التفاصيل البيبلوغرافية
العنوان:
Genome-wide association study of germline variants and breast cancer-specific mortality
المؤلفون:
Escala-Garcia, Maria , Guo, Qi , Doerk, Thilo , Canisius, Sander , Keeman, Renske , Dennis, Joe , Beesley, Jonathan , Lecarpentier, Julie , Bolla, Manjeet K. , Wang, Qin , Abraham, Jean , Andrulis, Irene L. , Anton-Culver, Hoda , Arndt, Volker , Auer, Paul L. , Beckmann, Matthias W. , Behrens, Sabine , Benitez, Javier , Bermisheva, Marina , Bernstein, Leslie , Blomqvist, Carl , Boeckx, Bram , Bojesen, Stig E. , Bonanni, Bernardo , Borresen-Dale, Anne-Lise , Brauch, Hiltrud , Brenner, Hermann , Brentnall, Adam , Brinton, Louise , Broberg, Per , Brock, Ian W. , Brucker, Sara Y. , Burwinkel, Barbara , Caldas, Carlos , Caldes, Trinidad , Campa, Daniele , Canzian, Federico , Carracedo, Angel , Carter, Brian D. , Castelao, Jose E. , Chang-Claude, Jenny , Chanock, Stephen J. , Chenevix-Trench, Georgia , Cheng, Ting-Yuan David , Chin, Suet-Feung , Clarke, Christine L. , Cordina-Duverger, Emilie , Couch, Fergus J. , Cox, David G. , Cox, Angela , Cross, Simon S. , Czene, Kamila , Daly, Mary B. , Devilee, Peter , Dunn, Janet A. , Dunning, Alison M. , Durcan, Lorraine , Dwek, Miriam , Earl, Helena M. , Ekici, Arif B. , Eliassen, A. Heather , Ellberg, Carolina , Engel, Christoph , Eriksson, Mikael , Evans, D. Gareth , Figueroa, Jonine , Flesch-Janys, Dieter , Flyger, Henrik , Gabrielson, Marike , Gago-Dominguez, Manuela , Galle, Eva , Gapstur, Susan M. , Garcia-Closas, Montserrat , Garcia-Saenz, Jose A. , Gaudet, Mia M. , George, Angela , Georgoulias, Vassilios , Giles, Graham G. , Glendon, Gord , Goldgar, David E. , Gonzalez-Neira, Anna , Alnaes, Grethe I. Grenaker , Grip, Mervi , Guenel, Pascal , Haeberle, Lothar , Hahnen, Eric , Haiman, Christopher A. , Hakansson, Niclas , Hall, Per , Hamann, Ute , Hankinson, Susan , Harkness, Elaine F. , Harrington, Patricia A. , Hart, Steven N. , Hartikainen, Jaana M. , Hein, Alexander , Hillemanns, Peter , Hiller, Louise , Holleczek, Bernd , Hollestelle, Antoinette , Hooning, Maartje J. , Hoover, Robert N. , Hopper, John L. , Howell, Anthony , Huang, Guanmengqian , Humphreys, Keith , Hunter, David J. , Janni, Wolfgang , John, Esther M. , Jones, Michael E. , Jukkola-Vuorinen, Arja , Jung, Audrey , Kaaks, Rudolf , Kabisch, Maria , Kaczmarek, Katarzyna , Kerin, Michael J. , Khan, Sofia , Khusnutdinova, Elza , Kiiski, Johanna, I , Kitahara, Cari M. , Knight, Julia A. , Ko, Yon-Dschun , Koppert, Linetta B. , Kosma, Veli-Matti , Kraft, Peter , Kristensen, Vessela N. , Kruger, Ute , Kuehl, Tabea , Lambrechts, Diether , Le Marchand, Loic , Lee, Eunjung , Lejbkowicz, Flavio , Li, Lian , Lindblom, Annika , Lindstrom, Sara , Linet, Martha , Lissowska, Jolanta , Lo, Wing-Yee , Loibl, Sibylle , Lubinski, Jan , Lux, Michael P. , MacInnis, Robert J. , Maierthaler, Melanie , Maishman, Tom , Makalic, Enes , Mannermaa, Arto , Manoochehri, Mehdi , Manoukian, Siranoush , Margolin, Sara , Martinez, Maria Elena , Mavroudis, Dimitrios , McLean, Catriona , Meindl, Alfons , Middha, Pooja , Miller, Nicola , Milne, Roger L. , Moreno, Fernando , Mulligan, Anna Marie , Mulot, Claire , Nassir, Rami , Neuhausen, Susan L. , Newman, William T. , Nielsen, Sune F. , Nordestgaard, Borge G. , Norman, Aaron , Olsson, Hakan , Orr, Nick , Pankratz, V. Shane , Park-Simon, Tjoung-Won , Perez, Jose I. A. , Perez-Barrios, Clara , Peterlongo, Paolo , Petridis, Christos , Pinchev, Mila , Prajzendanc, Karoliona , Prentice, Ross , Presneau, Nadege , Prokofieva, Darya , Pylkas, Katri , Rack, Brigitte , Radice, Paolo , Ramachandran, Dhanya , Rennert, Gadi , Rennert, Hedy S. , Rhenius, Valerie , Romero, Atocha , Roylance, Rebecca , Saloustros, Emmanouil , Sawyer, Elinor J. , Schmidt, Daniel F. , Schmutzler, Rita K. , Schneeweiss, Andreas , Schoemaker, Minouk J. , Schumacher, Fredrick , Schwentner, Lukas , Scott, Rodney J. , Scott, Christopher , Seynaeve, Caroline , Shah, Mitul , Simard, Jacques , Smeets, Ann , Sohn, Christof , Southey, Melissa C. , Swerdlow, Anthony J. , Talhouk, Aline , Tamimi, Rulla M. , Tapper, William J. , Teixeira, Manuel R. , Tengstrom, Maria , Terry, Mary Beth , Thoene, Kathrin , Tollenaar, Rob A. E. M. , Tomlinson, Ian , Torres, Diana , Truong, Therese , Turman, Constance , Turnbull, Clare , Ulmer, Hans-Ulrich , Untch, Michael , Vachon, Celine , van Asperen, Christi J. , van den Ouweland, Ans M. W. , van Veen, Elke M. , Wendt, Camilla , Whittemore, Alice S. , Willett, Walter , Winqvist, Robert , Wolk, Alicja , Yang, Xiaohong R. , Zhang, Yan , Easton, Douglas F. , Fasching, Peter A. , Nevanlinna, Heli , Eccles, Diana M. , Pharoah, Paul D. P. , Schmidt, Marjanka K.
المصدر:
British Journal of Cancer . 120(6):647-657
الوصف:
BACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using similar to 10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). RESULTS: We did not find any variant associated with breast cancer-specific mortality at P<5 x 10(-8). For ER-positive disease, the most significantly associated variant was chr7:rs4717568 (BFDP = 7%, P = 1.28 x 10(-7), hazard ratio [HR] = 0.88, 95% confidence interval [ CI] = 0.84-0.92); the closest gene is AUTS2. For ER-negative disease, the most significant variant was chr7: rs67918676 (BFDP = 11%, P = 1.38 x 10(-7), HR = 1.27, 95% CI = 1.16-1.39); located within a long intergenic non-coding RNA gene (AC004009.3), close to the HOXA gene cluster. CONCLUSIONS: We uncovered germline variants on chromosome 7 at BFDP <15% close to genes for which there is biological evidence related to breast cancer outcome. However, the paucity of variants associated with mortality at genome-wide significance underpins the challenge in providing genetic-based individualised prognostic information for breast cancer patients.
وصف الملف:
print
الوصول الحر:
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419403Test
قاعدة البيانات:
SwePub
