دورية أكاديمية
Amidated and ibuprofen-conjugated kyotorphins promote neuronal rescue and memory recovery in cerebral hypoperfusion dementia model
| العنوان: | Amidated and ibuprofen-conjugated kyotorphins promote neuronal rescue and memory recovery in cerebral hypoperfusion dementia model |
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| المؤلفون: | Santos, Sónia Sá, Santos, Sara M., Pinto, Antónia R. T., Ramu, Vasanthakumar G., Heras, Montserrat, Bardaji, Eduard, Tavares, Isaura, Castanho, Miguel A. R. B. |
| المساهمون: | Repositório da Universidade de Lisboa |
| بيانات النشر: | Frontiers Media, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 2VO-dementia model, Chronic cerebral hypoperfusion, Cognitive impairment, Hippocampus, Kyotorphin derivatives, Neuroprotection |
| الوصف: | Copyright © 2016 Sá Santos, Santos, Pinto, Ramu, Heras, Bardaji, Tavares and Castanho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| الوصف (مترجم): | Chronic brain ischemia is a prominent risk factor for neurological dysfunction and progression for dementias, including Alzheimer's disease (AD). In rats, permanent bilateral common carotid artery occlusion (2VO) causes a progressive neurodegeneration in the hippocampus, learning deficits and memory loss as it occurs in AD. Kyotorphin (KTP) is an endogenous antinociceptive dipeptide whose role as neuromodulator/neuroprotector has been suggested. Recently, we designed two analgesic KTP-derivatives, KTP-amide (KTP-NH2) and KTP-NH2 linked to ibuprofen (IbKTP-NH2) to improve KTP brain targeting. This study investigated the effects of KTP-derivatives on cognitive/behavioral functions (motor/spatial memory/nociception) and hippocampal pathology of female rats in chronic cerebral hypoperfusion (2VO-rat model). 2VO-animals were treated with KTP-NH2 or IbKTP-NH2 for 7 days at weeks 2 and 5 post-surgery. After behavioral testing (week 6), coronal sections of hippocampus were H&E-stained or immunolabeled for the cellular markers GFAP (astrocytes) and NFL (neurons). Our findings show that KTP-derivatives, mainly IbKTP-NH2, enhanced cognitive impairment of 2VO-animals and prevented neuronal damage in hippocampal CA1 subfield, suggesting their potential usefulness for the treatment of dementia. Funding was provided by the Portuguese Agency Fundação para a Ciência e a Tecnologia SFRH/BPD/79542/2011 fellowship) |
| نوع الوثيقة: | journal article |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Front. Aging Neurosci. 8:1; 1663-4365 |
| DOI: | 10.3389/fnagi.2016.00001 |
| الإتاحة: | http://hdl.handle.net/10451/32813Test |
| حقوق: | open access |
| رقم الانضمام: | rcaap.com.ul.repositorio.ul.pt.10451.32813 |
| قاعدة البيانات: | RCAAP |
| DOI: | 10.3389/fnagi.2016.00001 |
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