التفاصيل البيبلوغرافية
| العنوان: |
Method of screening pigs for resistance to salmonellosis |
| Document Number: |
20050064525 |
| تاريخ النشر: |
March 24, 2005 |
| Appl. No: |
10/485024 |
| Application Filed: |
July 30, 2002 |
| مستخلص: |
The present invention relates to methods for assessing an animal's susceptibility to bacterial infection. Methods for selecting suitable breeding animals are also provided. |
| Inventors: |
Kreukniet, Marijke (Bs Vught, NL); Van Diemen, Pauline (Berkshire, GB); Bumstead, Nat (Berkshire, GB); Bumstead, Janene (Compton near Newbury Berkshire, GB); Wallis, Tim (Berkshire, GB); Galina-Pantoja, Lucina (Hendersonville, TN, US) |
| Claim: |
1. a method for assessing an animal's susceptibility to bacterial infection, which comprises measuring at least one immune function of the animal: |
| Claim: |
2. A method as claimed in claim 1, wherein the immune function is measured prior to infection. |
| Claim: |
3. A method as claimed in claim 2 wherein the method comprises determining the intrinsic activity of non-stimulated polymorphonuclear neutrophils (PMNs). |
| Claim: |
4. A method as claimed in claim 2 wherein the method comprises measuring lymphocyte proliferation following appropriate stimulation with a mitogen. |
| Claim: |
5. A method as claimed in claim 3 wherein the intrinsic activity is measured by means of measuring oxidative burst response. |
| Claim: |
6. A method as claimed in claim 4 wherein lymphocyte proliferation is measured following stimulation by Concavalin A (Con A). |
| Claim: |
7. A method as claimed in claim 1, wherein the immune function is measured post infection. |
| Claim: |
8. A method as claimed in claim 7, which comprises determining the number of neutrophils in a sample from the animal. |
| Claim: |
9. A method as claimed in claim 7, wherein the method comprises measuring the response to anti-LPS antibody. |
| Claim: |
10. A method as claimed in claim 7, wherein the method comprises monitoring the pyrexic response. |
| Claim: |
11. A method as claimed in any one of claims 1 to 10 wherein the assessment is carried out in respect of Salmonella infection. |
| Claim: |
12. A method as claimed in claim 1 wherein the assessment is carried out on a blood sample obtained from the animal. |
| Claim: |
13. A method of selecting animals for suitability as breeding animals which comprises carrying out a method as defined in claim 1. |
| Claim: |
14. A method as claimed in any one of claim 1 wherein the animal is a mammal. |
| Claim: |
15. A method as claimed in claim 1 wherein the animal is a pig. |
| Current U.S. Class: |
435007/320 |
| رقم الانضمام: |
edspap.20050064525 |
| قاعدة البيانات: |
USPTO Patent Applications |
