المؤلفون: Miao, Mengdan, Miao, Yifei, Zhu, Yanping, Wang, Junnan, Zhou, Huaijun

المصدر: Cancers. 14(19)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Rare Diseases, Good Health and Well Being, advances, diagnostic markers, drug delivery, exosomes, gynaecological malignancies, Oncology and carcinogenesis

الوصف: BackgroundExosomes are extracellular vesicles that can be released by practically all types of cells. They have a diameter of 30-150 nm. Exosomes control the exchange of materials and information between cells. This function is based on its special cargo-carrying and transporting functions, which can load a variety of useful components and guarantee their preservation. Recently, exosomes have been confirmed to play a significant role in the pathogenesis, diagnosis, treatment, and prognosis of gynaecological malignancies. Particularly, participation in liquid biopsy was studied extensively in gynaecological cancer, which holds the advantages of noninvasiveness and individualization.Literature reviewThis article reviews the latest research progress of exosomes in gynaecological malignancies and discusses the involvement of humoral and cell-derived exosomes in the pathogenesis, progression, metastasis, drug resistance and treatment of ovarian cancer, cervical cancer, and endometrial cancer. Advances in the clinical application of exosomes in diagnostic technology, drug delivery, and overcoming tumour resistance are also presented.ConclusionExosomes are potentially diagnostic and prognostic biomarkers in gynaecological malignancies, and also provide new directions for the treatment of gynaecological tumours, showing great clinical potential.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/03q892fjTest

المؤلفون: Wang, Yanan, Wan, Yu-Jui Yvonne

المصدر: Liver Research. 4(4)

مصطلحات موضوعية: Rare Diseases, Cancer, Liver Disease, Liver Cancer, Prevention, Digestive Diseases, Orphan Drug, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Good Health and Well Being, Alpha-fetoprotein, Diagnostic markers, Gamma-glutamyl transferase, Golgi protein 73, Hepatitis B virus, Hepatitis C virus, Hepatocellular carcinoma, Liver cancer

الوصف: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with a low survival rate. The identification of mechanisms underlying the development of HCC helps uncover cellular and molecular targets for the diagnosis, prevention, and treatment of HCC. Golgi protein 73 (GP73) level is upregulated in HCC patients and potentially can be a therapeutic target. Despite many studies devoted to GP73 as a marker for HCC early diagnosis, there is little discussion about the function of GP73 in HCC tumorigenesis. Given the poor response to currently available HCC therapies, a better understanding of the role of GP73 in HCC may provide a new therapeutic target for HCC. The current paper summarizes the role of GP73 as a diagnostic marker as well as its roles in liver carcinogenesis. Its roles in other types of cancer are also discussed.

الوصول الحر: https://escholarship.org/uc/item/1rf3392wTest