دورية
Myeloablative Haploidentical Transplant as an Alternative to Matched Sibling Transplant for Peripheral T-Cell Lymphomas
| العنوان: | Myeloablative Haploidentical Transplant as an Alternative to Matched Sibling Transplant for Peripheral T-Cell Lymphomas |
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| المؤلفون: | Zhenyang, Gu, Nainong, Li, Xiaoxiong, Wu, Maihong, Wang, Xiaorui, Fu, Zhao, Wang, Hanyun, Ren, Yuhang, Li, Xiaofan, Li, Yamei, Wu, Yao, Liu, Mingzhi, Zhang, Yini, Wang, Daihong, Liu, Yujun, Dong, Liangding, Hu, Wenrong, Huang |
| المصدر: | Cell Transplantation; November 2021, Vol. 30 Issue: 1 |
| مستخلص: | The number of HLA-haploidentical allogeneic hematopoietic stem-cell transplantation (Haplo-HSCT) is increasing. Comparative studies about Haplo-HSCT versus allo-HSCT with HLA-matched sibling donors (MSD-HSCT) have been tried in leukemias and B-cell lymphomas. Few studies were reported in Peripheral T-cell lymphomas (PTCLs). We performed a multicenter retrospective study about 52 patients with PTCLs undergoing Haplo-HSCT (n= 20) or MSD-HSCT (n= 32). All Haplo-HSCT recipients received antithymocyte globulin (ATG) based graft versus host disease (GVHD) prophylaxis. The median follow-up for all survivors was 38 months. The 100-day cumulative incidence of grade II to IV acute GVHD was similar (19% in the MSD-HSCT group versus 28% in the Haplo-HSCT group, P =0.52). The 2-year cumulative incidence of chronic GVHD (limited and extensive) after Haplo-HSCT (30%) was also similar with that in the MSD-HSCT group (50%, P =0.15). The 3-year relapse rates (33% vs 27%, P =0.84) and non-relapse mortality (21% vs 22%, P =0.78) did not differ between these two groups. There were also no differences in 3-year overall survival (OS) (48% vs 50%, P =0.78) and progression-free survival (47% vs 51%, P =0.95) between these two groups. On multivariate analysis, prognostic index for T-cell lymphoma (PIT) score (higher than 1: hazard ratio [HR], 4.0; P =0.003) and disease status (stable or progression disease before HSCT: HR, 2.8; P =0.03) were independent variables associated with worse OS. We concluded that ATG-based haplo-HSCT platform could work as an alternative to MSD-HSCT for patients with PTCLs. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 09636897 15553892 |
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| DOI: | 10.1177/0963689721999615 |