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المؤلفون: Rajdev, Lakshmi, Lee, Ju-Whei, Libutti, Steven K., Benson, Al B., Fisher, George A., Kunz, Pamela L., Hendifar, Andrew E., Catalano, Paul, O’Dwyer, Peter J.
المصدر: Investigational new drugs, vol 40, iss 6
Invest New Drugsمصطلحات موضوعية: Pharmacology, Sirolimus, PNET, Sapanisertib, Clinical Trials and Supportive Activities, Neuroectodermal Tumors, Evaluation of treatments and therapeutic interventions, MTOR Inhibitors, Pharmacology and Pharmaceutical Sciences, Mechanistic Target of Rapamycin Complex 1, Article, Pancreatic Neoplasms, Neuroendocrine Tumors, Oncology, Clinical Research, 6.1 Pharmaceuticals, Primitive, Neuroectodermal Tumors, Primitive, Humans, Pharmacology (medical), Oncology & Carcinogenesis, mTORC1/2 inhibitor, Protein Kinase Inhibitors, Cancer
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16e65b4ab6ada62678650fd0165925dTest
https://escholarship.org/uc/item/40s457s1Test -
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المؤلفون: Ying Zhou, Xiaohong Xu
المصدر: Hematology, Vol 27, Iss 1, Pp 105-112 (2022)
مصطلحات موضوعية: immunomodulators, Antineoplastic Agents, Hematology, Prognosis, pcnsl, btk inhibitors, Central Nervous System Neoplasms, immune checkpoint inhibitors, relapsed and refractory, pi3 k/mtor inhibitors, hemic and lymphatic diseases, Drug Discovery, Animals, Humans, Diseases of the blood and blood-forming organs, Lymphoma, Large B-Cell, Diffuse, Molecular Targeted Therapy, Neoplasm Recurrence, Local, RC633-647.5, Protein Kinase Inhibitors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3026fb0dba76fe3f66d9a0115d32394Test
https://doi.org/10.1080/16078454.2021.2019363Test -
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المؤلفون: Seyed Mohammad Abedi, Samaneh Vaseghi, Nasrin Abbasi Gharibkandi, Alireza Mardanshahi, Sajjad Molavipordanjani
المصدر: Molecular Biology Reports. 48:1-14
مصطلحات موضوعية: Cell Survival, medicine.medical_treatment, Apoptosis, Radiation Tolerance, Phosphatidylinositol 3-Kinases, Cell Line, Tumor, Neoplasms, Autophagy, Genetics, medicine, Humans, Radiosensitivity, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors, Cell growth, Akt/PKB signaling pathway, business.industry, TOR Serine-Threonine Kinases, Cell Cycle, Cancer, MTOR Inhibitors, General Medicine, medicine.disease, Radiation therapy, Cancer research, business, Proto-Oncogene Proteins c-akt, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fdb87979d16875fbb742eee534b74bTest
https://doi.org/10.1007/s11033-021-06607-3Test -
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المؤلفون: Chiara Borsari, Matthias P. Wymann, Martina De Pascale
المصدر: Chemmedchem
مصطلحات موضوعية: mTOR inhibitors, Structural similarity, Allosteric regulation, physicochemical properties, Blood–brain barrier, Biochemistry, binding modes, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, chemical scaffolds, Drug Discovery, medicine, BBB permeability, Humans, General Pharmacology, Toxicology and Pharmaceutics, Protein Kinase Inhibitors, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, 030304 developmental biology, Pharmacology, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Kinase, TOR Serine-Threonine Kinases, Organic Chemistry, Cancer, Minireviews, medicine.disease, Chemical space, 3. Good health, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Molecular Medicine, Minireview
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610b11369182775aec800164fa18275dTest
https://doi.org/10.1002/cmdc.202100332Test -
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المؤلفون: Min Zhang, Han-Yue Qiu, Peng-Fei Wang
المصدر: Expert Opinion on Therapeutic Patents. 31:965-975
