التفاصيل البيبلوغرافية
| العنوان: |
Impact of Less Invasive Left Ventricular Assist Device Implantation on Heart Transplant Outcomes. |
| المؤلفون: |
Riebandt, Julia, Wiedemann, Dominik, Sandner, Sigrid, Angleitner, Philipp, Zuckermann, Andreas, Schlöglhofer, Thomas, Laufer, Günther, Zimpfer, Daniel |
| المصدر: |
Seminars in Thoracic & Cardiovascular Surgery; Spring2022, Vol. 34 Issue 1, p148-156, 9p |
| مستخلص: |
Left ventricular assist device implantation without sternotomy (LIS) may simplify heart transplantation (HTX) by avoiding adhesions and eliminating the need for a re-sternotomy. This study investigates the impact of LIS LVAD implantation on HTX outcomes. A retrospective comparison of 46 patients undergoing HTX between 07/13 and 06/19 after conventional LVAD implantation with a full sternotomy (FS) and LIS LVAD implantation (LIS: n = 27 patients, 59%; FS: n = 19 patients, 41%) was performed. Endpoints were perioperative data including blood product use, de-novo formation of donor specific antibodies (DSAs) and survival. Patient demographics (mean age FS: 60.3 ± 9.3 years vs LIS 58.0 ± 7.7 years, P = 0.313; male gender FS: 84% vs LIS: 82%, P = 1.000; urgent HTX FS: 16% vs LIS 18%, P = 1.000) were comparable between LIS and FS patients. The primary finding was a significantly higher risk to develop de novo donor specific antibodies (DSAs) after HTX in patients of the FS group (FS: 36% vs LIS: 4%; P = 0.006). LIS patients had a significant reduction of intraoperative packed red blood cells (PRBCs) use (LIS: 4 (IQR 2-7) Units vs FS: 7 (IQR 4-8) Units; P = 0.045). Other adverse events rates and in-hospital mortality (LIS: 7% vs FS 5%, P = 1.000) were comparable between both groups. LIS LVAD reduces formation of donor specific antibodies after HTX. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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