التفاصيل البيبلوغرافية
| العنوان: |
Unraveling, contributing factors to the severity of postprandial hypoglycemia after gastric bypass surgery. |
| المؤلفون: |
Herzig, David, Schiavon, Michele, Tripyla, Afroditi, Lehmann, Vera, Meier, Jasmin, Jainandunsing, Sjaam, Kuenzli, Christina, Stauffer, Thomas P., Dalla Man, Chiara, Bally, Lia |
| المصدر: |
Surgery for Obesity & Related Diseases; May2023, Vol. 19 Issue 5, p467-472, 6p |
| مستخلص: |
Despite the increasing prevalence of postbariatric hypoglycemia (PBH), a late metabolic complication of bariatric surgery, our understanding of its diverse manifestations remains incomplete. To contrast parameters of glucose-insulin homeostasis in 2 distinct phenotypes of PBH (mild versus moderate hypoglycemia) based on nadir plasma glucose. University Hospital (Bern, Switzerland). Twenty-five subjects with PBH following gastric bypass surgery (age, 41 ± 12 years; body mass index, 28.1 ± 6.1kg/m2) received 75g of glucose with frequent blood sampling for glucose, insulin, C-peptide, and glucagon-like peptide 1 (GLP)-1. Based on nadir plasma glucose (-9∗min-1; P =.003). Despite an increased GLP-1 exposure in L2 compared to L1 PBH (50.7 versus 31.9pmol∗L-1∗min∗102; P =.021), no significant difference in PI was observed (P =.204). No significant differences were observed for HE, Ra, and SI. Our results suggest that higher insulin exposure in PBH patients with lower postprandial nadir glucose values mainly relate to a higher responsiveness to glucose, rather than GLP-1. [Display omitted] • Heterogeneity of postbariatric hypoglycemia in terms of its clinical manifestation is high. • Postbariatric hypoglycemia patients with low postprandial glucose levels display higher insulin exposure. • Differences in glucose, rather than GLP-1 β-cell stimulation is associated with higher insulin levels. [ABSTRACT FROM AUTHOR] |
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