التفاصيل البيبلوغرافية
| العنوان: |
Comparison of clinicopathological features and treatment outcomes in aggressive primary intestinal B- and T/NK-cell lymphomas. |
| المؤلفون: |
Ma, Wei-Li, Yeh, Kun-Huei, Yao, Ming, Tang, Jih-Luh, Lin, Chung-Wu, Wang, Yu-Ting, Yeh, Yi-Chun, Wang, Hsiu-Po, Cheng, Ann-Lii, Kuo, Sung-Hsin |
| المصدر: |
Journal of the Formosan Medical Association; Jan2021:Part 2, Vol. 120 Issue 1, p293-302, 10p |
| مصطلحات موضوعية: |
PROGNOSIS, TREATMENT effectiveness, SURVIVAL analysis (Biometry), LARGE intestine, INTESTINAL perforation, EXTRANODAL NK-T-cell lymphoma, RESEARCH, RESEARCH methodology, B cell lymphoma, RETROSPECTIVE studies, EVALUATION research, MEDICAL cooperation, COMPARATIVE studies, IMMUNOPHENOTYPING, T-cell lymphoma |
| الشركة/الكيان: |
WORLD Health Organization |
| مستخلص: |
Background: Primary intestinal lymphomas (PILs) are rare, and this study compared the clinical outcomes of aggressive primary intestinal B-cell lymphomas (aB-PILs) and T/natural killer-cell lymphomas (T/NK-PILs).Methods: The clinical information of patients diagnosed with aggressive PILs at our institution between 1995 and 2015 were retrospectively investigated. Pathological subtypes were confirmed according to the 2016 revision of the World Health Organization classification. The correlation between clinicopathological features and overall survival (OS) was determined using univariate and multivariate analyses.Results: Cases of T/NK-PILs had higher initial bowel perforation incidence (67% vs. 7%, P < 0.001) and lower complete response rate to first-line chemotherapy regimens (22% vs. 69%, P = 0.009) than aB-PILs. Patients with aB-PILs had a better 5-year event-free survival rate (55.8% vs. 13.9%, P = 0.026) and a 5-year OS rate (74.3% vs. 29.6%, P = 0.036) than those with T/NK-cell lymphomas. Multivariate analysis identified that female gender and stage III/IV were unfavorable prognostic factors. Among the 54 patients with diffuse large B-cell lymphoma (DLBCL), those with International Prognostic Index (IPI) scores of 0-2 had a better 5-year OS rate than those with scores of 3-5 (84.2% vs. 46.8%, P = 0.002). IPI scores of 3-5 (P = 0.026) and tumors located in the large intestine (P = 0.015) were poor prognostic factors based on the multivariate analysis.Conclusion: The prognosis of T/NK-PILs was less favorable than that of aB-PILs. Female gender, stage III/IV disease, DLBCL with IPI scores of 3-5, or tumors in the large intestine were poor prognostic factors. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of the Formosan Medical Association is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Supplemental Index |
Full Text Finder