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المؤلفون: Simone Di Micco, Veronica Di Sarno, Martina Rossi, Vincenzo Vestuto, Takumi Konno, Sara Novi, Mario Felice Tecce, Valeria Napolitano, Tania Ciaglia, Andrea Vitale, Isabel Maria Gomez-Monterrey, Giuseppe Bifulco, Alessia Bertamino, Carmine Ostacolo, Paolo Blasi, Alessio Fasano, Pietro Campiglia, Simona Musella
المساهمون: Simone Di Micco, Veronica DI SARNO, martina rossi, Vincenzo Vestuto, Takumi Konno, Sara Novi, Mario Felice TECCE, Valeria Napolitano, Tania CIAGLIA, Andrea Vitale, Isabel Maria Gomez Monterrey, Giuseppe Bifulco, Alessia Bertamino, Carmine Ostacolo, Paolo Blasi, Alessio Fasano, Pietro Campiglia, Simona Musella
المصدر: International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 725
مصطلحات موضوعية: Organic Chemistry, drug discovery, in silico studies, multidrug resistance, multicellular tumor spheroids, ATP-binding cassette, General Medicine, in silico studie, Catalysis, multicellular tumor spheroid, Computer Science Applications, Inorganic Chemistry, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy
وصف الملف: ELETTRONICO; application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97953843e8030fc1f0bb1977fafe9771Test
https://hdl.handle.net/11585/924253Test -
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المؤلفون: Malgorzata Magoch, Alastair G. McEwen, Valeria Napolitano, Benedykt Władyka, Grzegorz Dubin
المصدر: Molecules; Volume 28; Issue 11; Pages: 4407
مصطلحات موضوعية: Staphylococcus aureus, Organic Chemistry, staphopain, ScpA2, virulence factor, cysteine protease, X-ray crystallography, Pharmaceutical Science, Analytical Chemistry, Chemistry (miscellaneous), Drug Discovery, Molecular Medicine, Physical and Theoretical Chemistry
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf213799c354dc06ad5f7ee98e7d8c83Test
https://ruj.uj.edu.pl/xmlui/handle/item/312355Test -
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المؤلفون: Valeria Napolitano, Piotr Mróz, Monika Marciniak, Vishal C. Kalel, Charlotte A. Softley, Julian D. Janna Olmos, Bettina G. Tippler, Kenji Schorpp, Sarah Rioton, Tony Fröhlich, Oliver Plettenburg, Kamyar Hadian, Ralf Erdmann, Michael Sattler, Grzegorz M. Popowicz, Maciej Dawidowski, Grzegorz Dubin
المصدر: Eur. J. Med. Chem. 243:114778 (2022)
مصطلحات موضوعية: Pharmacology, Protein Transport, Trypanosoma, Structure-Activity Relationship, Organic Chemistry, Drug Discovery, Trypanosoma brucei brucei, Membrane Proteins, Chagas Disease, Glycosomal Protein Import, Hts, Human African Trypanosomiasis, Ppi Inhibition, Structure-based Drug Design, General Medicine, Microbodies, Trypanocidal Agents
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e15a3ec07e102366e8fc4ca9cc1dcdTest
https://pubmed.ncbi.nlm.nih.gov/36194937Test -
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المؤلفون: Valeria Napolitano, Agnieszka Dabrowska, Kenji Schorpp, André Mourão, Emilia Barreto-Duran, Malgorzata Benedyk, Pawel Botwina, Stefanie Brandner, Mark Bostock, Yuliya Chykunova, Anna Czarna, Grzegorz Dubin, Tony Fröhlich, Michael Hölscher, Malwina Jedrysik, Alex Matsuda, Katarzyna Owczarek, Magdalena Pachota, Oliver Plettenburg, Jan Potempa, Ina Rothenaigner, Florian Schlauderer, Klaudia Slysz, Artur Szczepanski, Kristin Greve-Isdahl Mohn, Bjorn Blomberg, Michael Sattler, Kamyar Hadian, Grzegorz Maria Popowicz, Krzysztof Pyrc
المصدر: Cell Chemical Biology
Cell chemical biology 29 (2022), Nr. 5
Cell chemical biology
Cell Chem. Bio. 29, 774-784.e8 (2022)مصطلحات موضوعية: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie, Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie, Clinical Biochemistry, coronavirus, Biochemistry, acriflavine, Antiviral Agents, Article, protease inhibitor, Mice, ddc:570, Drug Discovery, structural biology, Animals, Humans, Molecular Biology, Pandemics, Pharmacology, drug repurposing, SARS-CoV-2, COVID-19, protease, COVID-19 Drug Treatment, Molecular Docking Simulation, PLpro, Covid-19, Pl(pro), Sars-cov-2, Acriflavine, Coronavirus, Drug Repurposing, Protease, Protease Inhibitor, Structural Biology, ddc:540, Molecular Medicine
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531edc41a740649bff0588acda8eaf23Test
http://europepmc.org/articles/PMC8751734Test -
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المؤلفون: Valeria, Napolitano, Charlotte A, Softley, Artur, Blat, Vishal C, Kalel, Kenji, Schorpp, Till, Siebenmorgen, Kamyar, Hadian, Ralf, Erdmann, Michael, Sattler, Grzegorz M, Popowicz, Grzegorz, Dubin
المصدر: Sci. Rep. 12:14705 (2022)
مصطلحات موضوعية: Protein Transport, Trypanosoma, Multidisciplinary, Peroxisome-Targeting Signal 1 Receptor, Peroxisomes, Humans, Receptors, Cytoplasmic and Nuclear, Carrier Proteins, Microbodies, Peroxisomal Targeting Signal 2 Receptor
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2954316ccbeaa411769a876317f44d4eTest
https://ruj.uj.edu.pl/xmlui/handle/item/305330Test -
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المؤلفون: U. Helena Danielson, Helena Nordström, Tom Dzus, Valeria Napolitano, Giulia Opassi, Gerhard Klebe, Arne Lundin, Francesca Magari
المصدر: Protein Science
Protein Science : A Publication of the Protein Societyمصطلحات موضوعية: Chagas disease, Thermal shift assay, Trypanosoma cruzi, Fragment-based lead discovery, Farnesyl pyrophosphate, SPR, Biochemistry, Pyrophosphate, Catalysis, Article, Cofactor, 03 medical and health sciences, chemistry.chemical_compound, Magnesium, Luciferase, Molecular Biology, 030304 developmental biology, 0303 health sciences, biology, 030302 biochemistry & molecular biology, Biochemistry and Molecular Biology, Geranyltranstransferase, fragment screening, Articles, Surface Plasmon Resonance, binding efficiency, biology.organism_classification, farnesyl pyrophosphate synthase, chemistry, biology.protein, Target protein, Biokemi och molekylärbiologi
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4244925221396853671363436167464eTest
https://doi.org/10.1002/pro.3834Test -
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المؤلفون: Ekaterina L. Ratkova, Igor V. Tetko, Michael Sattler, Grzegorz Dubin, Valeria Napolitano, Roberto Fino, Maciej Dawidowski, Grzegorz M. Popowicz, Michael Sebastian Ostertag
المصدر: Chem. Commun. 56, 4360-4363 (2020)
Chemical Communicationsمصطلحات موضوعية: Pyrrolidines, Peroxisome-Targeting Signal 1 Receptor, In silico, Trypanosoma brucei brucei, Protozoan Proteins, Crystallography, X-Ray, Proof of Concept Study, 01 natural sciences, Catalysis, Protein–protein interaction, Structure-Activity Relationship, 03 medical and health sciences, Materials Chemistry, Humans, Computer Simulation, 030304 developmental biology, Envelope (waves), 0303 health sciences, Molecular Structure, 010405 organic chemistry, Chemistry, Metals and Alloys, Membrane Proteins, Water, General Chemistry, Orders of magnitude (mass), ddc, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Ceramics and Composites, Biophysics, Pyrazoles, Protein Multimerization, Protein Binding
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40869e66bf8d308bf2c99b2ca1f76db3Test
https://doi.org/10.1039/c9cc07714fTest -
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المؤلفون: Wolfgang Schliebs, Charlotte A Softley, Valeria Napolitano, Ryan Byrne, Dominik Lenhart, Michael Sattler, Grzegorz M Popowicz, Roberto Fino, Gisbert Schneider, Maciej Dawidowski, Vishal C. Kalel, Ralf Erdmann, Oliver Plettenburg
المصدر: J. Chem. Inf. Model. 61, 5256-5268 (2021)
Journal of Chemical Information and Modeling, 61 (10)مصطلحات موضوعية: Drug, Peroxisome-Targeting Signal 1 Receptor, General Chemical Engineering, media_common.quotation_subject, Receptors, Cytoplasmic and Nuclear, Computational biology, Library and Information Sciences, 01 natural sciences, Glycosome, 03 medical and health sciences, 030304 developmental biology, Trypanocidal agent, ADME, media_common, 0303 health sciences, 010405 organic chemistry, Chemistry, Membrane Proteins, General Chemistry, Peroxisome, Trypanocidal Agents, In vitro, ddc, 3. Good health, 0104 chemical sciences, Computer Science Applications, Repressor Proteins, Oxazepines, Drug development, Structural biology, Computer-Aided Design
وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/application/pdf; application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e957c50389039d33e3fd89dae22a34aTest
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63182Test -
