Meta-analysis identifies seven susceptibility loci involved in the atopic march
| العنوان: | Meta-analysis identifies seven susceptibility loci involved in the atopic march |
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| المؤلفون: | Marenholz, Ingo, Esparza-Gordillo, Jorge, Rüschendorf, Franz, Bauerfeind, Anja, Strachan, David P., Spycher, Ben D., Baurecht, Hansjörg, Margaritte-Jeannin, Patricia, Sääf, Annika, Kerkhof, Marjan, Ege, Markus, Baltic, Svetlana, Matheson, Melanie C., Li, Jin, Michel, Sven, Ang, Wei Q., McArdle, Wendy, Arnold, Andreas, Homuth, Georg, Demenais, Florence, Bouzigon, Emmanuelle, Söderhäll, Cilla, Pershagen, Göran, de Jongste, Johan C., Postma, Dirkje S., Braun-Fahrländer, Charlotte, Horak, Elisabeth, Ogorodova, Ludmila M., Puzyrev, Valery P., Bragina, Elena Yu, Hudson, Thomas J., Morin, Charles, Duffy, David L., Marks, Guy B., Robertson, Colin F., Montgomery, Grant W., Musk, Bill, Thompson, Philip J., Martin, Nicholas G., James, Alan, Sleiman, Patrick, Toskala, Elina, Rodriguez, Elke, Fölster-Holst, Regina, Franke, Andre, Lieb, Wolfgang, Gieger, Christian, Heinzmann, Andrea, Rietschel, Ernst, Keil, Thomas, Cichon, Sven, Nöthen, Markus M., Pennell, Craig E., Sly, Peter D., Schmidt, Carsten O., Matanovic, Anja, Schneider, Valentin, Heinig, Matthias, Hübner, Norbert, Holt, Patrick G., Lau, Susanne, Kabesch, Michael, Weidinger, Stefan, Hakonarson, Hakon, Ferreira, Manuel A. R., Laprise, Catherine, Freidin, Maxim B., Genuneit, Jon, Koppelman, Gerard H., Melén, Erik, Dizier, Marie- Hélène, Henderson, A John, Lee, Young Ae |
| المساهمون: | Gastroenterology & Hepatology, Pediatrics, Erasmus MC other, Groningen Research Institute for Asthma and COPD (GRIAC) |
| المصدر: | Marenholz, Ingo; Esparza-Gordillo, Jorge; Rüschendorf, Franz; Bauerfeind, Anja; Strachan, David P; Spycher, Ben D; Baurecht, Hansjörg; Margaritte-Jeannin, Patricia; Sääf, Annika; Kerkhof, Marjan; Ege, Markus; Baltic, Svetlana; Matheson, Melanie C; Li, Jin; Michel, Sven; Ang, Wei Q; McArdle, Wendy; Arnold, Andreas; Homuth, Georg; Demenais, Florence; ... (2015). Meta-analysis identifies seven susceptibility loci involved in the atopic march. Nature communications, 6, p. 8804. Nature Publishing Group 10.1038/ncomms9804 <http://dx.doi.org/10.1038/ncomms9804Test> Nature Communications Nat. Commun. 6:8804 (2015) Nature Communications, 6. Nature Publishing Group Nature Communications 6, 8804 (2015). doi:10.1038/ncomms9804 Nature Communications, 6:8804. Nature Publishing Group |
| بيانات النشر: | Nature Publishing Group, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | HAY-FEVER, Male, Kinesins, Filaggrin Proteins, FOOD ALLERGY, FILAGGRIN MUTATIONS, immune system diseases, Child, RISK, BIRTH COHORT, Nuclear Proteins, Middle Aged, Neoplasm Proteins, DNA-Binding Proteins, Phenotype, Child, Preschool, Disease Progression, Female, ddc:500, Adult, Adolescent, Genotype, Nerve Tissue Proteins, 610 Medicine & health, Polymorphism, Single Nucleotide, Article, Dermatitis, Atopic, Ikaros Transcription Factor, Young Adult, 360 Social problems & social services, Humans, Genetic Predisposition to Disease, JUVENILE MYOCLONIC EPILEPSY, ddc:610, Receptor, Fibroblast Growth Factor, Type 1, CHROMOSOME 11Q13, Calcium-Binding Proteins, CHILDHOOD ASTHMA, Membrane Proteins, Asthma, Repressor Proteins, DERMATITIS, Adaptor Proteins, Vesicular Transport, Amino Acid Transport Systems, Neutral, Logistic Models, Cardiovascular and Metabolic Diseases, GENOMEWIDE ASSOCIATION, Interleukin-4, Carrier Proteins, Genome-Wide Association Study, Transcription Factors |
| الوصف: | Eczema often precedes the development of asthma in a disease course called the ‘atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10−8) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10−9). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema. The development of asthma following eczema is known as the atopic march. Here the authors conduct a GWAS on affected children and identify two novel loci associated with the disease phenotype. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::02df90bb4f4db72f3fdbb14b7ab31019Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....02df90bb4f4db72f3fdbb14b7ab31019 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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