التفاصيل البيبلوغرافية
| العنوان: |
Post-mortem assessment in vascular dementia: advances and aspirations |
| المؤلفون: |
McAleese, K., Alafuzoff, I., Charidimou, A., De Reuck, J., Grinberg, L., Hainsworth, A., Hortobagyi, T., Ince, P., Jellinger, K., Gao, J., Kalaria, R., Kovacs, G., Kövari, E., Love, S., Popovic, M., Skrobot, O., Taipa, R., Thal, D., Werring, D., Wharton, S., Attems, J. |
| المساهمون: |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
| بيانات النشر: |
BioMed Central, 2016. |
| سنة النشر: |
2016 |
| مصطلحات موضوعية: |
Vascular dementia, Vascular cognitive impairment, Cerebrovascular disease, Cerebrovascular lesions, Neuropathology, Magnetic resonance imaging, Post-mortem MRI, Mixed dementia |
| الوصف: |
Background Cerebrovascular lesions are a frequent finding in the elderly population. However, the impact of these lesions on cognitive performance, the prevalence of vascular dementia, and the pathophysiology behind characteristic in vivo imaging findings are subject to controversy. Moreover, there are no standardised criteria for the neuropathological assessment of cerebrovascular disease or its related lesions in human post-mortem brains, and conventional histological techniques may indeed be insufficient to fully reflect the consequences of cerebrovascular disease. Discussion Here, we review and discuss both the neuropathological and in vivo imaging characteristics of cerebrovascular disease, prevalence rates of vascular dementia, and clinico-pathological correlations. We also discuss the frequent comorbidity of cerebrovascular pathology and Alzheimer’s disease pathology, as well as the difficult and controversial issue of clinically differentiating between Alzheimer’s disease, vascular dementia and mixed Alzheimer’s disease/vascular dementia. Finally, we consider additional novel approaches to complement and enhance current post-mortem assessment of cerebral human tissue. Conclusion Elucidation of the pathophysiology of cerebrovascular disease, clarification of characteristic findings of in vivo imaging and knowledge about the impact of combined pathologies are needed to improve the diagnostic accuracy of clinical diagnoses. |
| الوصف (مترجم): |
KEM is currently supported by the by the Alzheimer’s Society, UK. LTG was funded by institutional NIH grants (P50AG023501, P01AG019724 and R01 AG040311). TH has received support from the Hungarian Brain Research Program (KTIA_13_NAP-A-II/7). Cerebral tissue for some studies in this consensus was provided by the Newcastle Brain Tissue Resource, which is funded in part by a grant from the UK Medical Research Council (grant number G0400074) and by Brains for Dementia research, a joint venture between Alzheimer’s Society and Alzheimer’s Research UK. |
| نوع الوثيقة: |
journal article |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
BMC Med. 2016 Aug 26;14(1):129; 1741-7015 |
| DOI: |
10.1186/s12916-016-0676-5 |
| الإتاحة: |
http://hdl.handle.net/10400.16/2086Test |
| حقوق: |
open access |
| رقم الانضمام: |
rcaap.com.chporto.repositorio.chporto.pt.10400.16.2086 |
| قاعدة البيانات: |
RCAAP |
