المؤلفون: Emmanuelle Boll, Francois-Xavier Cantrelle, Olivier Lamotte, Sébastien Aimé, David Wendehenne, Xavier Trivelli

المساهمون: Biologie Structurale Intégrative (ERL 9002 - BSI ), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Agroécologie [Dijon], Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Institut Michel Eugène Chevreul - FR 2638 (IMEC), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), The authors thank the Chevreul Institute (FR 2638) for its help in the development of this work. Chevreul Institute is supported by the « Ministère de l’Enseignement Supérieur et de la Recherche et de l’Innovation», the « CNRS » the « Région Hauts-de-France », the « Métropole Européenne de Lille » and the « Fonds Européen de Développement des Régions ». The Investissements d’Avenir program, project ISITE-BFC (contract ANR-15-IDEX-0003, grant NOISELESS - RA18041.AEC.IS) is alsoacknowledge for its support, ANR-15-IDEX-0003,BFC,ISITE ' BFC(2015), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université d'Artois (UA)-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centrale Lille Institut (CLIL), MILLOT, Dominique

المصدر: Biomolecular NMR Assignments
Biomolecular NMR Assignments, In press, 16 (1), pp.63-66. ⟨10.1007/s12104-021-10060-5⟩

مصطلحات موضوعية: [SDV] Life Sciences [q-bio], calmodulin, calcium, CaM, Structural Biology, [SDV]Life Sciences [q-bio], NMR resonance assignment, tobacco, Biochemistry

الوصف: International audience; Calcium is a ubiquitous second messenger regulating numbers of cellular processes in living organisms. It encodes and transmits information perceived by cells to downstream sensors, including calmodulin (CaM), that initiate cellular responses. In plants, CaM has been involved in the regulation of plant responses to biotic and abiotic environmental cues. Plant CaMs possess a cysteine residue in their first calcium-binding motif EF-hand, which is not conserved in other eucaryotic organisms. In this work, we report the near-complete backbone chemical shift assignment of tobacco CaM2 with calcium. These results will be useful to study the impact of this particular EF-hand domain regarding CaM interaction with partners involved in stress responses.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5010cd448d9ce01e966cbc7d4014b815Test
https://doi.org/10.1007/s12104-021-10060-5Test

المؤلفون: Pauline, Chatelain, Cécile, Blanchard, Jeremy, Astier, Agnès, Klinguer, David, Wendehenne, Sylvain, Jeandroz, Claire, Rosnoblet

المصدر: Scientific reports. 12(1)

مصطلحات موضوعية: Salinity, Gene Expression Regulation, Plant, Stress, Physiological, Gene Expression Profiling, Reference Standards, Streptophyta, Genes, Plant, Real-Time Polymerase Chain Reaction

الوصف: Microalgae have recently emerged as a key research topic, especially as biological models. Among them, the green alga Klebsormidium nitens, thanks to its particular adaptation to environmental stresses, represents an interesting photosynthetic eukaryote for studying the transition stages leading to the colonization of terrestrial life. The tolerance to different stresses is manifested by changes in gene expression, which can be monitored by quantifying the amounts of transcripts by RT-qPCR. The identification of optimal reference genes for experiment normalization was therefore necessary. In this study, using four statistical algorithms followed by the RankAggreg package, we determined the best reference gene pairs suitable for normalizing RT-qPCR data in K. nitens in response to three abiotic stresses: high salinity, PEG-induced dehydration and heat shock. Based on these reference genes, we were able to identify marker genes in response to the three abiotic stresses in K. nitens.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::458f911f6f1de13aa32f014c8a6ee734Test
https://pubmed.ncbi.nlm.nih.gov/36348043Test

المؤلفون: Valérie Nicolas-Francès, Jordan Rossi, Claire Rosnoblet, Carole Pichereaux, Siham Hichami, Jeremy Astier, Agnès Klinguer, David Wendehenne, Angélique Besson-Bard

المصدر: Frontiers in Plant Science, Vol 13 (2022)

مصطلحات موضوعية: Arabidopsis thaliana, nitric oxide, oxidation, H2O2, Plant culture, protein tyrosine phosphatase 1, S-nitrosation, SB1-1110

