المؤلفون: Flagiello D., Di Natale F., Lancia A., Sebastiani I., Nava F., Milicia A., Erto A.

المساهمون: Flagiello, D., Di Natale, F., Lancia, A., Sebastiani, I., Nava, F., Milicia, A., Erto, A.

المصدر: Chemical Engineering Research and Design. 194:425-438

مصطلحات موضوعية: Wet oxidative scrubbers (WOS), ASPEN PLUS®, General Chemical Engineering, General Chemistry, Chemical reactions kinetic, Flue gas desulfurization (FGD), Chemical absorption column design, Enhancement factor

الوصف: In this work, we propose a methodology to approach the design of chemical absorption columns with fast gas-liquid reactions by an experimental and modelling study, which accounts for thermodynamic (solubility) data, mass-transfer phenomena, and the reaction kinetics contribution. As a reference case, the SO2 absorption in aqueous solution of H2O2 at different concentrations, which oxidizes SO2 to sulfuric acid, is considered. A lab-scale fed-batch bubble column is used to evaluate SO2 solubility dataset in absorbing solutions of distilled water containing different dosages of H2O2. A thermodynamic model is developed and validated in a Thermodynamic Flash block of ASPEN PLUS®, allowing to describe the experimental results with optimum agreement. For kinetic experiments, a lab-scale falling-film absorber is used to investigate both SO2 mass-transfer rates and the fundamental kinetic aspects of an absorption process with chemical reaction. The physical contribution to the mass-transfer rate is evaluated through a set of dedicated experiments, which allowed determining gas-side (kGa) and liquid-side (kLa) coefficients in the falling-film absorber. Subsequently, the Enhancement factor (EL) of the SO2 oxidative absorption is evaluated for the oxidizing reaction (SO2 + H2O2 → H2SO4) under the explored experimental conditions, using the equilibrium dataset and the mass transfer coefficients previously obtained. Finally, EL is correlated to the Hatta number (Ha) with the Danckwerts kinetic model as a pseudo-mth-nth-order non-reversible reaction type and the model kinetic parameters are calculated.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3d507efd7ba45120bc250243cd50dcTest
https://doi.org/10.1016/j.cherd.2023.04.040Test

المؤلفون: Natale Badalamenti, Alessandro Vaglica, Antonella Porrello, Antonella Maggio, Maurizio Bruno, Marianna Lauricella, Antonella D’Anneo

المساهمون: Badalamenti, Natale, Vaglica, Alessandro, Porrello, Antonella, Maggio, Antonella, Bruno, Maurizio, Lauricella, Marianna, D'Anneo, Antonella

المصدر: Natural Product Research. :1-12

مصطلحات موضوعية: antiproliferative activity, roots, coumarins, Organic Chemistry, apiaceae, Plant Science, Ferulago nodosa (L.) Boiss, Biochemistry, NMR, Analytical Chemistry

الوصف: Ferulago nodosa (L.) Boiss. (Apiaceae) is a species occurring in the Balkan-Tyrrhenian area being present in Crete, Greece, Albania, and probably in Macedonia. From the roots of this accession of species, not previously investigated, four coumarins, grandivittin, aegelinol benzoate, felamidin and aegelinol, and two terpenoids, (2E)-3-methyl-4-[(3-methyl-1-oxo-2-buten-1yl)oxy]-2-butenoic acid and pressafonin-A, were isolated and spectroscopically characterized. The last one was never detected in Ferulago species. The evaluation of the anti-tumor effects of F. nodosa coumarins on colon cancer HCT116 cells showed only a modest effect on reduction of tumor cell viability. For aegelinol, the reduction of colon cancer cell viability already appears with 25 µΜ, while using 50 e 100 µM doses of marmesin the residual viability amounted to 70% and 54%, respectively. This effect resulted more evident at higher doses of compounds (at 200 µM from 80% to 0%). The most effective compounds resulted coumarins lacking ester group.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d440059062cdd5a0c22e1a52637287aTest
https://doi.org/10.1080/14786419.2023.2213808Test

