التفاصيل البيبلوغرافية
| العنوان: |
MicroRNA Expression Profiles and Changes with Treatment on Childhood Leukemias |
| المؤلفون: |
Akpinar, F., Polat, A., Balci, Y.I., Akça, Hakan, Şenol, Hande, Tokgun, O. |
| المصدر: |
International Journal of Hematology and Oncology. 30:72-80 |
| بيانات النشر: |
Akademi Doktorlar Yayinevi, 2020. |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
microRNA 218, leukocyte count, preschool child, cytogenetics, Medicine, microRNA 422, microRNA 145, microRNA 222, child, clinical article, microRNA 204, microRNA, adult, childhood leukemia, microRNA 31, Hematology, microRNA 30, unclassified drug, Childhood leukemias, RNA isolation, female, Oncology, Expression (architecture), real time polymerase chain reaction, microRNA 451, young adult, microRNA 331, microRNA 375, microRNA 372, microRNA 21, acute lymphoblastic leukemia, microRNA 23, acute myeloid leukemia, cancer prognosis, Article, reverse transcription polymerase chain reaction, male, follow up, controlled study, human, let 7b, microRNA 520, microRNA 7, business.industry, microRNA 146a, treatment response, microRNA 10, school child, microRNA 128 1, cancer recurrence, adolescent, Cancer research, microRNA 155, business |
| الوصف: |
MicroRNAs are non-protein coding RNAs that have recently been revealed to be effective in cancer biogenesis which effect post-transcriptional gene modification. The incidence of childhood hematologic cancers is increasing. Therefore, this study aimed to investigate the relationship between miRNA expression and its prognosis in childhood leukemias. Twenty-one patients and 5 healthy control subjects were included in the study. Out of 26 subjects, 15 were patients diagnosed with acute lymphoblastic leukemia (ALL), 6 were patients diagnosed with acute myeloblastic leukemia (AML) and 5 were healthy control subjects. Peripheral venous samples were col-lected from the patients before and 1 month after chemotherapy and their miRNA analyses were performed. Decreased expressions of let-7b, miR-31, miR-128-1, miR-218, miR-331, miR-372, miR-375, miR-422, miR-451 and miR-520 were found in patients with AL compared to the healthy control subjects. While the expression of miR-375 decreased in patients with ALL, the expressions of miR-21, miR-222, miR-30, miR-145, miR-146a and miR-155 increased. While the expression of miR-155 increased in patients with AML, the expressions of miR-10, miR-23, miR-218, miR-422 and miR-451 decreased. It was also found that while the expressions of miR-204,miR-7,miR-10, miR-30, miR-155, miR-192, miR-422, miR-451,miR-520, miR-548, miR-375, miR-1, miR-23 and miR-146a increased in patients with leukemia after the treatment, the expressions of let-7b and miR-132 decreased. A positive correlation was found between leukocyte count of patients with leukemia before the treatment and the expressions of miR-128-1 and miR-331 among miRNAs that changed after the treatment. MiRNAs play role in the pathogenesis, treatment response, relapse and prognosis of hematologic malignancies. © 2020, UHOD - Uluslararasi Hematoloji Onkoloji Dergisi. All rights reserved. |
| وصف الملف: |
application/pdf |
| تدمد: |
1306-133X |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847fb57e6e7bf0e4b065cd30629f799aTest
https://doi.org/10.4999/uhod.204076Test |
| حقوق: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....847fb57e6e7bf0e4b065cd30629f799a |
| قاعدة البيانات: |
OpenAIRE |