الوصف: Tyrosine-specific protein tyrosine phosphatases (Tyr-specific PTPases) are key signaling enzymes catalyzing the removal of the phosphate group from phosphorylated tyrosine residues on target proteins. This post-translational modification notably allows the regulation of mitogen-activated protein kinase (MAPK) cascades during defense reactions. Arabidopsis thaliana protein tyrosine phosphatase 1 (AtPTP1), the only Tyr-specific PTPase present in this plant, acts as a repressor of H2O2 production and regulates the activity of MPK3/MPK6 MAPKs by direct dephosphorylation. Here, we report that recombinant histidine (His)-AtPTP1 protein activity is directly inhibited by H2O2 and nitric oxide (NO) exogenous treatments. The effects of NO are exerted by S-nitrosation, i.e., the formation of a covalent bond between NO and a reduced cysteine residue. This post-translational modification targets the catalytic cysteine C265 and could protect the AtPTP1 protein from its irreversible oxidation by H2O2. This mechanism of protection could be a conserved mechanism in plant PTPases.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doajarticles::91125fd904632dd72f32ade059949590Test
https://www.frontiersin.org/articles/10.3389/fpls.2022.807249/fullTest

المؤلفون: Amedea B. Seabra, Neidiquele M. Silveira, Rafael V. Ribeiro, Joana C. Pieretti, Juan B. Barroso, Francisco J. Corpas, José M. Palma, John T. Hancock, Marek Petřivalský, Kapuganti J. Gupta, David Wendehenne, Gary J. Loake, Jorg Durner, Christian Lindermayr, Árpád Molnár, Zsuzsanna Kolbert, Halley C. Oliveira

المساهمون: Ministerio de Economía y Competitividad (España), European Commission, Junta de Andalucía, Fundação Araucária, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Fundações de Amparo à Pesquisa (Brasil)

المصدر: Seabra, A, Silveira, N M, Ribeiro, R V, Pieretti, J C, Barroso, J B, Corpas, F J, Palma, J M, Hancock, J T, Petrivalsky, M, Gupta, K J, Wendehenne, D, Loake, G J, Durner, J, Lindermayr, C, Molnár, Á, Kolbert, Z & Oliveira, H C 2022, ' Nitric oxide-releasing nanomaterials : From basic research to potential biotechnological applications in agriculture ', New Phytologist, vol. 234, no. 4, pp. 1119-1125 . https://doi.org/10.1111/nph.18073Test
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: NOdonor, Nitric oxide (NO), Chitosan, nanotechnology, Physiology, nanoparticle, 01.06. Biológiai tudományok, Agriculture, Plant Science, Plants, Nanomaterial, Nitric Oxide, S-nitrosothiol, Nanoparticle, Animals, Nanotechnology, nanomaterial, NO donor, nitric oxide (NO), Biotechnology

الوصف: Nitric oxide (NO) is a multifunctional gaseous signal that modulates the growth, development and stress tolerance of higher plants. NO donors have been used to boost plant endogenous NO levels and to activate NO-related responses, but this strategy is often hindered by the relative instability of donors. Alternatively, nanoscience offers a new, promising way to enhance NO delivery to plants, as NO-releasing nanomaterials (e.g. S-nitrosothiol-containing chitosan nanoparticles) have many beneficial physicochemical and biochemical properties compared to non-encapsulated NO donors. Nano NO donors are effective in increasing tissue NO levels and enhancing NO effects both in animal and human systems. The authors believe, and would like to emphasize, that new trends and technologies are essential for advancing plant NO research and nanotechnology may represent a breakthrough in traditional agriculture and environmental science. Herein, we aim to draw the attention of the scientific community to the potential of NO-releasing nanomaterials in both basic and applied plant research as alternatives to conventional NO donors, providing a brief overview of the current knowledge and identifying future research directions. We also express our opinion about the challenges for the application of nano NO donors, such as the environmental footprint and stakeholder's acceptance of these materials.
NO research in the Kolbert lab is financed by NRDI Office (grant no. K135303). NO research in the Seabra lab is financed by Fapesp (2018/08194-2, 2020/03646-2) and CNPq (404815/2018-9, 313117/2019-5). NO research in the Oliveira’s lab is financed by Fundacao Araucaria de Apoio ao Desenvolvimento Científico do Parana (18.017.997-6), Fapesp (2019/15095-3) and CNPq (311034/2020-9). NMS and RVR acknowledge the financial support by Fapesp (2012/19167-0, 2015/21546-7, 2017/11279- 7, 2018/08194-2, 2020/03646-2), CNPq (302460/2018–7) and National Program of Post-Doctorate (PNPD, Capes). Research by FJC and JMP is supported by a European Regional Development Fund cofinanced from the Ministry of Economy and Competitiveness (PID 2019-103924 GB-I00) and Junta de Andalucía, Spain.