المؤلفون: Francesco Natale, Riccardo Molinari, Rosa Franzese, Noemi Mollo, Giovanni Cimmino

المساهمون: Natale, Francesco, Molinari, Riccardo, Franzese, Rosa, Mollo, Noemi, Cimmino, Giovanni

المصدر: Future Pharmacology. 3:392-406

مصطلحات موضوعية: atherosclerosi, low-density lipoprotein, lipid-lowering strategy

الوصف: The goal in cardiovascular prevention is the reduction of morbidity and mortality through the promotion of healthy lifestyles in the general population. The management of modifiable risk factors with pharmacological and non-pharmacological interventions, based on the individual risk is the first strategy suggested by the current guidelines. Several epidemiological studies have clearly shown the direct correlation between high levels of low-density lipoprotein cholesterol (LDL-C) and incidence of cardiovascular diseases. On the other hand, numerous randomized clinical studies have reported a huge benefit in terms of major cardiovascular events achievable by the reduction of LDL-C, thus supporting the notion that “the lower is better”. Among the lipid-lowering strategies, statins are the drugs of choice in cardiovascular prevention, at both primary and secondary level. To achieve the ambitious targets suggested by the current guidelines, other lipid-lowering therapies are currently available in addition to statins, such as ezetimibe the inhibitors of the PCSK9. Pharmacological research has recently led to the development of a new drug, the bempedoic acid, which further enrich the available therapies. This drug also acts on the biosynthesis of cholesterol but at upstream level than statins. From the biochemical point of view, it has the potential to be considered before the statin with consequent titration of statins to achieve the desirable LDL-C target. In the present review, the biochemical and pharmacological characteristics of bempedoic acid are discussed. An overview of the clinical data that support its use in the management of the cardiovascular patient and its allocation in the lipid-lowering scenario will be also provided.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcf54dc1559f6d528f3ec42df0532bfTest
https://doi.org/10.3390/futurepharmacol3020024Test

المؤلفون: Abbey C.E. Rokeby, Bryony V. Natale, David R.C. Natale

المصدر: Placenta. 135:51-61

مصطلحات موضوعية: Reproductive Medicine, Obstetrics and Gynecology, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::86fef65af1e6c777ca538c5a980acf22Test
https://doi.org/10.1016/j.placenta.2023.03.002Test

المؤلفون: Adam J Andrews, Antonio Di Natale, Piero Addis, Federica Piattoni, Vedat Onar, Darío Bernal-Casasola, Veronica Aniceti, Gabriele Carenti, Verónica Gómez-Fernández, Fulvio Garibaldi, Arturo Morales-Muñiz, Fausto Tinti

المساهمون: Andrews, Adam J, Di_Natale, Antonio, Addis, Piero, Piattoni, Federica, Onar, Vedat, Bernal-Casasola, Darío, Aniceti, Veronica, Carenti, Gabriele, Gómez-Fernández, Verónica, Garibaldi, Fulvio, Morales-Muñiz, Arturo, Tinti, Fausto

المصدر: ICES Journal of Marine Science. 80:836-847

مصطلحات موضوعية: Bluefin tuna, fishery-induced evolution, human impact, Ecology, Aquatic Science, Oceanography, Ecology, Evolution, Behavior and Systematics

الوصف: Climate change and size-selective overexploitation can alter fish size and growth, yet our understanding of how and to what extent is limited due to a lack of long-term biological data from wild populations. This precludes our ability to effectively forecast population dynamics and support sustainable fisheries management. Using modern, archived, and archaeological vertebrae dimensions and growth rings of one of the most intensely exploited populations, the eastern Atlantic and Mediterranean bluefin tuna (Thunnus thynnus, BFT), we estimated catch-at-size and early-life growth patterns from the 3rd century bce to the 21st century ce to understand responses to changes in its environment. We provide novel evidence that BFT juvenile growth increased between the 16th–18th, 20th, and 21st centuries, and is correlated with a warming climate and likely a decrease in stock biomass. We found it equally plausible that fisheries-induced evolution has acted to increase juvenile BFT growth, driving earlier maturation as a result of size-selective exploitation. Coincidently, we found limited evidence to suggest a long history of large ( >200 cm FL) BFT capture. Instead, we found that the catch-at-size of archaeological BFT was relatively small in comparison with more intensive, 20th and 21st century tuna trap fisheries which operated further from shore. This complex issue would benefit from studies using fine-scale biochronological analyses of otoliths and adaptation genomics, throughout the last century especially, to determine evolutionary responses to exploitation, and further disentangle the influence of temperature and biomass on fish growth.

