التفاصيل البيبلوغرافية
| العنوان: |
Prenatal exposure to bisphenol analogues and digit ratio in children at ages 4 and 6 years: A birth cohort study. |
| المؤلفون: |
Wang, Ziliang, Zhou, Yan, Liang, Hong, Miao, Maohua, Chen, Yafei, Zhang, Xiaotian, Song, Xiuxia, Yuan, Wei |
| المصدر: |
Environmental Pollution; Jun2021, Vol. 278, pN.PAG-N.PAG, 1p |
| مصطلحات موضوعية: |
GENERALIZED estimating equations, COHORT analysis, VERNIERS, CHILD development, REPRODUCTIVE health |
| مستخلص: |
Bisphenol analogues (BPs), including bisphenol A (BPA), have been shown to exhibit similar endocrine disrupting activities. However, epidemiological evidence on the reproductive and developmental toxicities of BPs other than BPA is scarce. The second to fourth digit ratio (2D:4D), an endocrine-sensitive endpoint, has been suggested to be a biomarker of prenatal sex steroid exposure and associated with reproductive outcomes in later life. Using the data of 545 mother-child pairs from the Shanghai-Minhang Birth Cohort Study, we prospectively assessed the effects of prenatal exposure to BPs on 2D:4D in children at ages 4 and 6 years. Single-spot urine samples were collected in the third trimester and analyzed for BPs. Digit lengths were measured using a vernier caliper in children at ages 4 and 6 years, and the 2D:4D values for both hands were calculated. A multivariable linear regression model was applied to examine associations between prenatal BPs exposure and 2D:4D digit ratios at each age separately. The generalized estimating equation (GEE) model was used to deal with repeated 2D:4D measures obtained at ages 4 and 6 years. We found that prenatal exposure to BPA alternatives including BPF, BPS, and BPAF was associated with higher digit ratio in boys and/or girls (feminizing), while TCBPA, a halogenated bisphenol, was associated with lower 2D:4D in boys (masculinizing). These associations were more pronounced at 4 years of age, and tended to remain after further considering the potential confounding from prenatal co-exposure to other BPs and childhood BPs exposure. Our study provides epidemiological evidence that BPs exposure during pregnancy may alter the digit development in children, indicative of disrupted reproductive development in later life. Given these new findings, further studies are needed to corroborate our results. [Display omitted] • The toxicities of BPs other than BPA in humans are poorly understood. • The 2D:4D may be an useful indicator to study the effect of prenatal EDCs exposure. • Prenatal exposure to BPA alternatives was associated with offspring's higher 2D:4D. • Prenatal BPs exposure may be associated with reproductive development in offspring. [ABSTRACT FROM AUTHOR] |
|
Copyright of Environmental Pollution is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Supplemental Index |