وصف الملف: text; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c821f06af0badb36ee51841d6ed023Test
https://pubmed.ncbi.nlm.nih.gov/35266146Test

المؤلفون: Pauline Chatelain, Jeremy Astier, David Wendehenne, Claire Rosnoblet, Sylvain Jeandroz

المصدر: Frontiers in Plant Science
Frontiers in Plant Science, Vol 12 (2021)

مصطلحات موضوعية: algae, nitric oxide synthase, Hypothesis and Theory, protein partners, Plant culture, interactome, Plant Science, NO signaling, SB1-1110

الوصف: In animals, NO is synthesized from L-arginine by three isoforms of nitric oxide synthase (NOS) enzyme. NO production and effects have also been reported in plants but the identification of its sources, especially the enzymatic ones, remains one of the critical issues in the field. NOS-like activities have been reported, although there are no homologs of mammalian NOS in the land plant genomes sequenced so far. However, several NOS homologs have been found in algal genomes and transcriptomes. A first study has characterized a functional NOS in the chlorophyte Ostreococcus tauri and the presence of NOS homologs was later confirmed in a dozen algae. These results raise the questions of the significance of the presence of NOS and their molecular diversity in algae. We hypothesize that comparisons among protein structures of the two KnNOS, together with the identification of their interacting partner proteins, might allow a better understanding of the molecular diversification and functioning of NOS in different physiological contexts and, more generally, new insights into NO signaling in photosynthetic organisms. We recently identified two NOS homologs sequences in the genome of the streptophyte Klebsormidium nitens, a model alga in the study of plant adaptation to terrestrial life. The first sequence, named KnNOS1, contains canonical NOS signatures while the second, named KnNOS2, presents a large C-ter extension including a globin domain. In order to identify putative candidates for KnNOSs partner proteins, we draw the protein–protein interaction networks of the three human NOS using the BioGRID database and hypothesized on the biological role of K. nitens orthologs. Some of these conserved partners are known to be involved in mammalian NOSs regulation and functioning. In parallel, our methodological strategy for the identification of partner proteins of KnNOS1 and KnNOS2 by in vitro pull-down assay is presented.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c7fa52860718083e09ecf55df9fb704bTest
http://europepmc.org/articles/PMC8728061Test

المؤلفون: Valérie, Nicolas-Francès, Jordan, Rossi, Claire, Rosnoblet, Carole, Pichereaux, Siham, Hichami, Jeremy, Astier, Agnès, Klinguer, David, Wendehenne, Angélique, Besson-Bard

المصدر: Frontiers in plant science. 13

الوصف: Tyrosine-specific protein tyrosine phosphatases (Tyr-specific PTPases) are key signaling enzymes catalyzing the removal of the phosphate group from phosphorylated tyrosine residues on target proteins. This post-translational modification notably allows the regulation of mitogen-activated protein kinase (MAPK) cascades during defense reactions.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::b40552ea5ff60f74088077628b83c8aaTest
https://pubmed.ncbi.nlm.nih.gov/35222471Test

المؤلفون: Sébastien Aimé, Gabriele Sorci, Johanna Chluba, Jean-Louis Connat, David Wendehenne, Lény Teyssier, Olivier Lamotte

المساهمون: Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Biogéosciences [UMR 6282] (BGS), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Agroécologie [Dijon], Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Work supported by a FEDER grant Phytosafe, Présage 39703 from European Community, and by a grant from the Conseil Régional de Bourgogne (JCE funding)., Laffont, Rémi, Biogéosciences [UMR 6282] [Dijon] (BGS), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement

المصدر: Toxicology Reports
Toxicology Reports, 2020, 7, pp.413-420. ⟨10.1016/j.toxrep.2020.02.013⟩
Toxicology Reports, Vol 7, Iss, Pp 413-420 (2020)
Toxicology Reports, Elsevier, 2020, 7, pp.413-420. ⟨10.1016/j.toxrep.2020.02.013⟩