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ffd172107251f00f4754c608b4941bTest
https://doi.org/10.1093/icesjms/fsad013Test

المؤلفون: Melissa Gonzalez, Catherine Rama, Aria Nawab, Emily Robertson, Paulina Maria Partridge, Arielle Ashkenazi, Elana Mansoor, Julie Van Weelden, Kristyna Peña, Ruby Natale

المصدر: Infants & Young Children. 36:195-210

مصطلحات موضوعية: Psychiatry and Mental health, Pediatrics, Perinatology and Child Health, Developmental and Educational Psychology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3486715c33121ea3accd021c596f2333Test
https://doi.org/10.1097/iyc.0000000000000243Test

المؤلفون: Michele Balma, Virginia Liberini, Ambra Buschiazzo, Manuela Racca, Alessio Rizzo, Daniele Giovanni Nicolotti, Riccardo Laudicella, Natale Quartuccio, Michelangelo Longo, Giorgia Perlo, Enzo Terreno, Ronan Abgral, Martin William Huellner, Alberto Papaleo, Désirée Deandreis

المصدر: Current Medical Imaging Reviews. 19:817-831

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging

الوصف: Background: Breast cancer is the most common malignancy in women, with high morbidity and mortality. Molecular alterations in breast cancer involve the expression or upregulation of various molecular targets that can be used for diagnostic nuclear medicine imaging and radiopharmaceutical treatment. Theragnostics is based on the binding of radionuclides to molecular targets. These radionuclides can induce a cytotoxic effect on the specific tumor cell (target) or its vicinity, thus allowing a personalized approach to patients with effective treatment and comparably small side effects. Aim: This review aims to describe the most promising molecular targets currently under investigation for theragnostics and precision oncology in breast cancer. Methods: A comprehensive literature search of studies on theragnostics in breast cancer was performed in the PubMed, PMC, Scopus, Google Scholar, Embase, Web of Science, and Cochrane library databases, between 2010 and 2022, using the following terms: breast neoplasm*, breast, breast cancer*, theragnostic*, theranostic*, radioligand therap*, RLT, MET, FLT, FMISO, FES, estradiol, trastuzumab, PD-L1, PSMA, FAPI, FACBC, fluciclovine, FAZA, GRPR, DOTATOC, DOTATATE, CXC4, endoglin, gastrin, mucin1, and syndecan1. Results: Fifty-three studies were included in the systematic review and summarized in six clinical sections: 1) human epidermal growth factor receptor 2 (HER2); 2) somatostatin receptors (SSTRS); 3) prostate-specific membrane antigen radiotracers (PSMA); 4) fibroblast activation protein-α targeted radiotracers; 5) gastrin-releasing peptide receptor-targeted radiotracers; 6) other radiotracers for theragnostics. Conclusion: The theragnostic approach will progressively allow better patient selection, and improve the prediction of response and toxicity, avoiding unnecessary and costly treatment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::51a0fc840534386959675960d5b48695Test
https://doi.org/10.2174/1573405619666230216114748Test

المؤلفون: D. Flagiello, A. Erto, A. Lancia, F. Di Natale

المصدر: Chemical Engineering Research and Design. 194:731-741

مصطلحات موضوعية: General Chemical Engineering, General Chemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::8317d42b70ab6dc21ca563ed165c3fefTest
https://doi.org/10.1016/j.cherd.2023.05.014Test

