Patent
Antigen peptide and uses thereof
| العنوان: | Antigen peptide and uses thereof |
|---|---|
| Patent Number: | 9,266,922 |
| تاريخ النشر: | February 23, 2016 |
| Appl. No: | 14/122937 |
| Application Filed: | May 31, 2012 |
| مستخلص: | The invention relates to antigen peptide derived from the Nectin4 and its use for preventing and treating cancer. |
| Inventors: | Lopez, Marc (Marseilles, FR); Olive, Daniel (Marseilles, FR) |
| Assignees: | INSERM (Institut National de la Sante et de la Recherche Medicale) (Paris, FR), Universite d'Aix Marseille (Marseilles, FR), Institut Jean Paoli & Irene Calmettes (Marseilles, FR) |
| Claim: | 1. A genetically modified T lymphocyte that recognizes specifically an antigen peptide in complex with human leukocyte antigen A2 (HLA-A2), wherein said antigen peptide comprises an amino acid motif having the amino acid sequence: VLVPPLPSL (SEQ ID NO: 2). |
| Claim: | 2. A composition for adoptive therapy comprising a T lymphocyte according to claim 1 . |
| Patent References Cited: | 2010/0297006 November 2010 Raitano et al. 2004/016799 February 2004 2006/014999 February 2006 |
| Other References: | A—Geneseq ADK88377, 2004. cited by examiner Palmer et al (J. Immunol. 2004, 173: 72009-7216). cited by examiner Pittet et al (PNAS, 2007, 104(30): 12457-12461). cited by examiner Rossig and Brenner (Molec. Ther. 2004, 10(1): 5-18). cited by examiner Goodsell, D.S. (RCSB Protein Data Bank, 2005, 10.221-/rcsb—pdb/mom—2005—2). cited by examiner Celis et al (Mol. Immunol. 1994, 31(18): 1423-1430). cited by examiner Ochoa-Garay et al (Mol. Immunol. 1997, 34(3): 273-281). cited by examiner Karin et al (J. Exp. Med., 1994, 180, 2227-2237). cited by examiner Kalos and June (Immunity, 2013, 39: 49-60). cited by examiner Dermer (Bio/Technology, 1994, 12:320). cited by examiner Freshney (Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p4). cited by examiner Zips et al (In Vivo, 2005, 19:1-7). cited by examiner Fabre-Lafay et al., “Nectin-4 is a new histological and serological tumor associated marker for breast cancer”, BMC Cancer, May 2, 2007, p. 16PP, vol. 7, No. 73. cited by applicant |
| Assistant Examiner: | Dibrino, Marianne |
| Primary Examiner: | Szperka, Michael |
| Attorney, Agent or Firm: | Whitham Curtis Christofferson & Cook, PC |
| رقم الانضمام: | edspgr.09266922 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |