المؤلفون: S. Vasoo, E. T. Koh, B. Y. H. Thong

المصدر: APLAR Journal of Rheumatology. 9:157-160

مصطلحات موضوعية: musculoskeletal diseases, medicine.medical_specialty, Systemic lupus erythematosus, business.industry, medicine.disease, Malignancy, Infliximab, Surgery, Etanercept, Rheumatoid arthritis, Heart failure, Internal medicine, medicine, Demyelinating disease, Adalimumab, skin and connective tissue diseases, business, medicine.drug

الوصف: Anti-tumour necrosis factor-α (anti-TNF-α) agents are biologic disease-modifying antirheumatic drugs (DMARDs) used in the treatment of moderate to severe rheumatoid arthritis (RA). We describe the demographic and therapeutic profiles of 22 patients who received anti-TNF-α therapy for RA in two hospitals in Singapore. The majority of patients were female, middle-aged, full-time working adults with limitation in their social or vocational activities. The mean RA disease duration was 101.4 ± 101.6 months (3.4–401.3). All received conventional DMARDs for a mean of almost 7 years before starting anti-TNF-α, with the majority having failed two or more DMARDs. The most commonly used anti-TNF-α therapies were infliximab (90.9%), etanercept (18.2%) and adalimumab (4.5%). Only one patient developed a major infection, while three developed minor infections requiring temporary cessation of anti-TNF-α therapy. There were no cases of malignancy, drug-induced lupus, demyelinating disease or congestive heart failure during an average of 36.9 ± 21.9 months (3.9–63.0) from initiation of therapy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4bcfb59e97e6cd90b58075285d9e17aeTest
https://doi.org/10.1111/j.1479-8077.2006.00191.xTest

المؤلفون: K P, Leong, E Y Y, Chong, K O, Kong, S P, Chan, B Y H, Thong, T Y, Lian, H H, Chng, E T, Koh, C L, Teh, T C, Lau, W G, Law, Y K, Cheng, H, Badsha, L C, Chew, W H, Yong, H S, Howe, Justina, Tan

المصدر: Lupus. 19(1)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Cyclophosphamide, Azathioprine, Severity of Illness Index, Rheumatology, Quality of life, immune system diseases, Internal medicine, Severity of illness, Medicine, Humans, Lupus Erythematosus, Systemic, skin and connective tissue diseases, Physician-Patient Relations, Singapore, Proteinuria, Lupus erythematosus, Systemic lupus erythematosus, business.industry, Middle Aged, medicine.disease, Physical therapy, Linear Models, Quality of Life, Female, medicine.symptom, business, medicine.drug

الوصف: Patients with systemic lupus erythematosus often assess their disease activity differently from their physicians. We studied the factors associated with this discordance. The data provided by 534 systemic lupus erythematosus patients were analyzed. We compared the physician and patient assessments of lupus activity on a visual-assessment scale from the same visit. We collected clinical data and scores from MOS 36-Item Short-Form Health Survey, Systemic Lupus Erythematosus Quality-of-Life Questionnaire, Rheumatology Attitudes Index, Systemic Lupus Erythematosus Disease Activity Index, and revised Systemic Lupus Activity Measure. Patients tended to score their disease activity higher than do their physicians, when these factors were present: poorer general health assessment, presence of thrombocytopenia, hypertension and urinary sediments, and difficulty in carrying groceries. Physicians tended to score the disease activity higher than do the patients in these circumstances proteinuria, hemolysis, use of azathioprine or cyclophosphamide, tiredness, photosensitivity, higher revised Systemic Lupus Activity Measure score, casturia, and patient report of being more easily ill than are other patients. There was only moderate correlation between the discordance in the baseline and the subsequent visits. The physician assessment of disease activity at baseline correlated better with an objective measure of disease activity (revised Systemic Lupus Activity Measure) in the subsequent visit than the patient assessment. In conclusion, discordance in the perception of disease activity between patients and physicians may be amenable to intervention.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe533352626e7f620a49214a4fc44dfTest
https://pubmed.ncbi.nlm.nih.gov/19880553Test