التفاصيل البيبلوغرافية
| العنوان: |
Indications of Rituximab in autoimmune diseases. |
| المؤلفون: |
Sanz, Iñaki |
| المصدر: |
Drug Discovery Today: Therapeutic Strategies; Mar2009, Vol. 6 Issue 1, p13-19, 7p |
| مصطلحات موضوعية: |
CLINICAL indications, RITUXIMAB, AUTOIMMUNE diseases, B cells, RHEUMATOID arthritis, MULTIPLE sclerosis, DIABETES, T cells |
| مستخلص: |
B cell targeted therapies are becoming widespread for the treatment of multiple autoimmune diseases including conditions such as Rheumatoid Arthritis, Multiple Sclerosis and Type ! diabetes typically considered as T cell mediated. This interest stems from the convergence of tremendous progress in understanding the multiple effector and regulatory roles played by B cells in regulating autoimmunity as well as in the promising results reported for B cell depletion in an ever expanding number of autoimmune diseases. This review will review current knowledge of Rituximab-induced B cell depletion in diseases where this therapy is either well established or represents a promising therapeutic avenue with potential to uncover important disease mechanisms. [Copyright &y& Elsevier] |
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| قاعدة البيانات: |
Supplemental Index |