المؤلفون: Lucio Calandriello, Enrico De Lorenzis, Giuseppe Cicchetti, Rosa D’Abronzo, Amato Infante, Federico Castaldo, Annemilia Del Ciello, Alessandra Farchione, Elisa Gremese, Riccardo Marano, Luigi Natale, Maria Antonietta D’Agostino, Silvia Laura Bosello, Anna Rita Larici

المصدر: Tomography; Volume 9; Issue 3; Pages: 981-994

مصطلحات موضوعية: computed tomography, COVID-19, prognosis, cytokine release syndrome, interleukin-6, Settore MED/16 - REUMATOLOGIA, Radiology, Nuclear Medicine and imaging

الوصف: Elevated inflammatory markers are associated with severe coronavirus disease 2019 (COVID-19), and some patients benefit from Interleukin (IL)-6 pathway inhibitors. Different chest computed tomography (CT) scoring systems have shown a prognostic value in COVID-19, but not specifically in anti-IL-6-treated patients at high risk of respiratory failure. We aimed to explore the relationship between baseline CT findings and inflammatory conditions and to evaluate the prognostic value of chest CT scores and laboratory findings in COVID-19 patients specifically treated with anti-IL-6. Baseline CT lung involvement was assessed in 51 hospitalized COVID-19 patients naive to glucocorticoids and other immunosuppressants using four CT scoring systems. CT data were correlated with systemic inflammation and 30-day prognosis after anti-IL-6 treatment. All the considered CT scores showed a negative correlation with pulmonary function and a positive one with C-reactive protein (CRP), IL-6, IL-8, and Tumor Necrosis Factor α (TNF-α) serum levels. All the performed scores were prognostic factors, but the disease extension assessed by the six-lung-zone CT score (S24) was the only independently associated with intensive care unit (ICU) admission (p = 0.04). In conclusion, CT involvement correlates with laboratory inflammation markers and is an independent prognostic factor in COVID-19 patients representing a further tool to implement prognostic stratification in hospitalized patients.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b001a36e3cee9e5614e6aba51b3f5208Test
https://doi.org/10.3390/tomography9030080Test

المؤلفون: Prashanthan Sanders, Lucas Boersma, Francis Marchlinski, Andrea Natale

المصدر: Circulation. 147:1422-1432

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

الوصف: Background: Pulsed field ablation uses electrical pulses to cause nonthermal irreversible electroporation and induce cardiac cell death. Pulsed field ablation may have effectiveness comparable to traditional catheter ablation while preventing thermally mediated complications. Methods: The PULSED AF pivotal study (Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF) was a prospective, global, multicenter, nonrandomized, paired single-arm study in which patients with paroxysmal (n=150) or persistent (n=150) symptomatic atrial fibrillation (AF) refractory to class I or III antiarrhythmic drugs were treated with pulsed field ablation. All patients were monitored for 1 year using weekly and symptomatic transtelephonic monitoring; 3-, 6-, and 12-month ECGs; and 6- and 12-month 24-hour Holter monitoring. The primary effectiveness end point was freedom from a composite of acute procedural failure, arrhythmia recurrence, or antiarrhythmic escalation through 12 months, excluding a 3-month blanking period to allow recovery from the procedure. The primary safety end point was freedom from a composite of serious procedure- and device-related adverse events. Kaplan-Meier methods were used to evaluate the primary end points. Results: Pulsed field ablation was shown to be effective at 1 year in 66.2% (95% CI, 57.9 to 73.2) of patients with paroxysmal AF and 55.1% (95% CI, 46.7 to 62.7) of patients with persistent AF. The primary safety end point occurred in 1 patient (0.7%; 95% CI, 0.1 to 4.6) in both the paroxysmal and persistent AF cohorts. Conclusions: PULSED AF demonstrated a low rate of primary safety adverse events (0.7%) and provided effectiveness consistent with established ablation technologies using a novel irreversible electroporation energy to treat patients with AF. Registration: URL: https://www.clinicaltrials.govTest ; Unique identifier: NCT04198701.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5e254c648f30869ba601990ca46fb71fTest
https://doi.org/10.1161/circulationaha.123.063988Test