المؤلفون: Prince, H. Miles Miles, Geskin, Larisa J, Akilov, Oleg E, Kuzel, Timothy M., Querfeld, Christiane, Ooi, Chean Eng, Xing, Dongyuan, Sauter, Nicholas, Singh, Preeti, Czuczman, Myron, Foss, Francine M.

المصدر: Blood; November 2022, Vol. 140 Issue: 1, Number 1 Supplement 1 p6577-6578, 2p

المؤلفون: Prince, H. Miles Miles, Geskin, Larisa J, Akilov, Oleg E, Kuzel, Timothy M., Querfeld, Christiane, Ooi, Chean Eng, Xing, Dongyuan, Sauter, Nicholas, Singh, Preeti, Czuczman, Myron, Foss, Francine M.

المصدر: Blood; November 2022, Vol. 140 Issue: Supplement 1 p6577-6578, 2p

المؤلفون: Foss, Francine M., Kim, Youn H., Prince, H. Miles Miles, Kuzel, Timothy M., Yannakou, Costas K., Ooi, Chean Eng, Xing, Dongyuan, Sauter, Nicholas, Singh, Preeti, Czuczman, Myron, Duvic, Madeleine

المصدر: Blood; November 2022, Vol. 140 Issue: Supplement 1 p1491-1492, 2p

المؤلفون: Foss, Francine M., Kim, Youn H., Prince, H. Miles Miles, Kuzel, Timothy M., Yannakou, Costas K., Ooi, Chean Eng, Xing, Dongyuan, Sauter, Nicholas, Singh, Preeti, Czuczman, Myron, Duvic, Madeleine

المصدر: Blood; November 2022, Vol. 140 Issue: 1, Number 1 Supplement 1 p1491-1492, 2p

المؤلفون: Lee, Joyce M., Rhee, Kirsten, O'Grady, Michael J., Basu, Anirban, Winn, Aaron, John, Priya, Meltzer, David O., Kollman, Craig, Laffel, Lori M., Lawrence, Jean M., Tamborlane, William V., Wysocki, Tim, Xing, Dongyuan, Huang, Elbert S.

المصدر: Medical Care; October 2011, Vol. 49 Issue: 10 p924-931, 8p

مستخلص: We studied health utilities in patients with type 1 diabetes to understand potential differences in health utilities as function of age, type of respondent (self report vs. proxy report), and method of assessment (direct vs. indirect).

المؤلفون: Hovorka, Roman, Allen, Janet M, Elleri, Daniela, Chassin, Ludovic J, Harris, Julie, Xing, Dongyuan, Kollman, Craig, Hovorka, Tomas, Larsen, Anne Mette F, Nodale, Marianna, De Palma, Alessandra, Wilinska, Malgorzata E, Acerini, Carlo L, Dunger, David B

المصدر: The Lancet; February 2010, Vol. 375 Issue: 9716 p743-751, 9p

مستخلص: Closed-loop systems link continuous glucose measurements to insulin delivery. We aimed to establish whether closed-loop insulin delivery could control overnight blood glucose in young people.

المؤلفون: Hovorka, Roman, Kumareswaran, Kavita, Harris, Julie, Allen, Janet M, Elleri, Daniela, Xing, Dongyuan, Kollman, Craig, Nodale, Marianna, Murphy, Helen R, Dunger, David B, Amiel, Stephanie A, Heller, Simon R, Wilinska, Malgorzata E, Evans, Mark L

المصدر: BMJ (British Medical Journal); 2011, Vol. 342 Issue: 4 pd1855-d1855, 1p

مستخلص: OBJECTIVE: To compare the safety and efficacy of overnight closed loop delivery of insulin (artificial pancreas) with conventional insulin pump therapy in adults with type 1 diabetes. Design Two sequential, open label, randomised controlled crossover, single centre studies. Setting Clinical research facility. Participants 24 adults (10 men, 14 women) with type 1 diabetes, aged 18-65, who had used insulin pump therapy for at least three months: 12 were tested after consuming a medium sized meal and the other 12 after consuming a larger meal accompanied by alcohol. Intervention During overnight closed loop delivery, sensor measurements of glucose were fed into a computer algorithm, which advised on insulin pump infusion rates at 15 minute intervals. During control nights, conventional insulin pump settings were applied. One study compared closed loop delivery of insulin with conventional pump therapy after a medium sized evening meal (60 g of carbohydrates) at 1900, depicting the scenario of "eating in." The other study was carried out after a later large evening meal (100 g of carbohydrates) at 2030, accompanied by white wine (0.75 g/kg ethanol) and depicted the scenario of "eating out." MAIN OUTCOME MEASURES: The primary outcome was the time plasma glucose levels were in target (3.91-8.0 mmol/L) during closed loop delivery and a comparable control period. Secondary outcomes included pooled data analysis and time plasma glucose levels were below target (≤3.9 mmol/L). RESULTS: For the eating in scenario, overnight closed loop delivery of insulin increased the time plasma glucose levels were in target by a median 15% (interquartile range 3-35%), P=0.002. For the eating out scenario, closed loop delivery increased the time plasma glucose levels were in target by a median 28% (2-39%), P=0.01. Analysis of pooled data showed that the overall time plasma glucose was in target increased by a median 22% (3-37%) with closed loop delivery (P<0.001). Closed loop delivery reduced overnight time spent hypoglycaemic (plasma glucose ≤3.9 mmol/L) by a median 3% (0-20%), P=0.04, and eliminated plasma glucose concentrations below 3.0 mmol/L after midnight. CONCLUSION: These two small crossover trials suggest that closed loop delivery of insulin may improve overnight control of glucose levels and reduce the risk of nocturnal hypoglycaemia in adults with type 1 diabetes. Trial registration ClinicalTrials.gov NCT00910767 and NCT00944619.