factors, Development of treatments and therapeutic interventions, Animals, Antineoplastic Agents, Apoptosis, Astrocytes, Brain Neoplasms, Cell Line, Tumor, Disease Models, Animal, Drug Delivery Systems, Drug Evaluation, Preclinical, Female, Glioblastoma, Heterografts, High-Throughput Screening Assays, Humans, MAP Kinase Kinase Kinases, Mice, Mice, Nude, Neoplastic Stem Cells, Pyroptosis, Receptor-Interacting Protein Serine-Threonine Kinase 2, Receptor-Interacting Protein Serine-Threonine Kinases, glioblastoma, phenotypic drug screening, chemical genetics, target identification, receptor-interacting protein kinase 2

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9rx5d8zhTest

المؤلفون: Lucki, Natasha C, Villa, Genaro R, Vergani, Naja, Bollong, Michael J, Beyer, Brittney A, Lee, Jae Wook, Anglin, Justin L, Spangenberg, Stephan H, Chin, Emily N, Sharma, Amandeep, Johnson, Kevin, Sander, Philipp N, Gordon, Perry, Skirboll, Stephen L, Wurdak, Heiko, Schultz, Peter G, Mischel, Paul S, Lairson, Luke L

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 116(13)

مصطلحات موضوعية: Astrocytes, Cell Line, Tumor, Animals, Humans, Mice, Mice, Nude, Glioblastoma, Brain Neoplasms, Disease Models, Animal, MAP Kinase Kinase Kinases, Antineoplastic Agents, Drug Delivery Systems, Drug Evaluation, Preclinical, Apoptosis, Female, Receptor-Interacting Protein Serine-Threonine Kinases, Neoplastic Stem Cells, High-Throughput Screening Assays, Heterografts, Pyroptosis, chemical genetics, glioblastoma, phenotypic drug screening, receptor-interacting protein kinase 2, target identification, Receptor-Interacting Protein Serine-Threonine Kinase 2, Cell Line, Tumor, Nude, Disease Models, Animal, Drug Evaluation, Preclinical

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9rx5d8zhTest