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المؤلفون: Grzegorz M Popowicz, Jos Buijs, Valeria Napolitano, Giulia Opassi, U. Helena Danielson, Hanna Björkelund, Grzegorz Dubin, João Crispim Encarnação, Hélène Munier-Lehmann, Karl Andersson
المساهمون: Ridgeview Instruments AB [Uppsala, Sueden], Department of Immunology, Genetics and Pathology [Uppsala, Sueden] (IGP), Uppsala University, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Department of Chemistry [Uppsala, Sueden], Biomedical Center = Biomedicinskt centrum [Uppsala, Sueden] (BMC), Uppsala University-Uppsala University, Malopolska Centre of Biotechnology [Krakow] (MCB), Helmholtz-Zentrum München (HZM), Center for Integrated Protein Science (CIPSM), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Helmholtz-Zentrum München (HZM)-Ludwig Maximilian University of Munich [Germany] (LMU München), Chimie et Biocatalyse, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], This project has received funding from the European Union's Framework Programme for Research and Innovation Horizon 2020 (2014–2020) under the Marie Sklodowska‐Curie Grant Agreement No. 675555, Accelerated Early staGe drug discovery (AEGIS)., Microscopic imaging was performed with equipment maintained by the BioVis Platform at Uppsala University. We thank to Dr Arie Geerlof and Dr André Mourão (Institute of Structural Biology, Helmholtz Zentrum München) for providing help on protein expression and purification of the STxB constructs., European Project: 675555,H2020,H2020-MSCA-ITN-2015,AEGIS(2016), Helmholtz Zentrum München = German Research Center for Environmental Health, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Ludwig-Maximilians-Universität München (LMU)-Helmholtz Zentrum München = German Research Center for Environmental Health, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
المصدر: FEBS Lett. 594, 2406-2420 (2020)
FEBS Letters
FEBS Letters, Wiley, 2020, 594 (15), pp.2406-2420. ⟨10.1002/1873-3468.13847⟩
FEBS Letters, 2020, 594 (15), pp.2406-2420. ⟨10.1002/1873-3468.13847⟩مصطلحات موضوعية: media_common.quotation_subject, [SDV]Life Sciences [q-bio], Cell, education, Biophysics, Globotriaosylceramide, cell surface receptor, Biological Transport, Active, Shiga Toxins, Biochemistry, real-time cell-binding assays, 03 medical and health sciences, chemistry.chemical_compound, [SPI]Engineering Sciences [physics], Structural Biology, Cell surface receptor, receptor internalization, Neoplasms, Genetics, medicine, binding kinetics, cancer, Humans, Internalization, Molecular Biology, Binding Kinetics, Cancer, Cell Surface Receptor, Real-time Cell-binding Assays, Receptor Internalization, Shiga Toxin, real-time cell- binding assays, 030304 developmental biology, media_common, 0303 health sciences, Drug Carriers, Chemistry, Trihexosylceramides, 030302 biochemistry & molecular biology, Biochemistry and Molecular Biology, Cell Biology, Shiga toxin, Small molecule, Receptor–ligand kinetics, 3. Good health, Cell biology, ddc, medicine.anatomical_structure, Cancer cell, Biological Assay, K562 Cells, HT29 Cells, Intracellular, Biokemi och molekylärbiologi
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4182f413821e2c51a52d6f7a9bf9a7ffTest
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59243Test -
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المؤلفون: Wolfgang Schliebs, Kamyar Hadian, Bettina Tippler, Michael Sattler, Grzegorz M Popowicz, Kenji Schorpp, Marta Kolonko, Vishal C. Kalel, Ralf Erdmann, Igor V. Tetko, Marcel Kaiser, Leonidas Emmanouilidis, Grzegorz Dubin, Valeria Napolitano, Dominik Lenhart, Pascal Mäser, Roberto Fino, Maciej Dawidowski, Michael Sebastian Ostertag, Oliver Plettenburg
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: 0303 health sciences, biology, Chemistry, fungi, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, 3. Good health, Protein–protein interaction, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Biochemistry, Signaling proteins, parasitic diseases, Drug Discovery, Trypanosoma, Molecular Medicine, Structure–activity relationship, 030304 developmental biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb029db8cead4868f7a46fdbf6527d22Test
https://ruj.uj.edu.pl/xmlui/handle/item/158724Test