A prospective multicenter assessor-blinded randomized controlled study to compare the efficacy of short versus long protocols of electroconvulsive therapy as an augmentation strategy to clozapine in patients with ultra-resistant schizophrenia (SURECT study)

التفاصيل البيبلوغرافية
العنوان: A prospective multicenter assessor-blinded randomized controlled study to compare the efficacy of short versus long protocols of electroconvulsive therapy as an augmentation strategy to clozapine in patients with ultra-resistant schizophrenia (SURECT study)
المؤلفون: Virginie Moulier, Mohamed Wassim Krir, Marine Dalmont, SURECT Group, Olivier Guillin, Maud Rothärmel
المصدر: Trials, Vol 22, Iss 1, Pp 1-15 (2021)
Trials
بيانات النشر: BMC, 2021.
سنة النشر: 2021
مصطلحات موضوعية: medicine.medical_specialty, Medicine (General), medicine.medical_treatment, Medicine (miscellaneous), behavioral disciplines and activities, law.invention, Augmentation strategy, 03 medical and health sciences, Study Protocol, 0302 clinical medicine, Electroconvulsive therapy, R5-920, Randomized controlled trial, law, Internal medicine, mental disorders, D2 Test of Attention, medicine, Humans, Multicenter Studies as Topic, Pharmacology (medical), Prospective Studies, Ultra-resistant schizophrenia, Modified Overt Aggression Scale, Clozapine, Randomized Controlled Trials as Topic, Response rate (survey), business.industry, Neuropsychology, medicine.disease, 030227 psychiatry, Treatment Outcome, Schizophrenia, business, 030217 neurology & neurosurgery, medicine.drug, Antipsychotic Agents
الوصف: Background Although clozapine is the most effective antipsychotic drug for treatment-resistant schizophrenia, it leads to a poor or partial response in 40 to 70% of patients. Augmentation of clozapine with electroconvulsive therapy (ECT) is a highly effective and relatively safe treatment for these clozapine-resistant patients. However, parameters are not yet well specified, such as the optimal number of sessions, their frequency, and the relevance of maintenance ECT. Our objective is to compare the efficacy and tolerance between two protocols of combined ECT and clozapine treatment in patients with ultra-resistant schizophrenia (URS): a 6-month protocol (short protocol with 20 ECT sessions) and a 12-month protocol (long protocol with 40 ECT sessions). Methods Sixty-four patients with schizophrenia with persistent psychotic symptoms despite clozapine treatment will be enrolled in a prospective multicentric assessor-blinded randomized controlled trial. Patients will be randomly assigned to the short or the long protocol. The main outcome is the response rate assessed by the Positive and Negative Symptoms Scale (PANSS) 3 months after the end of the treatment in patients following the long protocol compared to those following the short protocol. The response was defined as a 30% reduction on the PANSS baseline. Clinical assessments (PANSS, BPRS, HAMD-21, YMRS, CGI, GAF, Modified Overt Aggression Scale (MOAS), and Subjective Scale to Investigate Cognition in Schizophrenia (SSTICS)) and plasma clozapine concentration will be performed at baseline and at 2, 4, 6, 9, 12, and 15 months. Neuropsychological measures (MMSE, RL/RI-16, Doors test, D2 Test of Attention, Copy of the Rey-Osterrieth complex figure) will be performed at baseline and at 6 and 15 months. Discussion The aims of this research are to optimize protocols of combined ECT with clozapine in patients with URS and to offer specific recommendations for these patients’ care. Trial registration ClinicalTrials.gov NCT03542903. Registered on May 31, 2018. Id RCB: 2017-A02657-46
اللغة: English
تدمد: 1745-6215
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176925733cfa627bb0e0312057c98db3Test
https://doaj.org/article/25ccb88985a4446385dd01b901c10d54Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....176925733cfa627bb0e0312057c98db3
قاعدة البيانات: OpenAIRE