Patent
Pyridazine and pyrrole compounds, processes for obtaining them and uses
| العنوان: | Pyridazine and pyrrole compounds, processes for obtaining them and uses |
|---|---|
| Patent Number: | 9,034,873 |
| تاريخ النشر: | May 19, 2015 |
| Appl. No: | 12/309585 |
| Application Filed: | July 26, 2007 |
| مستخلص: | The present disclosure describes compounds of the following formula [chemical expression included] in which: the groups A, which may be identical or different, represent a group [chemical expression included] n is an integer equal to 1 or 2, Y represents an oxygen or sulfur atom, a methylene, hydroxymethylene, carbonyl or thiocarbonyl group, or a group of formula [chemical expression included] the groups R, which may be identical or different, represent a hydrogen, an alkyl, alkylamine, hydroxyl-alkyl or alkyloxy chain containing from 1 to 6 carbons, or a —COOH, —CONH2, —COOR2 or —CONHR2 group in which R2 is an alkyl chain containing from 1 to 6 carbons, or, when the substituents R are identical in the 2-pyridinyl groups, the substituents R2 may together form an ethereal cyclic alkyl chain, with the exception of the compounds: 2,6-di[5-(2-pyridyl)pyrrol-2-yl]pyridine and bis[5-(6-methyl-2-pyridyl)pyrrol-2-yl]methane. |
| Inventors: | Dubreuil, Didier Max (Port Saint Pere, FR); Pipelier, Muriel Genevieve (Nantes, FR); Pradere, Jean-Paul (Sautron, FR); Bakkali, Hicham (Nantes, FR); Lepape, Patrice (Vertou, FR); Delaunay, Thierry (Trevoux, FR); Tabatchnik, Alexandra (La Baule, FR) |
| Assignees: | Centre National de la Recherche Scientifique (C.N.R.S.) (Paris Cedex, FR) |
| Claim: | 1. A compound of formula [chemical expression included] in which: A is [chemical expression included] n is an integer equal to 1 or 2, Y represents an oxygen atom, a sulfur atom, a methylene group, a hydroxymethylene group, a carbonyl group, a thiocarbonyl group, [chemical expression included] the groups R, which may be identical or different, represent a hydrogen, an alkyl, alkylamine, hydroxyl-alkyl or alkyloxy chain containing from 1 to 6 carbons, or a —COOH, —CONH 2 , —COOR2 or —CONHR2 group in which R2 is an alkyl chain containing from 1 to 6 carbons, or, when the substituents R are identical in the 2-pyridinyl groups, the substituents R2 may together form an ethereal cyclic alkyl chain. |
| Claim: | 2. The compound of claim 1 wherein Y is [chemical expression included] |
| Claim: | 3. A compound selected from the group consisting of di(6-pyridin-2-yl)pyridazine ether, di(6-pyridin-2-yl)pyridazine thioether, 2,6-bis[6-(pyridin-2-yl)pyridazin-3-yl]pyridine, 2,6-bis[6-(6-methylpyridin-2-yl)pyridazin-3-yl]pyridine, 2,6-bis[3-(2-carboxypyridin-6-yl)pyridazin-6-yl]pyridine, 6,6′-bis[6-(pyridin-2-yl)pyridazin-3-yl]-2,2′-bipyridine, 2,9-bis[6-(pyridin-2-yl)pyridazin-3-yl]-1,10-phenanthroline, 2,6-bis[6-(6-methylpyridin-2-yl)pyridazin-3-yl]-2,2′-bipyridine, and 2,9-bis[6-(6-methylpyridin-2-yl)pyridazin-3-yl]-1,10-phenanthroline. |
| Current U.S. Class: | 51425/202 |
| Patent References Cited: | 2004/0186288 September 2004 Kruger et al. |
| Other References: | Jones et. al. (Tetrahedron, 1996, 52(26), pp. 8707-8724). cited by examiner Neidle, Stephen, (Cancer Drug Design and Discovery, ed. (Elsevier/Academic Press, 2008) pp. 427-431). cited by examiner International Search Report for PCT/FR2007/001287, mailed Apr. 10, 2008. cited by applicant Jones, R. Alan, et al., “Extended Heterocyclic Systems 1. The Synthesis and Characterisation of Pyrrolylpyridines, Alternating Pyrrole:Pyridine Oligomers and Polymers, and Related Systems”, Tetrahedron, vol. 52, No. 26, (Jun. 1996), pp. 8707-8724. cited by applicant Baxter, Paul N. W., et al., “Self-Assembly and Structure of Interconverting Multinuclear Inorganic Arrays: A [4×5]AgI20 Grid and an AgI10 Quadruple Helicate”, Chemistry—A European Journal, vol. 6, No. 24, (Dec. 15, 2000), pp. 4510-4517. cited by applicant Coates, William J., et al., “1,4-Bis(3-oxo-2,3-dihydropyridazin-6-yl)benzene Analogues: Potent Phosphodiesterase Inhibitors and Inodilators”, Journal of Medicinal Chemistry, vol. 33, No. 6, (1990), pp. 1735-1741. cited by applicant |
| Primary Examiner: | Moore, Susanna |
| Attorney, Agent or Firm: | Nixon & Vanderhye P.C. |
| رقم الانضمام: | edspgr.09034873 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |