Comparative genomic analysis of three Leishmania species that cause diverse human disease.
| العنوان: | Comparative genomic analysis of three Leishmania species that cause diverse human disease. |
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| المؤلفون: | Peacock, Christopher S, Seeger, Kathy, Harris, David, Murphy, Lee, Ruiz, Jeronimo C, Quail, Michael A, Peters, Nick, Adlem, Ellen, Tivey, Adrian, Aslett, Martin, Kerhornou, Arnaud, Ivens, Alasdair, Fraser, Audrey, Rajandream, Marie-Adele, Carver, Tim, Norbertczak, Halina, Chillingworth, Tracey, Hance, Zahra, Jagels, Kay, Moule, Sharon, Ormond, Doug, Rutter, Simon, Squares, Rob, Whitehead, Sally, Rabbinowitsch, Ester, Arrowsmith, Claire, White, Brian, Thurston, Scott, Bringaud, Frédéric, Baldauf, Sandra L, Faulconbridge, Adam, Jeffares, Daniel, Depledge, Daniel P, Oyola, Samuel O, Hilley, James D, Brito, Loislene O, Tosi, Luiz R O, Barrell, Barclay, Cruz, Angela K, Mottram, Jeremy C, Smith, Deborah F, Berriman, Matthew |
| المصدر: | Nature Genetics. 39(7):839-847 |
| مصطلحات موضوعية: | Amino Acid Sequence, Animals, Genome, Genomics, Humans, Leishmania/*genetics, Leishmania braziliensis/genetics, Leishmania infantum/genetics, Leishmania major/genetics, Leishmaniasis/*parasitology, Leishmaniasis, Cutaneous/parasitology, Visceral/parasitology, Molecular Sequence Data, NATURAL SCIENCES, Biology, NATURVETENSKAP, Biologi |
| الوصف: | Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader–associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage. |
| وصف الملف: | |
| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-15051Test http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17572675&dopt=CitationTest |
| قاعدة البيانات: | SwePub |
| تدمد: | 10614036 15461718 |
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| DOI: | 10.1038/ng2053 |