Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33
| العنوان: | Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33 |
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| المؤلفون: | Valérie Siroux, Walter T. Klimecki, Penelope E. Graves, Fernando D. Martinez, Stefano Guerra |
| المساهمون: | Arizona Respiratory Center, INSERM U823, équipe 12 (Epidémiologie Environnementale appliquée à la Reproduction et la Santé Respiratoire), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Boudier, Anne |
| المصدر: | Journal of Allergy and Clinical Immunology Journal of Allergy and Clinical Immunology, Elsevier, 2005, 116 (3), pp.650-6. ⟨10.1016/j.jaci.2005.05.004⟩ |
| بيانات النشر: | HAL CCSD, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Hypersensitivity, Immediate, Male, Allergy, Candidate gene, Linkage disequilibrium, MESH: Asthma, MESH: Membrane Glycoproteins, Eczema, MESH: Amino Acid Sequence, Immunoglobulin E, Polymerase Chain Reaction, Linkage Disequilibrium, Atopy, 0302 clinical medicine, MESH: Child, Gene cluster, Immunology and Allergy, Hepatitis A Virus Cellular Receptor 1, Child, Chromatography, High Pressure Liquid, Genetics, 0303 health sciences, Membrane Glycoproteins, biology, MESH: Polymorphism, Single Nucleotide, MESH: Genetic Predisposition to Disease, Protein-Tyrosine Kinases, 3. Good health, MESH: Linkage Disequilibrium, Chromosomes, Human, Pair 5, Receptors, Virus, Female, MESH: Hypersensitivity, Immediate, MESH: Chromosomes, Human, Pair 5, Adolescent, Molecular Sequence Data, Immunology, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, MESH: Protein-Tyrosine Kinases, 03 medical and health sciences, MESH: Skin Tests, medicine, Humans, Genetic Predisposition to Disease, Amino Acid Sequence, Allele, MESH: Chromatography, High Pressure Liquid, Skin Tests, 030304 developmental biology, MESH: Adolescent, MESH: Molecular Sequence Data, MESH: Humans, MESH: Polymerase Chain Reaction, medicine.disease, MESH: Receptors, Virus, Asthma, MESH: Male, MESH: Eczema, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, biology.protein, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Female, 030215 immunology |
| الوصف: | International audience; BACKGROUND: The T-cell immunoglobulin domain and mucin domain (TIM) gene family and the gene for IL-2-inducible T-cell kinase (ITK), located in chromosome 5 q 33 and potentially involved in the T-cell proliferation and differentiation, are good candidate genes for allergic diseases. OBJECTIVE: We assessed the role of polymorphisms in the TIM family genes and ITK in atopy, eczema, and asthma. METHODS: Twenty-one polymorphisms in the TIM-ITK gene cluster were genotyped in 564 children enrolled in the Tucson Children's Respiratory Study. Skin prick tests to common allergens were performed at age 6.1 years (n=508), age 10.8 years (n=539), and age 16.6 years (n=424). Asthma and eczema were assessed by questionnaire at these 3 points. Averaged relative risks were estimated. RESULTS: One 15-bp insertion/deletion in exon 4 of TIM 1 was significantly related to atopy and eczema (relative risk associated with carrying at least 1 rare allele=1.24 [1.07--1.45], P=.005; and 1.43 [1.01--2.01], P=.004, respectively). The 3 tested single nucleotide polymorphisms (SNPs) in TIM 3 were significantly related to atopy and eczema. One of them, at position +4259 calculated from the translation start site, predicts a putative change in the amino acid sequence of the protein, and was the most strongly related to atopy (relative risk=1.28 [1.12--1.47]; P=.0003). SNPs in the 5' genomic region in ITK, which show moderate linkage disequilibrium with those in TIM 3, had an independent effect on atopy. None of the polymorphisms studied was related to asthma. CONCLUSION: Our findings support a potential role for SNPs in TIM 1, TIM 3, and ITK, independent of each other, in allergic diseases. |
| اللغة: | English |
| تدمد: | 0091-6749 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c9e628015848b0ea36225bccbf92c8Test https://www.hal.inserm.fr/inserm-00728263Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a4c9e628015848b0ea36225bccbf92c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00916749 |
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