التفاصيل البيبلوغرافية
| العنوان: |
Influence of thyroid dysfunction on liver lipid peroxidation and antioxidant status in experimental rats. |
| المؤلفون: |
Messarah, Mahfoud, Boumendjel, Amel, Chouabia, Amel, Klibet, Fahima, Abdennour, Cherif, Boulakoud, Mohamed Salah, Feki, Abdelfattah El |
| المصدر: |
Experimental & Toxicologic Pathology; May2010, Vol. 62 Issue 3, p301-310, 10p |
| مصطلحات موضوعية: |
ANTIOXIDANTS, THYROID diseases, LIPIDS, LABORATORY rats, HYPERTHYROIDISM, OXIDATIVE stress, THYROXINE, SUPEROXIDE dismutase, ALKALINE phosphatase, LACTATE dehydrogenase |
| مستخلص: |
Abstract: The purpose of this study was to evaluate the effects of dysthyroidism on lipid peroxidation, antioxidants status, liver, and serum dysfunction parameters in the hypo-/hyperthyroidism-induced rats. Hypothyroidism and hyperthyroidism conditions were induced for 5 weeks by administration of 0.05% benzythiouracile (BTU) and l-thyroxine sodium salt (0.0012%), in drinking water, respectively. The enzymatic activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and the lipid peroxidation product; thiobarbituric acid reacting substances (TBARS) were measured in liver as indicators of oxidative damage. However, liver dysfunction parameters represented by the activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and gamma glutamyl transferase (GGT), were measured in serum. In hyperthyroidism rats, the TBARS contents of liver have significantly increased compared to those in hypothyroid rats and the controls (p<0.001), associated with a fall of the total antioxidant status (TAS) in the serum of the hyperthyroid rats. The SOD, CAT, and GPx activities in liver of hyperthyroid rats have significantly increased compared to hypothyroid rats and the controls (p<0.001). The AST, ALT, LDH, GGT, and ALP activities increased in the hyperthyroidism rats (p<0.05). We conclude that thyroid dysfunction induces oxidative stress and modifies some biochemical parameters of liver. Our results show the occurrence of a state of oxidizing stress in relation to hyperthyroidism. [Copyright &y& Elsevier] |
|
Copyright of Experimental & Toxicologic Pathology is the property of Urban & Fischer Verlag and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Supplemental Index |
