التفاصيل البيبلوغرافية
| العنوان: |
Coacervates of whey proteins to protect and improve the oral delivery of a bioactive molecule. |
| المؤلفون: |
Chapeau, Anne-Laure, Bertrand, Nicolas, Briard-Bion, Valérie, Hamon, Pascaline, Poncelet, Denis, Bouhallab, Saïd |
| المصدر: |
Journal of Functional Foods; Nov2017 Part A, Vol. 38, p197-204, 8p |
| مستخلص: |
The potentiality of heteroprotein complex coacervates as biocarrier for a bioactive was investigated. Vitamin B9 (B9), also known as folic acid, was encapsulated by complex coacervation of two whey proteins (WP), β-lactoglobulin and lactoferrin. The stability and bioavailability of formed B9-WP coacervates was then characterized. Under degradative conditions in vitro (UV light irradiation, and oxidation by H 2 O 2 ), WP coacervates protected the vitamin against chemical degradation. B9-WP coacervates also showed considerable physical stability over time when incorporated in real food matrices. Compared to unencapsulated B9, oral administration of B9-WP coacervates to healthy rats enhanced the plasma level of the vitamin. This improved bioavailability can be ascribed to the improvement in the solubility of B9 throughout the gastro-intestinal tract. We thus demonstrate the efficiency of WP coacervates as biocarrier for the protection and delivery of small bioactive molecules. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Functional Foods is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Supplemental Index |