مصطلحات موضوعية: [SDV.IMM] Life Sciences [q-bio]/Immunology, Health, Toxicology and Mutagenesis, medicine.medical_treatment, XTT, 010501 environmental sciences, A vision for the future of pesticide toxicology, Toxicology, 01 natural sciences, Peripheral blood mononuclear cell, Microbiology, 03 medical and health sciences, Laminarin, chemistry.chemical_compound, 0302 clinical medicine, Immune system, lcsh:RA1190-1270, medicine, Plant defense against herbivory, Pesticides, Cytotoxicity, lcsh:Toxicology. Poisons, 0105 earth and related environmental sciences, Inflammation, Cell metabolic activity, Innate immune system, Danio rerio, ASM, acyl-benzolar-S-methyl, Zebra fish, PBMC, Plant Defense Stimulator, In vitro, 3. Good health, PPP, Plant Protection product, Cytokine, chemistry, PDS, Plant Defense Stimulator, PBMC, peripheral blood mononuclear cells, IL-1β, [SDV.IMM]Life Sciences [q-bio]/Immunology, 030217 neurology & neurosurgery

الوصف: 8 pages; International audience; Among Plant Protection Products (PPP), a new emerging category of pesticides act by stimulating plant defense in order to improve plant resistance against microbial pathogens. Given that these compounds, the so-called Plant Defense Stimulators (PDS) act on innate immunity, we tested, using an in vitro approach on human mononuclear leucocytes (PBMC), the potential toxicity (XTT assay) and inflammatory effects (production of IL-1β) of 4 PPP belonging to different chemical families. We found that two products (LBG-01F34® and Regalis®) did not induce any cytotoxicity or IL-1 β production. The product BION-50 WG®, that contains Acibenzolar-S-methyl (ASM) and silica particles did not present any cytotoxicity but induced a significant increase in the production of the inflammatory cytokine IL-1 β. Finally, Vacciplant® that contains laminarin, was highly cytotoxic and pro-inflammatory. It induced a strong production of IL-1 β when used at a concentration in the culture medium, as low as 0.02 mg/mL. We also tested the potential toxic effect of these 4 PPP on 4 days old zebra fish larvae. After 24 h of exposure, our results indicate that Vacciplant® induced zebra fish larvae mortality at concentration of 20 μg/mL. LBG did not induced significant mortality at concentrations up to 1 mg/mL whereas Regalis was lethal for 0,3 mg/mL concentrations and BION-50 WG began to induce mortality at 2,5 mg/mL. Our results indicate possible effects of PDS on IL-1β production in human cells and fish survival, calling for more studies on the potential noxious side effects of these compounds.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b855f453faee38753756b2cca2227f9Test
http://europepmc.org/articles/PMC7047147Test

المؤلفون: David Wendehenne, Carole Pichereaux, Pascale Winckler, Claire Rosnoblet, Pauline Chatelain, Hervé Bègue, Agnès Klinguer

المساهمون: Agroécologie [Dijon], Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire de parasitologie mycologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Dispositif Inter-régional d'Imagerie Cellulaire [Dijon] (DImaCell), Procédés Alimentaires et Microbiologiques (PAM), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ingénierie et biologie cellulaire et tissulaire (IBCT (ex IFR133)), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Fédération de Recherche Agrobiosciences, Interactions et Biodiversité (FR AIB), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

المصدر: Plant, Cell and Environment
Plant, Cell and Environment, Wiley, 2021, ⟨10.1111/pce.14073⟩

مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Hypersensitive response, Programmed cell death, Proteasome Endopeptidase Complex, Physiology, Protein subunit, ubiquitinome, Plant Science, 01 natural sciences, cryptogein, Cdc48, Fungal Proteins, 03 medical and health sciences, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Valosin Containing Protein, Tobacco, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Plant Immunity, Plant Proteins, biology, Chemistry, Ubiquitin, Ubiquitin homeostasis, Plants, Genetically Modified, Ubiquitinated Proteins, Elicitor, Cell biology, 030104 developmental biology, proteasome, Proteasome, Cell culture, Chaperone (protein), biology.protein, 010606 plant biology & botany