مصطلحات موضوعية: Cancer therapy, Antineoplastic Agents, 01 natural sciences, Patents as Topic, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Neoplasms, Drug Discovery, Animals, Humans, Medicine, Protein Kinase Inhibitors, Protein kinase B, PI3K/AKT/mTOR pathway, Pharmacology, Tumor biology, business.industry, Kinase, TOR Serine-Threonine Kinases, General Medicine, Discovery and development of mTOR inhibitors, 0104 chemical sciences, Cancer treatment, Atp competitive, 010404 medicinal & biomolecular chemistry, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f47ac51206b54f8c942d2fffa71b8b6Test
https://doi.org/10.1080/13543776.2021.1940137Test -
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المؤلفون: Beibei Mao, Qi Zhang, Li Ma, Dong-Sheng Zhao, Pan Zhao, Peizheng Yan
المصدر: Molecules (Basel, Switzerland). 27(16)
مصطلحات موضوعية: Inflammation, Sirolimus, TOR Serine-Threonine Kinases, Organic Chemistry, Pharmaceutical Science, MTOR Inhibitors, Mechanistic Target of Rapamycin Complex 1, Analytical Chemistry, Phosphatidylinositol 3-Kinases, Adenosine Triphosphate, Chemistry (miscellaneous), Drug Discovery, Molecular Medicine, Humans, Physical and Theoretical Chemistry, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209164f1b661fd9bdbdaf80c755f74d4Test
https://pubmed.ncbi.nlm.nih.gov/36014530Test -
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المؤلفون: Xin Sun, Binliang Zhang, Leixuan Luo, Yang Yang, Bin He, Qian Zhang, Linxiao Wang, Shan Xu, Pengwu Zheng, Wufu Zhu
المصدر: Bioorganic chemistry. 129
مصطلحات موضوعية: Triazines, TOR Serine-Threonine Kinases, Organic Chemistry, Antineoplastic Agents, MTOR Inhibitors, Biochemistry, Molecular Docking Simulation, Phosphatidylinositol 3-Kinases, Cell Line, Tumor, Neoplasms, Drug Discovery, Humans, Molecular Biology, Proto-Oncogene Proteins c-akt, Protein Kinase Inhibitors, Signal Transduction, Phosphoinositide-3 Kinase Inhibitors, Cell Proliferation
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4791160941230c4cb5e765e20d199895Test
https://pubmed.ncbi.nlm.nih.gov/36587506Test -
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المؤلفون: Patrik Oleksak, Eugenie Nepovimova, Zofia Chrienova, Kamil Musilek, Jiri Patocka, Kamil Kuca
المصدر: European journal of medicinal chemistry. 238
مصطلحات موضوعية: Pharmacology, Sirolimus, Phosphatidylinositol 3-Kinases, TOR Serine-Threonine Kinases, Organic Chemistry, Drug Discovery, Humans, General Medicine, MTOR Inhibitors, Mechanistic Target of Rapamycin Complex 1, Protein Kinase Inhibitors, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5a140d644035590d95b9c2339f9a3fTest
https://pubmed.ncbi.nlm.nih.gov/35688004Test -
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المؤلفون: Tiffany Shaw, Hannah Lee, Robert A. Figlin
المصدر: ONCOLOGY. :306-310
مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Cabozantinib, medicine.medical_treatment, Ipilimumab, chemistry.chemical_compound, Antineoplastic Agents, Immunological, Renal cell carcinoma, Internal medicine, Basic Helix-Loop-Helix Transcription Factors, medicine, Humans, Carcinoma, Renal Cell, Protein Kinase Inhibitors, Randomized Controlled Trials as Topic, Everolimus, business.industry, MTOR Inhibitors, Immunotherapy, medicine.disease, Kidney Neoplasms, respiratory tract diseases, Axitinib, chemistry, Practice Guidelines as Topic, Nivolumab, business, Lenvatinib, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2384827fee72ba75eb3766c87f599354Test
https://doi.org/10.46883/onc.2021.3506.0306Test -
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المؤلفون: Monika Brychtová, Monika Vlachová, Jana Gregorová, Marta Krejčí, Zdeněk Adam, Sabina Ševčíková
المصدر: Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti. 34(6)
مصطلحات موضوعية: Erdheim-Chester Disease, Interleukin 1 Receptor Antagonist Protein, Oncology, Cladribine, Humans, Interferon-alpha, MTOR Inhibitors, Protein Kinase Inhibitors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2ea65ea566d8a7cfab27ddaa202a5fTest
https://pubmed.ncbi.nlm.nih.gov/34911328Test