الوصف: The degradation of misfolded proteins is mainly mediated by the ubiquitin-proteasome system (UPS). UPS can be assisted by the protein Cdc48 but the relationship between UPS and Cdc48 in plants has been poorly investigated. Here, we analyzed the regulation of UPS by Cdc48 in tobacco thanks to two independent cell lines overexpressing Cdc48 constitutively and plant leaves overexpressing Cdc48 transiently. In the cell lines, the accumulation of ubiquitinated proteins was affected both quantitatively and qualitatively and the amount of proteasomal subunits was modified, while proteolytic activities were unchanged. Similarly, the over-expression of Cdc48 in planta impacted the accumulation of ubiquitinated proteins. A similar process occurred in leaves overexpressing transiently Rpn3, a proteasome subunit. Cdc48 being involved in plant immunity, its regulation of UPS was also investigated in response to cryptogein, an elicitor of immune responses. In the cell lines stably overexpressing Cdc48 and in leaves transiently overexpressing Cdc48 and/or Rpn3, cryptogein triggered a premature cell death while no increase of the proteasomal activity occurred. Overall, this study highlights a role for Cdc48 in ubiquitin homeostasis and confirms its involvement, as well as that of Rpn3, in the processes underlying the hypersensitive response. This article is protected by copyright. All rights reserved.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eff330f6d7a29c620b5098718fc9587Test
https://pubmed.ncbi.nlm.nih.gov/33908641Test

المؤلفون: Thibault Roudaire, Marie-Claire Héloir, David Wendehenne, Aymeric Zadoroznyj, Laurence Dubrez, Benoit Poinssot

المصدر: Frontiers in Immunology, Vol 11 (2021)

مصطلحات موضوعية: lcsh:Immunologic diseases. Allergy, pathogen-associated molecular patterns, hypersensitive response, NOD-like receptors, pattern recognition receptors, lcsh:RC581-607, damage-associated molecular patterns, Toll-like receptors

الوصف: Both plants and animals are endowed with sophisticated innate immune systems to combat microbial attack. In these multicellular eukaryotes, innate immunity implies the presence of cell surface receptors and intracellular receptors able to detect danger signal referred as damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). Membrane-associated pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), C-type lectin receptors (CLRs), receptor-like kinases (RLKs), and receptor-like proteins (RLPs) are employed by these organisms for sensing different invasion patterns before triggering antimicrobial defenses that can be associated with a form of regulated cell death. Intracellularly, animals nucleotide-binding and oligomerization domain (NOD)-like receptors or plants nucleotide-binding domain (NBD)-containing leucine rich repeats (NLRs) immune receptors likely detect effectors injected into the host cell by the pathogen to hijack the immune signaling cascade. Interestingly, during the co-evolution between the hosts and their invaders, key cross-kingdom cell death-signaling macromolecular NLR-complexes have been selected, such as the inflammasome in mammals and the recently discovered resistosome in plants. In both cases, a regulated cell death located at the site of infection constitutes a very effective mean for blocking the pathogen spread and protecting the whole organism from invasion. This review aims to describe the immune mechanisms in animals and plants, mainly focusing on cell death signaling pathways, in order to highlight recent advances that could be used on one side or the other to identify the missing signaling elements between the perception of the invasion pattern by immune receptors, the induction of defenses or the transmission of danger signals to other cells. Although knowledge of plant immunity is less advanced, these organisms have certain advantages allowing easier identification of signaling events, regulators and executors of cell death, which could then be exploited directly for crop protection purposes or by analogy for medical research.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doajarticles::09f955cdd54602cc85f6a7470edb9042Test
https://www.frontiersin.org/articles/10.3389/fimmu.2020.612452/fullTest

المؤلفون: David Wendehenne

المصدر: Advances in Botanical Research ISBN: 9780128216927

مصطلحات موضوعية: biology, Photosynthesis, Nitrite reductase, biology.organism_classification, Nitric oxide, Nitric oxide synthase, chemistry.chemical_compound, chemistry, Biosynthesis, Algae, Biochemistry, biology.protein, No production, Mode of action

الوصف: The reactive diatomic gas nitric oxide (NO) has been the subject of extensive investigations in plants. These studies revealed that NO is a signaling compound involved in numerous biological processes. Its main physiological functions, as well as its mode of action at the cellular and molecular levels, have been addressed in the 77th Volume of Advances in Botanical Research entitled “Nitric Oxide and Signaling in Plants”. More recently, the discovery and first functional analyses of nitric oxide synthases (NOSs) and NO-forming nitrite reductase in algae allowed a better understanding of NO biosynthesis in photosynthetic organisms. This review updates the NO production mechanisms in algae with a particular focus of NOSs.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5da8de3ab6d140efb1d4dc39b2e4086dTest
https://doi.org/10.1016/bs.abr.2021.01.011Test